Results 51 to 60 of about 5,884,744 (246)

Identification of a competing endogenous RNA network associated with prognosis of pancreatic adenocarcinoma

Cancer Cell International, 2020
Background Emerging evidence suggests that competing endogenous RNAs plays a crucial role in the development and progress of pancreatic adenocarcinoma (PAAD).
Wanqing Weng, Zhongjing Zhang, Weiguo Huang, Xiangxiang Xu, Boda Wu, Tingbo Ye, Yunfeng Shan, Keqing Shi, Zhuo Lin   +8 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Image5_A Novel Competing Endogenous RNA Network Associated With the Pathogenesis of Graves’ Ophthalmopathy.TIFF

, 2021
Background: Growing evidence has recently revealed the characteristics of long noncoding (lncRNA)/circular RNA (circRNA)-microRNA (miRNA)-mRNA networks in numerous human diseases. However, a scientific lncRNA/circRNA-miRNA-mRNA network related to Graves’
Ruili Wei (848963), Zifan Yue (11837303), Pei Mou (814158), Sainan Chen (3204084), Fei Tong (1729285)   +4 more
core   +1 more source

LUCAT1-Mediated Competing Endogenous RNA (ceRNA) Network in Triple-Negative Breast Cancer

Cells
Breast cancer is a heterogeneous disease comprising multiple molecularly distinct subtypes with varied prevalence, prognostics, and treatment strategies.
Deepak Verma, Sumit Siddharth, Ashutosh S. Yende, Qitong Wu, Dipali Sharma   +4 more
doaj   +1 more source

Identification of LINC00665-miR-let-7b-CCNA2 competing endogenous RNA network associated with prognosis of lung adenocarcinoma

Scientific Reports, 2021
Prognosis of patients with lung cancer remains extremely poor; thus, we sought to unearth novel competing endogenous RNA (ceRNA) networks associated with the prognosis of lung adenocarcinoma (LUAD). Aberrant mRNAs were identified from the intersection of
Yusheng Huang, Limei Zhong, Kechao Nie, Lijuan Li, Shaohua Song, Fengbin Liu, Peiwu Li, Donglin Cao, Yufeng Liu   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA [PDF]

, 2011
Recently, a new regulatory circuitry has been identified in which RNAs can crosstalk with each other by competing for shared microRNAs. Such competing endogenous RNAs (ceRNAs) regulate the distribution of miRNA molecules on their targets and thereby ...
CACCHIARELLI, DAVIDE, Cacchiarelli D., Davide Cacchiarelli, SANTINI, Tiziana, STHANDIER, Olga Elena, Cesana M., Olga Sthandier, BOZZONI, Irene, Mauro Chinappi, Marcella Cesana, Tiziana Santini, Ivano Legnini, Bozzoni I., Sthandier O., CHINAPPI, MAURO, LEGNINI, IVANO, Irene Bozzoni, CESANA, MARCELLA, Chinappi M., Santini T., Anna Tramontano, Tramontano A., TRAMONTANO, ANNA, Legnini I., Sthandier, Olga   +24 more
core   +1 more source

Table2_A Novel Competing Endogenous RNA Network Associated With the Pathogenesis of Graves’ Ophthalmopathy.XLSX

, 2021
Background: Growing evidence has recently revealed the characteristics of long noncoding (lncRNA)/circular RNA (circRNA)-microRNA (miRNA)-mRNA networks in numerous human diseases. However, a scientific lncRNA/circRNA-miRNA-mRNA network related to Graves’
Ruili Wei (848963), Zifan Yue (11837303), Pei Mou (814158), Sainan Chen (3204084), Fei Tong (1729285)   +4 more
core   +1 more source

Competing Endogenous RNA (ceRNA) Network Analysis of Autophagy-Related Genes in Hepatocellular Carcinoma

Pharmacogenomics and Personalized Medicine, 2020
Chenyu Yang,1,2,* Yixiu Wang,3 Weijie Xue,4 Yuwei Xie,3 Qian Dong,1,2,* Chengzhan Zhu2,3,* 1Department of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, People’s Republic of China; 2Shandong Provincial Key ...
Yang C, Wang Y, Xue W, Xie Y, Dong Q, Zhu C   +5 more
doaj