Construction of competing endogenous RNA interaction network as prognostic markers in metastatic melanoma [PDF]
PeerJ, 2021 Malignant melanoma (MM) is a malignant tumor originating from melanocytes, with high aggressiveness, high metastasis and extremely poor prognosis.
Zan He +4 more
doaj +2 more sources
The role of competing endogenous RNA network in the development of hepatocellular carcinoma: potential therapeutic targets. [PDF]
Front Cell Dev BiolTang Z +5 more
europepmc +2 more sources
Modelling Competing Endogenous RNA Networks
PLoS ONE, 2013 28 pages, 9 pdf ...
Bosia C +3 more
openaire +6 more sources
The miR-223 host non-coding transcript linc-223 induces IRF4 expression in acute myeloid leukemia by acting as a competing endogenous RNA [PDF]
, 2016 Alterations in genetic programs required for terminal myeloid differentiation and aberrant proliferation characterize acute myeloid leukemia (AML) cells.
Bozzoni, Irene +8 more
core +2 more sources
Cancer Cell International, 2019 Background It is becoming increasingly clear that cancers can rarely be ascribed to just one or a few genomic variations. Genes generally do not function alone, but in groups that function as “networks”. This study aimed to develop a competing endogenous
Min-Er Zhong +5 more
doaj +1 more source
The long noncoding RNA linc-NeD125 controls the expression of medulloblastoma driver genes by microRNA sponge activity [PDF]
, 2017 Long noncoding RNAs (lncRNAs) are major regulators of physiological and disease-related gene expression, particularly in the central nervous system. Dysregulated lncRNA expression has been documented in several human cancers, and their tissue-specificity
Alfano, Vincenzo +14 more
core +1 more source
Circular RNAs and competing endogenous RNA (ceRNA) networks
Translational Cancer Research, 2018 In recent years, advances in bioinformatics approaches have allowed a systematic characterization of circular RNAs (circRNAs) across a variety of cell types. Demonstration of cell type specificity, regulated expression, and conservation between species all suggest that circRNAs have functional importance.
Apratim, Mitra +2 more
openaire +2 more sources
Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion [PDF]
, 2017 Thousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions.
Chen, Xiao-wan +9 more
core +2 more sources
Competing endogenous RNA networks and gastric cancer
World Journal of Gastroenterology, 2015 Recent studies have showed that RNAs regulate each other with microRNA (miRNA) response elements (MREs) and this mechanism is known as "competing endogenous RNA (ceRNA)" hypothesis. Long non-coding RNAs (lncRNAs) are supposed to play important roles in cancer.
Lei-Lei, Guo +5 more
openaire +2 more sources
Extracellular vesicles produced in B cells deliver tumor suppressor miR-335 to breast cancer cells disrupting oncogenic programming in vitro and in vivo. [PDF]
, 2018 The successful implementation of miRNA (miR) therapies in humans will ultimately rely on the use of vehicles with improved cellular delivery capability. Here we tested a new system that leverages extracellular vesicles (EVs) laden with a tumor suppressor
Almanza, Gonzalo +5 more
core +2 more sources