Results 61 to 70 of about 125,024 (282)

Competing endogenous RNA (ceRNA) networks in Parkinson's disease: A systematic review

Frontiers in Cellular Neuroscience, 2023
Parkinson's disease (PD) is a distinctive clinical syndrome with several causes and clinical manifestations. Aside from an infectious cause, PD is a rapidly developing neurological disorder with a global rise in frequency. Notably, improved knowledge of molecular pathways and the developing novel diagnostic methods may result in better therapy for PD ...
Mohammad Reza Asadi, Samin Abed, Ghazal Kouchakali, Fateme Fattahi, Hani Sabaie, Marziyeh Sadat Moslehian, Mirmohsen Sharifi-Bonab, Bashdar Mahmud Hussen, Bashdar Mahmud Hussen, Mohammad Taheri, Mohammad Taheri, Soudeh Ghafouri-Fard, Maryam Rezazadeh, Maryam Rezazadeh   +13 more
openaire   +3 more sources

Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons [PDF]

, 2014
Alternative splicing—the production of multiple messenger RNA isoforms from a single gene—is regulated in part by RNA binding proteins. While the RBPs transformer2 alpha (Tra2α) and Tra2β have both been implicated in the regulation of alternative ...
Austin, Caroline A., Best, Andrew, Chabot, Benoit, Cheong Lee, Ka, Cowell, Ian G., Curk, Tomaz, Dalgliesh, Caroline, Danilenko, Marina, Elliott, David J., Hong, Elaine, Hussain, Rafiq, James, Katherine, Keavney, Bernard, Kheirolahi-Kouhestani, Mahsa, Klinck, Roscoe, Santibanez Koref, Mauro, Tyson-Capper, Alison, Venables, Julian P., Wipat, Anil, Xu, Yaobo   +19 more
core   +2 more sources

Comprehensive analysis of competing endogenous RNA networks associated with cholangiocarcinoma

Experimental and Therapeutic Medicine, 2019
Cholangiocarcinoma (CCA) is the second most common type of primary malignancy of the liver. Certain long non-coding RNAs (lncRNAs) have been demonstrated to have key roles in tumor pathogenesis by binding to microRNAs (miRNAs). However, the competing endogenous RNA (ceRNA) network of CCA remains to be fully determined.
Fangting, Xu, Yuchong, Zhao, Gang, Qin, Ye, Huan, Longyan, Li, Wei, Gao   +5 more
openaire   +3 more sources

Genome‐wide identification of a competing endogenous RNA network in cholangiocarcinoma [PDF]

Journal of Cellular Biochemistry, 2019
AbstractCholangiocarcinoma (CCA) is the second widespread liver tumor with relatively poor survival. Increasing evidence in recent studies showed long noncoding RNAs (lncRNAs) exert a crucial impact on the development and progression of CCA based on the mechanism of competing endogenous RNAs (ceRNAs). However, functional roles and regulatory mechanisms
Ganxun Li, Tongtong Liu, Bixiang Zhang, Weixun Chen, Zeyang Ding   +4 more
openaire   +2 more sources

A combination of transcriptional and microRNA regulation improves the stability of the relative concentrations of target genes [PDF]

, 2013
It is well known that, under suitable conditions, microRNAs are able to fine tune the relative concentration of their targets to any desired value. We show that this function is particularly effective when one of the targets is a Transcription Factor (TF)
Baroudi, Mariama El, Bosia, Carla, Caselle, Michele, Ollino, Laura, Riba, Andrea   +4 more
core   +13 more sources

Circular RNA-Associated Competing Endogenous RNA Network and Prognostic Nomogram for Patients With Colorectal Cancer

Frontiers in Oncology, 2019
Background: Genetic characteristics remain underutilized for establishing prognostic models for colorectal cancer (CRC). We explored the underlying regulatory mechanisms of circular RNAs (circRNAs) that act as competing endogenous RNAs (ceRNAs) and ...
Wei Song, Tao Fu
doaj   +1 more source

Direct activation of RNA polymerase III transcription by c-Myc

, 2003
The proto-oncogene product c-Myc has a direct role in both metazoan cell growth and division. RNA polymerase III (pol III) is involved in the generation of transfer RNA and 5S ribosomal RNA, and these molecules must be produced in bulk to meet the need ...
Eisenman, R.N., Gomez-Roman, N., Grandori, C,, White, R.J.   +3 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Identification of a competing endogenous RNA network associated with prognosis of pancreatic adenocarcinoma

Cancer Cell International, 2020
Background Emerging evidence suggests that competing endogenous RNAs plays a crucial role in the development and progress of pancreatic adenocarcinoma (PAAD).
Wanqing Weng, Zhongjing Zhang, Weiguo Huang, Xiangxiang Xu, Boda Wu, Tingbo Ye, Yunfeng Shan, Keqing Shi, Zhuo Lin   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source