Results 51 to 60 of about 125,024 (282)

The characteristics of circRNA as competing endogenous RNA in pathogenesis of acute myeloid leukemia

BMC Cancer, 2021
Background As one of the novel molecules, circRNA has been identified closely involved in the pathogenesis of many diseases. However, the function of circRNA in acute myeloid leukemia (AML) still remains unknown.
Siyuan Zhang
doaj   +1 more source

Target RNAs strike back on MicroRNAs [PDF]

, 2018
MicroRNAs are extensively studied regulatory non-coding small RNAs that silence animal genes throughout most biological processes, typically doing so by binding to partially complementary sequences within target RNAs.
de la Mata, Manuel, Fededa, Juan Pablo, Fuchs Wightman, Federico, Giono, Luciana Eugenia   +3 more
core   +1 more source

eEF1Bγ binds the Che-1 and TP53 gene promoters and their transcripts [PDF]

, 2016
Background: We have previously shown that the eukaryotic elongation factor subunit 1B gamma (eEF1Bγ) interacts with the RNA polymerase II (pol II) alpha-like subunit “C” (POLR2C), alone or complexed, in the pol II enzyme. Moreover, we demonstrated that
Ammassari-teule, Martine, Borreca, Antonella, Corbi, Nicoletta, DELLE MONACHE, Francesca, Di Certo, Maria Grazia, Fanciulli, Maurizio, Gabanella, Francesca, Onori, Annalisa, Passananti, Claudio, Pisani, Cinzia   +9 more
core   +1 more source

Development and analysis of long non-coding RNA-associated competing endogenous RNA network for osteosarcoma metastasis

Hereditas, 2021
Background Osteosarcoma is the primary bone malignant neoplasm that often develops metastasis. Increasing evidences have shown that non-coding RNAs (ncRNAs) relate to the progression of osteosarcoma.
Yucheng Fu, Qi Liu, Qiyuan Bao, Junxiang Wen, Zhuochao Liu, Yuehao Hu, Guoyu He, Cheng Peng, Yiqi Xu, Weibin Zhang   +9 more
doaj   +1 more source

A Potential Autophagy-Related Competing Endogenous RNA Network and Corresponding Diagnostic Efficacy in Schizophrenia

Frontiers in Psychiatry, 2021
Competing endogenous RNA (ceRNA) and autophagy were related to neurological diseases. But the relationship among ceRNA, autophagy and Schizophrenia (SZ) was not clear. In this study, we obtained gene expression profile of SZ patients (GSE38484, GSE54578,
Rongjie Li, Rongjie Li, Qiaoye Wang, Qiaoye Wang, Yufen Qiu, Youshi Meng, Youshi Meng, Lei Wei, Lei Wei, Hao Wang, Hao Wang, Ruikang Mo, Ruikang Mo, Donghua Zou, Donghua Zou, Chunbin Liu   +15 more
doaj   +1 more source

Kinetic modelling of competition and depletion of shared miRNAs by competing endogenous RNAs

, 2018
Non-conding RNAs play a key role in the post-transcriptional regulation of mRNA translation and turnover in eukaryotes. miRNAs, in particular, interact with their target RNAs through protein-mediated, sequence-specific binding, giving rise to extended ...
A Arvey, A Baccarini, A Fatica, A Franks, A Helwak, A Joshi, A Loinger, A Martirosyan, A Martirosyan, A Nadal, A Raveh, A Re, A Riba, A Sanchez, A Sanchez-Mejias, AD Bosson, AK Leung, AM Gurtan, AS Flynt, B Du, B Obermayer, C Bosia, C Bosia, C Bosia, CW Hsu, D Baek, D Kim, DP Bartel, DP Bartel, DP Bartel, DT Gillespie, E Anastasiadou, E Berezikov, E Koller, E Levine, E Levine, FA Karreth, G Tkacik, H Liang, H Teimouri, I Alvarez-Garcia, I Bose, I Legnini, J Breda, J Das, J Fiorentino, J Kwon, J Noorbakhsh, J Tsang, JM Franco-Zorrilla, JM Schmiedel, L López-Maury, L Salmena, L Tsimring, M Chekulaeva, M Figliuzzi, M Figliuzzi, M Gerstein, M Jens, M Klein, M Mauri, M Nitzan, M Osella, M Osella, M Samoilov, MA Gibson, MA Valencia-Sanchez, MS Ebert, MS Ebert, NG Kampen Van, P Flondor, P Mehta, P Sumazin, PB Detwiler, PS Swain, R Denzler, R Denzler, RC Brewster, RC Friedman, RI Gregory, S Djuranovic, S Grigolon, S Guil, S Jonas, S Mukherji, S Pitchiaya, S Sass, S Wang, SD Chandradoss, TB Hansen, TR Cech, U Ala, U Alon, V Siciliano, X Lai, X Wang, X Yuan, Y Liang, Y Shimoni, Y Tay, Y Tay, Y Yuan   +101 more
core   +2 more sources

Transcriptome Analyses of Tumor-Adjacent Somatic Tissues Reveal Genes Co-Expressed with Transposable Elements [PDF]

, 2019
Background: Despite the long-held assumption that transposons are normally only expressed in the germ-line, recent evidence shows that transcripts of transposable element (TE) sequences are frequently found in the somatic cells.
Alberto, Adrian, Chung, Micky, Churchill, Daphnie, Clymer, Cody, Han, Mira V., Jonaid, G. M., Navarro Leija, Omar, Quinton, Sophia, Ross, Austin, Sexton, Corinne E.   +9 more
core   +2 more sources

Comprehensive Analysis of a Long Noncoding RNA-Associated Competing Endogenous RNA Network in Wilms Tumor

Cancer Control, 2020
Long noncoding RNA (lncRNA) plays crucial roles in various biological processes of different cancers, especially acting as a competing endogenous RNA (ceRNA).
Feng Zhang PhD, Liping Zeng MD, Qinming Cai BS, Zihao Xu BS, Ruida Liu BS, Haicheng Zhong BS, Robert Mukiibi PhD, Libin Deng PhD, Xiaoli Tang PhD, Hongbo Xin PhD   +9 more
doaj   +1 more source

Cancer cells exploit an orphan RNA to drive metastatic progression. [PDF]

, 2018
Here we performed a systematic search to identify breast-cancer-specific small noncoding RNAs, which we have collectively termed orphan noncoding RNAs (oncRNAs).
A Fabregat, A Helwak, AA Margolin, AJ Minn, Alicia Y. Zhou, AM Ainsztein, Andrei Goga, AR Kodahl, AR Quinlan, B Kim, B Langmead, Bruce Culbertson, C Roth, CI Wu, CJ David, D Huo, D Ray, DK Simanshu, DN Cooper, EL Nostrand Van, H Goodarzi, H Goodarzi, H Goodarzi, H Goodarzi, Hani Goodarzi, JM Loo, Johnny X. Yu, K Cuk, L Fish, Lisa Fish, LY Chen, M Rehmsmeier, MI Love, MJ Moore, NN Hooten, O Elemento, PD Bos, R Bhargava, R Ren, RK Lin, RO Bak, S Kishore, S Vanharanta, SF Tavazoie, Steven Zhang, T Fiskaa, W Zhou, X Wu, YCT Yang, YS DeRose   +49 more
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Long Noncoding Competing Endogenous RNA Networks in Age-Associated Cardiovascular Diseases [PDF]

International Journal of Molecular Sciences, 2019
Cardiovascular diseases (CVDs) are the most serious health problem in the world, displaying high rates of morbidity and mortality. One of the main risk factors for CVDs is age. Indeed, several mechanisms are at play during aging, determining the functional decline of the cardiovascular system.
Simona Greco, Carlo Gaetano, Fabio Martelli   +2 more
openaire   +2 more sources