Results 31 to 40 of about 81,616 (246)

Modelling Competing Endogenous RNA Networks

PLoS ONE, 2013
28 pages, 9 pdf ...
Carla Bosia, Andrea Pagnani, Riccardo Zecchina   +2 more
openaire   +5 more sources

LncRNA H19 regulates PI3K–Akt signal pathway by functioning as a ceRNA and predicts poor prognosis in colorectal cancer: integrative analysis of dysregulated ncRNA-associated ceRNA network

Cancer Cell International, 2019
Background It is becoming increasingly clear that cancers can rarely be ascribed to just one or a few genomic variations. Genes generally do not function alone, but in groups that function as “networks”. This study aimed to develop a competing endogenous
Min-Er Zhong, Yanyu Chen, Guannan Zhang, Lai Xu, Wei Ge, Bin Wu   +5 more
doaj   +1 more source

Circular RNAs and competing endogenous RNA (ceRNA) networks

Translational Cancer Research, 2018
In recent years, advances in bioinformatics approaches have allowed a systematic characterization of circular RNAs (circRNAs) across a variety of cell types. Demonstration of cell type specificity, regulated expression, and conservation between species all suggest that circRNAs have functional importance.
Apratim, Mitra, Karl, Pfeifer, Ki-Sun, Park   +2 more
openaire   +2 more sources

Competing endogenous RNA networks and gastric cancer

World Journal of Gastroenterology, 2015
Recent studies have showed that RNAs regulate each other with microRNA (miRNA) response elements (MREs) and this mechanism is known as "competing endogenous RNA (ceRNA)" hypothesis. Long non-coding RNAs (lncRNAs) are supposed to play important roles in cancer.
Lei-Lei, Guo, Chun-Hua, Song, Peng, Wang, Li-Ping, Dai, Jian-Ying, Zhang, Kai-Juan, Wang   +5 more
openaire   +2 more sources

The expression profiles of circular RNAs and competing endogenous RNA networks in intrahepatic cholangiocarcinoma

Frontiers in Cell and Developmental Biology, 2022
Introduction: Intrahepatic cholangiocarcinoma (iCCA) is a heterogeneous entity with diverse etiologies, morphologies, and clinical outcomes, but our knowledge of its epidemiology and carcinogenesis is very limited.Materials and methods: The expression patterns of circRNAs were explored in iCCA tissues and corresponding adjacent normal ones, denoted by (
Zi Liang, Zi Liang, Liyan Liu, Xinyi Guo, Xia Wu, Yun-Li Yu, Ziyang Yu, Xiaolong Hu, Xing Zhang, Ji Wang   +9 more
openaire   +3 more sources

Genome‐wide identification of a competing endogenous RNA network in cholangiocarcinoma [PDF]

Journal of Cellular Biochemistry, 2019
AbstractCholangiocarcinoma (CCA) is the second widespread liver tumor with relatively poor survival. Increasing evidence in recent studies showed long noncoding RNAs (lncRNAs) exert a crucial impact on the development and progression of CCA based on the mechanism of competing endogenous RNAs (ceRNAs). However, functional roles and regulatory mechanisms
Ganxun Li, Tongtong Liu, Bixiang Zhang, Weixun Chen, Zeyang Ding   +4 more
openaire   +2 more sources

High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes

Frontiers in Genetics, 2022
Astrocytes are widely distributed in the central nervous system and play an essential role in the function of neuronal cells. Associations between astrocytes and Alzheimer’s disease (AD) have been noted, and recent work has implicated circular RNA ...
Yuxin Deng, Yuxin Deng, Hui Song, Yan Xiao, Yi Zhao, Liangzao Chu, Jiuyang Ding, Xiangchun Shen, Xiaolan Qi, Xiaolan Qi, Xiaolan Qi   +10 more
doaj   +1 more source

Identification of Circular RNA-Based Immunomodulatory Networks in Colorectal Cancer

Frontiers in Oncology, 2022
BackgroundCircular RNAs (circRNAs) have been recently proposed as hub molecules in various diseases, especially in tumours. We found that circRNAs derived from ribonuclease P RNA component H1 (RPPH1) were highly expressed in colorectal cancer (CRC ...
Zongfeng Feng, Zongfeng Feng, Zongfeng Feng, Leyan Li, Leyan Li, Leyan Li, Yi Tu, Xufeng Shu, Xufeng Shu, Xufeng Shu, Yang Zhang, Yang Zhang, Yang Zhang, Qingwen Zeng, Qingwen Zeng, Qingwen Zeng, Lianghua Luo, Lianghua Luo, Lianghua Luo, Ahao Wu, Ahao Wu, Wenzheng Chen, Wenzheng Chen, Wenzheng Chen, Yi Cao, Yi Cao, Yi Cao, Zhengrong Li, Zhengrong Li, Zhengrong Li   +29 more
doaj   +1 more source

Competing Endogenous RNA Network Analysis Reveals Pivotal ceRNAs in Adrenocortical Carcinoma

Frontiers in Endocrinology, 2019
Objective: To construct ceRNA network and identify pivotal competing endogenous RNAs (ceRNAs) in adrenocortical carcinoma (ACC) using ceRNA network analysis.Methods: The RNA sequencing expression data of 77 ACCs in TCGA were obtained from GEPIA.
Weiwei Liang, Fangfang Sun
doaj   +1 more source

The characteristics of circRNA as competing endogenous RNA in pathogenesis of acute myeloid leukemia

BMC Cancer, 2021
Background As one of the novel molecules, circRNA has been identified closely involved in the pathogenesis of many diseases. However, the function of circRNA in acute myeloid leukemia (AML) still remains unknown.
Siyuan Zhang
doaj   +1 more source