Results 41 to 50 of about 81,616 (246)

Competing endogenous RNA (ceRNA) networks in Parkinson's disease: A systematic review

Frontiers in Cellular Neuroscience, 2023
Parkinson's disease (PD) is a distinctive clinical syndrome with several causes and clinical manifestations. Aside from an infectious cause, PD is a rapidly developing neurological disorder with a global rise in frequency. Notably, improved knowledge of molecular pathways and the developing novel diagnostic methods may result in better therapy for PD ...
Mohammad Reza Asadi, Samin Abed, Ghazal Kouchakali, Fateme Fattahi, Hani Sabaie, Marziyeh Sadat Moslehian, Mirmohsen Sharifi-Bonab, Bashdar Mahmud Hussen, Bashdar Mahmud Hussen, Mohammad Taheri, Mohammad Taheri, Soudeh Ghafouri-Fard, Maryam Rezazadeh, Maryam Rezazadeh   +13 more
openaire   +3 more sources

Decoding competing endogenous RNA networks for cancer biomarker discovery

Briefings in Bioinformatics, 2019
Abstract Crosstalk between competing endogenous RNAs (ceRNAs) is mediated by shared microRNAs (miRNAs) and plays important roles both in normal physiology and tumorigenesis; thus, it is attractive for systems-level decoding of gene regulation.
Xin Qi, Yuxin Lin, Jiajia Chen, Bairong Shen   +3 more
openaire   +2 more sources

Comprehensive analysis of competing endogenous RNA networks associated with cholangiocarcinoma

Experimental and Therapeutic Medicine, 2019
Cholangiocarcinoma (CCA) is the second most common type of primary malignancy of the liver. Certain long non-coding RNAs (lncRNAs) have been demonstrated to have key roles in tumor pathogenesis by binding to microRNAs (miRNAs). However, the competing endogenous RNA (ceRNA) network of CCA remains to be fully determined.
Fangting, Xu, Yuchong, Zhao, Gang, Qin, Ye, Huan, Longyan, Li, Wei, Gao   +5 more
openaire   +3 more sources

Development and analysis of long non-coding RNA-associated competing endogenous RNA network for osteosarcoma metastasis

Hereditas, 2021
Background Osteosarcoma is the primary bone malignant neoplasm that often develops metastasis. Increasing evidences have shown that non-coding RNAs (ncRNAs) relate to the progression of osteosarcoma.
Yucheng Fu, Qi Liu, Qiyuan Bao, Junxiang Wen, Zhuochao Liu, Yuehao Hu, Guoyu He, Cheng Peng, Yiqi Xu, Weibin Zhang   +9 more
doaj   +1 more source

Competing endogenous RNA regulatory network in papillary thyroid carcinoma

Molecular Medicine Reports, 2018
The present study aimed to screen all types of RNAs involved in the development of papillary thyroid carcinoma (PTC). RNA‑sequencing data of PTC and normal samples were used for screening differentially expressed (DE) microRNAs (DE‑miRNAs), long non‑coding RNAs (DE‑lncRNAs) and genes (DEGs).
Chen, Shouhua, Fan, Xiaobin, Gu, He, Zhang, Lili, Zhao, Wenhua   +4 more
openaire   +3 more sources

A Potential Autophagy-Related Competing Endogenous RNA Network and Corresponding Diagnostic Efficacy in Schizophrenia

Frontiers in Psychiatry, 2021
Competing endogenous RNA (ceRNA) and autophagy were related to neurological diseases. But the relationship among ceRNA, autophagy and Schizophrenia (SZ) was not clear. In this study, we obtained gene expression profile of SZ patients (GSE38484, GSE54578,
Rongjie Li, Rongjie Li, Qiaoye Wang, Qiaoye Wang, Yufen Qiu, Youshi Meng, Youshi Meng, Lei Wei, Lei Wei, Hao Wang, Hao Wang, Ruikang Mo, Ruikang Mo, Donghua Zou, Donghua Zou, Chunbin Liu   +15 more
doaj   +1 more source

Molecular Network-Based Identification of Competing Endogenous RNAs in Thyroid Carcinoma [PDF]

Genes, 2018
RNAs may act as competing endogenous RNAs (ceRNAs), a critical mechanism in determining gene expression regulations in many cancers. However, the roles of ceRNAs in thyroid carcinoma remains elusive. In this study, we have developed a novel pipeline called Molecular Network-based Identification of ceRNA (MNIceRNA) to identify ceRNAs in thyroid ...
Minjia Lu, Xingyu Xu, Baohang Xi, Qi Dai, Chenli Li, Li Su, Xiaonan Zhou, Min Tang, Yuhua Yao, Jialiang Yang   +9 more
openaire   +2 more sources

Interferon-alpha competing endogenous RNA network antagonizes microRNA-1270 [PDF]

Cellular and Molecular Life Sciences, 2015
A new form of circuitry for gene regulation has been identified in which RNAs can crosstalk by competing for shared microRNAs (miRNAs). Such competing endogenous RNAs (ceRNAs) form a network via shared miRNA response elements (MREs) to antagonize miRNA function.
Kimura, Tominori, Jiang, Shiwen, Yoshida, Noriyuki, Sakamoto, Ryou, Nishizawa, Mikio   +4 more
openaire   +2 more sources

Circular RNA-Associated Competing Endogenous RNA Network and Prognostic Nomogram for Patients With Colorectal Cancer

Frontiers in Oncology, 2019
Background: Genetic characteristics remain underutilized for establishing prognostic models for colorectal cancer (CRC). We explored the underlying regulatory mechanisms of circular RNAs (circRNAs) that act as competing endogenous RNAs (ceRNAs) and ...
Wei Song, Tao Fu
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source