Results 11 to 20 of about 638,552 (336)
Complement activation in placental malaria [PDF]
Frontiers in Microbiology, 2015 Sixty percent of all pregnancies worldwide occur in malaria endemic regions. Pregnant women are at greater risk of malaria infection than their non-pregnant counterparts and are more likely to develop severe disease.
Chloe Ross McDonald +2 more
doaj +5 more sources
Pentraxins in Complement Activation and Regulation [PDF]
Frontiers in Immunology, 2018 The complement is the first line of immune defense system involved in elimination of invading pathogens and dying host cells. Its activation is mainly triggered by immune complexes or pattern recognition molecules (PRMs) upon recognition against non-self
Ying Jie Ma, Peter Garred
doaj +5 more sources
Pathways of complement activation in glomerulonephritis [PDF]
Kidney International, 1972 Pathways of complement activation in glomerulonephritis.Systemic lupus erythematosus and hypocomplementemic glomerulonephritis are characterized by depressed CH50 and C3 levels, but the complement profiles in these two diseases show marked differences.Measurement of hemolytic activity of C1, C4 and C2 and of protein concentrations by radial ...
Nancy H. Holland +2 more
openalex +3 more sources
Complement Activation and Thrombotic Microangiopathies [PDF]
Clinical Journal of the American Society of Nephrology, 2019 Background and objectivesAtypical hemolytic uremic syndrome is a form of thrombotic microangiopathy caused by dysregulation of the alternative complement pathway. There is evidence showing complement activation in other thrombotic microangiopathies. The aim of this study was to evaluate complement activation in different thrombotic microangiopathies ...
Marta Palomo +36 more
openaire +9 more sources
A Review of Complement Activation in SLE [PDF]
Current Rheumatology Reports, 2021 Abstract Purpose of Review Complement activation is a key event in the pathogenesis of tissue inflammation and injury in systemic lupus erythematosus (SLE). This review is aimed at comparing the usefulness of measurement of complement proteins in serum/plasma (C3, C4) to complement activation (split) products in plasma ...
Arthur Weinstein +2 more
openaire +4 more sources
Pulmonary complement depositions in autopsy of critically ill patients have no relation with ARDS
Intensive Care Medicine Experimental, 2019 Background The complement system has frequently been suggested to play a role in the pathophysiology of acute respiratory distress syndrome (ARDS).
Friso M. de Beer +6 more
doaj +1 more source
Platelets, 2022 Platelet transfusion refractoriness is a serious clinical concern that complicates the management of thrombocytopenic patients. Previous studies have suggested a potential role for both complement and platelet activation based on in vitro analyses of ...
Alexander Åkesson +7 more
doaj +1 more source
Engineering novel complement activity into a pulmonary surfactant protein [PDF]
, 2010 Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Anthony H. Keeble +38 more
core +2 more sources
COMPLEMENT-MEDIATED ADIPOCYTE LYSIS BY NEPHRITIC FACTOR SERA [PDF]
, 1993 Recent data indicate a previously unsuspected link between the complement system and adipocyte biology. Murine adipocytes produce key components of the alternative pathway of complement and are able to activate this pathway.
Lachmann, PJ +4 more
core +1 more source
Complement activation in IgA nephropathy [PDF]
Seminars in Immunopathology, 2021 AbstractIgA nephropathy pathogenesis is incompletely understood, and this limits the development of disease-specific biomarkers and effective therapies. Evidence of complement activity in IgA nephropathy is well established. However, a growing body of research indicates complement activity is an important contributor to IgA nephropathy pathology.
Nicholas R. Medjeral-Thomas +2 more
openaire +4 more sources