Results 71 to 80 of about 5,884,744 (246)

Table5_A Novel Competing Endogenous RNA Network Associated With the Pathogenesis of Graves’ Ophthalmopathy.XLSX

, 2021
Background: Growing evidence has recently revealed the characteristics of long noncoding (lncRNA)/circular RNA (circRNA)-microRNA (miRNA)-mRNA networks in numerous human diseases. However, a scientific lncRNA/circRNA-miRNA-mRNA network related to Graves’
Ruili Wei (848963), Zifan Yue (11837303), Pei Mou (814158), Sainan Chen (3204084), Fei Tong (1729285)   +4 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Image3_A Novel Competing Endogenous RNA Network Associated With the Pathogenesis of Graves’ Ophthalmopathy.TIF

, 2021
Background: Growing evidence has recently revealed the characteristics of long noncoding (lncRNA)/circular RNA (circRNA)-microRNA (miRNA)-mRNA networks in numerous human diseases. However, a scientific lncRNA/circRNA-miRNA-mRNA network related to Graves’
Ruili Wei (848963), Zifan Yue (11837303), Pei Mou (814158), Sainan Chen (3204084), Fei Tong (1729285)   +4 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Table8_A Novel Competing Endogenous RNA Network Associated With the Pathogenesis of Graves’ Ophthalmopathy.XLSX

, 2021
Background: Growing evidence has recently revealed the characteristics of long noncoding (lncRNA)/circular RNA (circRNA)-microRNA (miRNA)-mRNA networks in numerous human diseases. However, a scientific lncRNA/circRNA-miRNA-mRNA network related to Graves’
Ruili Wei (848963), Zifan Yue (11837303), Pei Mou (814158), Sainan Chen (3204084), Fei Tong (1729285)   +4 more
core   +1 more source

Dynamical network analysis reveals key microRNAs in progressive stages of lung cancer.

PLoS Computational Biology, 2020
Non-coding RNAs are fundamental to the competing endogenous RNA (CeRNA) hypothesis in oncology. Previous work focused on static CeRNA networks. We construct and analyze CeRNA networks for four sequential stages of lung adenocarcinoma (LUAD) based on ...
Chao Kong, Yu-Xiang Yao, Zhi-Tong Bing, Bing-Hui Guo, Liang Huang, Zi-Gang Huang, Ying-Cheng Lai   +6 more
doaj   +1 more source

Coding and non-coding gene regulatory networks underlie the immune response in liver cirrhosis. [PDF]

PLoS ONE, 2017
Liver cirrhosis is recognized as being the consequence of immune-mediated hepatocyte damage and repair processes. However, the regulation of these immune responses underlying liver cirrhosis has not been elucidated.
Bo Gao, Xueming Zhang, Yongming Huang, Zhengpeng Yang, Yuguo Zhang, Weihui Zhang, Zu-Hua Gao, Dongbo Xue   +7 more
doaj   +1 more source

Transient Cytoskeletal Anisotropy Encodes Short‐Term Mechanical Memory in Glioblastoma Cells

Advanced Materials, EarlyView.
The same mechanical deformation can produce distinct cytoskeletal states depending on loading history. Experiments and constitutive modeling reveal that transient actin–vimentin anisotropy stores mechanical information and governs short‐term mechanical memory in glioblastoma cells.
Clara Gomez‐Cruz, Matthieu Gelin, Lucas Pradeau‐Phélut, Arrate Muñoz‐Barrutia, Sandrine Etienne‐Manneville, Daniel Garcia‐Gonzalez   +5 more
wiley   +1 more source

Table3_A Novel Competing Endogenous RNA Network Associated With the Pathogenesis of Graves’ Ophthalmopathy.XLSX

, 2021
Background: Growing evidence has recently revealed the characteristics of long noncoding (lncRNA)/circular RNA (circRNA)-microRNA (miRNA)-mRNA networks in numerous human diseases. However, a scientific lncRNA/circRNA-miRNA-mRNA network related to Graves’
Ruili Wei (848963), Zifan Yue (11837303), Pei Mou (814158), Sainan Chen (3204084), Fei Tong (1729285)   +4 more
core   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source