Results 21 to 30 of about 275,985 (253)

MHC-matched induced pluripotent stem cells can attenuate cellular and humoral immune responses but are still susceptible to innate immunity in pigs. [PDF]

PLoS ONE, 2014
Recent studies have revealed negligible immunogenicity of induced pluripotent stem (iPS) cells in syngeneic mice and in autologous monkeys. Therefore, human iPS cells would not elicit immune responses in the autologous setting.
Yoshihisa Mizukami, Tomoyuki Abe, Hiroaki Shibata, Yukitoshi Makimura, Shuh-hei Fujishiro, Kimihide Yanase, Shuji Hishikawa, Eiji Kobayashi, Yutaka Hanazono   +8 more
doaj   +1 more source

Plasma complement biomarkers distinguish multiple sclerosis and neuromyelitis optica spectrum disorder [PDF]

, 2016
Background: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are autoimmune demyelinating diseases distinguished clinically by selective involvement in NMOSD of optic nerves and spinal cord. Early clinical manifestations are
Evans, David R. S., Hakobyan, Svetlana, Harding, Katharine, Loveless, Samantha, Luppe, Sebastian, Morgan, Bryan Paul, Robertson, Neil P.   +6 more
core   +1 more source

Preferential association of hepatitis C virus with CD19+ B cells is mediated by complement system [PDF]

, 2016
Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood.
Alter, Harvey J., Baré, Patricia, De Giorgi, Valeria, Grandinetti, Teresa, Matsuura, Kentaro, Salam, Kazi Abdus, Schechterly, Cathy, Wang, Richard   +7 more
core   +1 more source

Blockade of the kallikrein-kinin system reduces endothelial complement activation in vascular inflammationResearch in context

EBioMedicine, 2019
Background: The complement and kallikrein-kinin systems (KKS) are activated during vascular inflammation. The aim of this study was to investigate if blockade of the KKS can affect complement activation on the endothelium during inflammation.
Ingrid Lopatko Fagerström, Anne-lie Ståhl, Maria Mossberg, Ramesh Tati, Ann-Charlotte Kristoffersson, Robin Kahn, Jean-Loup Bascands, Julie Klein, Joost P. Schanstra, Mårten Segelmark, Diana Karpman   +10 more
doaj   +1 more source

The carbohydrate-linked phosphorylcholine of the parasitic nematode product ES-62 modulates complement activation [PDF]

, 2016
Parasitic nematodes manufacture various carbohydratelinked phosphorylcholine (PCh)-containing molecules, including ES-62, a protein with an N-linked glycan terminally substituted with PCh.
Ahmed, Umul Kulthum, Al-Riyami, Lamyaa, Harnett, William, Iqbal, Asif J., Maller, N. Claire, Raynes, John G.   +5 more
core   +1 more source

Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface.

PLoS Pathogens, 2017
Whooping cough, or pertussis, is a contagious disease of the respiratory tract that is re-emerging worldwide despite high vaccination coverage. The causative agent of this disease is the Gram-negative Bordetella pertussis. Knowledge on complement evasion
Elise S Hovingh, Bryan van den Broek, Betsy Kuipers, Elena Pinelli, Suzan H M Rooijakkers, Ilse Jongerius   +5 more
doaj   +1 more source

C1 esterase inhibitor reduces lower extremity ischemia/reperfusion injury and associated lung damage.

PLoS ONE, 2013
BackgroundIschemia/reperfusion injury of lower extremities and associated lung damage may result from thrombotic occlusion, embolism, trauma, or surgical intervention with prolonged ischemia and subsequent restoration of blood flow.
Claudia Duehrkop, Yara Banz, Rolf Spirig, Sylvia Miescher, Marc W Nolte, Martin Spycher, Richard A G Smith, Steven H Sacks, Robert Rieben   +8 more
doaj   +1 more source

Proteomic profiling of IgA nephropathy reveals distinct molecular prognostic subtypes

iScience, 2023
Summary: IgA nephropathy (IgAN) is a heterogeneous disease, which poses a series of challenges to accurate diagnosis and personalized therapy. Herein, we constructed a systematic quantitative proteome atlas from 59 IgAN and 19 normal control donors ...
Xizhao Chen, Mansheng Li, Songbiao Zhu, Yang Lu, Shuwei Duan, Xu Wang, Yong Wang, Pu Chen, Jie Wu, Di Wu, Zhe Feng, Guangyan Cai, Yunping Zhu, Haiteng Deng, Xiangmei Chen   +14 more
doaj   +1 more source

Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma [PDF]

, 2016
BACKGROUND: Glaucoma is a complex, multifactorial disease characterised by the loss of retinal ganglion cells and their axons leading to a decrease in visual function.
B Paul Morgan, Gareth R. Howell, James E. Morgan, James R. Tribble, Keating W. Pepper, Pete A. Williams, Simon W. M. John, Stephen D. Cross   +7 more
core   +3 more sources

C1 inhibitor in canine intravascular hemolysis (C1INCH): study protocol for a randomized controlled trial

BMC Veterinary Research, 2019
Background Immune-mediated hemolytic anemia (IMHA) is a common disease that affects all breeds of dogs and is associated with significant morbidity and mortality.
Robert Goggs, Erica Behling-Kelly
doaj   +1 more source