Results 11 to 20 of about 4,590,839 (398)
Polyphosphates and Complement Activation [PDF]
Frontiers in Medicine, 2019 To sustain life in environments that are fraught with risks of life-threatening injury, organisms have developed innate protective strategies such that the response to wounds is rapid and localized, with the simultaneous recruitment of molecular ...
Edward M. Conway
doaj +3 more sources
Complement activation in IgA nephropathy [PDF]
Seminars in Immunopathology, 2021 IgA nephropathy pathogenesis is incompletely understood, and this limits the development of disease-specific biomarkers and effective therapies. Evidence of complement activity in IgA nephropathy is well established.
N. Medjeral-Thomas +2 more
semanticscholar +5 more sources
Complement Activation and Thrombotic Microangiopathies. [PDF]
Clinical Journal of the American Society of Nephrology, 2019 BACKGROUND AND OBJECTIVES Atypical hemolytic uremic syndrome is a form of thrombotic microangiopathy caused by dysregulation of the alternative complement pathway. There is evidence showing complement activation in other thrombotic microangiopathies. The
M. Palomo +36 more
semanticscholar +10 more sources
Complement activation in placental malaria [PDF]
Frontiers in Microbiology, 2015 Sixty percent of all pregnancies worldwide occur in malaria endemic regions. Pregnant women are at greater risk of malaria infection than their non-pregnant counterparts and are more likely to develop severe disease.
Chloe Ross McDonald +2 more
doaj +5 more sources
A Review of Complement Activation in SLE [PDF]
Current Rheumatology Reports, 2021 Purpose of Review Complement activation is a key event in the pathogenesis of tissue inflammation and injury in systemic lupus erythematosus (SLE). This review is aimed at comparing the usefulness of measurement of complement proteins in serum/plasma (C3,
A. Weinstein, R. Alexander, D. Zack
semanticscholar +4 more sources
Overview of Complement Activation and Regulation [PDF]
Seminars in Nephrology, 2013 SummaryComplement is an important component of the innate immune system that is crucial for defense from microbial infections and for clearance of immune complexes and injured cells.
Noris, Marina, Remuzzi, Giuseppe
core +4 more sources
Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins
Frontiers in Immunology, 2021 Early and persistent activation of complement is considered to play a key role in the pathogenesis of COVID-19. Complement activation products orchestrate a proinflammatory environment that might be critical for the induction and maintenance of a severe ...
Youssif M. Ali +8 more
semanticscholar +1 more source
Nanoparticle-Induced Complement Activation: Implications for Cancer Nanomedicine
Frontiers in Immunology, 2021 Nanoparticle-based anticancer medications were first approved for cancer treatment almost 2 decades ago. Patients benefit from these approaches because of the targeted-drug delivery and reduced toxicity, however, like other therapies, adverse reactions ...
N. M. La‐Beck +2 more
semanticscholar +1 more source
Factors affecting IgG4-mediated complement activation
Frontiers in Immunology, 2023 Of the four human immunoglobulin G (IgG) subclasses, IgG4 is considered the least inflammatory, in part because it poorly activates the complement system.
Nienke Oskam +13 more
doaj +1 more source
Inside-Out of Complement in Cancer
Frontiers in Immunology, 2022 The role of complement in cancer has received increasing attention over the last decade. Recent studies provide compelling evidence that complement accelerates cancer progression.
Martin Kolev +5 more
doaj +1 more source