Results 41 to 50 of about 125,024 (282)

High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes

Frontiers in Genetics, 2022
Astrocytes are widely distributed in the central nervous system and play an essential role in the function of neuronal cells. Associations between astrocytes and Alzheimer’s disease (AD) have been noted, and recent work has implicated circular RNA ...
Yuxin Deng, Yuxin Deng, Hui Song, Yan Xiao, Yi Zhao, Liangzao Chu, Jiuyang Ding, Xiangchun Shen, Xiaolan Qi, Xiaolan Qi, Xiaolan Qi   +10 more
doaj   +1 more source

Force for ancient and recent life: viral and stem-loop RNA consortia promote life. [PDF]

, 2014
Lytic viruses were thought to kill the most numerous host (i.e., kill the winner). But persisting viruses/defectives can also protect against viruses, especially in a ubiquitous virosphere. In 1991, Yarmolinsky et al.
Villarreal, Luis P
core   +1 more source

Analysis of circular RNA‑associated competing endogenous RNA network in breast cancer

Oncology Letters, 2020
As the most common type of cancer in female patients, the morbidity and mortality rates of breast cancer (BC) are high, and its incidence is gradually increasing worldwide. However, the underlying molecular and genetic mechanisms involved in the etiopathogenesis of BC remain unclear.
Wang, Xuekang, Dong, Yanhan, Wu, Qiong, Lu, Tong, Wang, Yuanyong, Liu, Wenchao, Liu, Chengyu, Xu, Wenhua   +7 more
openaire   +3 more sources

Identification of Circular RNA-Based Immunomodulatory Networks in Colorectal Cancer

Frontiers in Oncology, 2022
BackgroundCircular RNAs (circRNAs) have been recently proposed as hub molecules in various diseases, especially in tumours. We found that circRNAs derived from ribonuclease P RNA component H1 (RPPH1) were highly expressed in colorectal cancer (CRC ...
Zongfeng Feng, Zongfeng Feng, Zongfeng Feng, Leyan Li, Leyan Li, Leyan Li, Yi Tu, Xufeng Shu, Xufeng Shu, Xufeng Shu, Yang Zhang, Yang Zhang, Yang Zhang, Qingwen Zeng, Qingwen Zeng, Qingwen Zeng, Lianghua Luo, Lianghua Luo, Lianghua Luo, Ahao Wu, Ahao Wu, Wenzheng Chen, Wenzheng Chen, Wenzheng Chen, Yi Cao, Yi Cao, Yi Cao, Zhengrong Li, Zhengrong Li, Zhengrong Li   +29 more
doaj   +1 more source

Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. [PDF]

, 2018
Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined.
Bibikova, Elena, Danilova, Nadia, Lin, Shuo, Sakamoto, Kathleen M, Wilkes, Mark, Youn, Min-Young   +5 more
core   +2 more sources

Interaction and cross-talk between non-coding RNAs. [PDF]

, 2017
Non-coding RNA (ncRNA) has been shown to regulate diverse cellular processes and functions through controlling gene expression. Long non-coding RNAs (lncRNAs) act as a competing endogenous RNAs (ceRNAs) where microRNAs (miRNAs) and lncRNAs regulate each ...
Dahiya, Rajvir, Imai-Sumida, Mitsuho, Tanaka, Yuichiro, Yamamura, Soichiro   +3 more
core   +2 more sources

Competing endogenous RNA regulatory network in papillary thyroid carcinoma

Molecular Medicine Reports, 2018
The present study aimed to screen all types of RNAs involved in the development of papillary thyroid carcinoma (PTC). RNA‑sequencing data of PTC and normal samples were used for screening differentially expressed (DE) microRNAs (DE‑miRNAs), long non‑coding RNAs (DE‑lncRNAs) and genes (DEGs).
Chen, Shouhua, Fan, Xiaobin, Gu, He, Zhang, Lili, Zhao, Wenhua   +4 more
openaire   +3 more sources

Decoding competing endogenous RNA networks for cancer biomarker discovery

Briefings in Bioinformatics, 2019
Abstract Crosstalk between competing endogenous RNAs (ceRNAs) is mediated by shared microRNAs (miRNAs) and plays important roles both in normal physiology and tumorigenesis; thus, it is attractive for systems-level decoding of gene regulation.
Xin, Qi, Yuxin, Lin, Jiajia, Chen, Bairong, Shen   +3 more
openaire   +2 more sources

PVT1: a rising star among oncogenic long non-coding RNAs [PDF]

, 2015
It is becoming increasingly clear that short and long noncoding RNAs critically participate in the regulation of cell growth, differentiation, and (mis)function.
Colombo, Teresa, Farina, Lorenzo, Macino, Giuseppe, Paci, Paola   +3 more
core   +4 more sources

Virus-induced gene complementation reveals a transcription factor network in modulation of tomato fruit ripening [PDF]

, 2012
Plant virus technology, in particular virus-induced gene silencing, is a widely used reverse- and forward-genetics tool in plant functional genomics. However the potential of virus technology to express genes to induce phenotypes or to complement mutants
Fan, Zaifeng, Gallusci, Philippe, Giovannoni, James J., Hong, Yiguo, Jackson, Stephen D., Jin, Mingfei, Lai, Tongfei, Liu, Yule, Qin, Cheng, Rolin, Dominique, Shi, Nongnong, Wang, Huizhong, Wu, Zirong, Zhang, Hang, Zhong, Silin, Zhou, Tao   +15 more
core   +3 more sources