Results 71 to 80 of about 5,097 (156)

DNA methylome analysis reveals epigenetic alteration of complement genes in advanced metabolic dysfunction-associated steatotic liver disease [PDF]

Clinical and Molecular Hepatology
Background/Aims Blocking the complement system is a promising strategy to impede the progression of metabolic dysfunction–associated steatotic liver disease (MASLD). However, the interplay between complement and MASLD remains to be elucidated.
Amal Magdy, Hee-Jin Kim, Hanyong Go, Jun Min Lee, Hyun Ahm Sohn, Keeok Haam, Hyo-Jung Jung, Jong-Lyul Park, Taekyeong Yoo, Eun-Soo Kwon, Dong Hyeon Lee, Murim Choi, Keon Wook Kang, Won Kim, Mirang Kim, on behalf of the Innovative Target Exploration of NAFLD (ITEN) Consortium   +15 more
doaj   +1 more source

Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r [PDF]

Biochemical Journal, 1986
The sequencing of human liver cDNA clones encoding the entire C1r precursor protein has confirmed the previously determined peptide sequence and has shown that there is a leader peptide which is 17 amino acids long. A residue tentatively identified as beta-hydroxyaspartic acid [Arlaud, Willis & Gagnon (1986) Biochem.
Journet, Agnès, Tosi, Mario
openaire   +2 more sources

Managing Primary Immunodeficiency Immunoglobulin Replacement Therapy‐Related Adverse Events With Recombinant Human C1 Esterase Inhibitor Prophylaxis: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Immunoglobulin replacement therapy (IRT) for primary immunodeficiency reduces infection risk and subsequent complications and can be lifesaving. However, IRT can cause severe systemic adverse events (AEs) that may limit adequate dosing. These AEs may be caused, in part, by activation and/or consumption of complement proteins, thereby lowering ...
Douglas H. Jones, Heidi Memmott
wiley   +1 more source

The Complement System in ANCA‐Associated Vasculitis: Mechanistic Insights, Therapeutic Horizons, and Unmet Clinical Needs

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
Complement activation, particularly via the alternative pathway, drives inflammation and organ damage in ANCA‐associated vasculitis. This review highlights mechanistic insights, tissue and biomarker evidence, and clinical implications of targeting the C5a–C5aR1 axis.
Kehinde Sunmboye, Pauline Millan
wiley   +1 more source

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Biosynthetic homeostasis and resilience of the complement system in health and infectious diseaseResearch in context

EBioMedicine, 2019
Background: The complement system is a central component of the innate immune system. Constitutive biosynthesis of complement proteins is essential for homeostasis.
Esther Willems, Wynand Alkema, Jenneke Keizer-Garritsen, Anouk Suppers, Michiel van der Flier, Ria H.L.A. Philipsen, Lambert P. van den Heuvel, Elena Volokhina, Renate G. van der Molen, Jethro A. Herberg, Michael Levin, Victoria J. Wright, Inge M.L. Ahout, Gerben Ferwerda, Marieke Emonts, Navin P. Boeddha, Irene Rivero-Calle, Federico Martinon Torres, Hans J.C.T. Wessels, Ronald de Groot, Alain J. van Gool, Jolein Gloerich, Marien I. de Jonge   +22 more
doaj   +1 more source

Differential Proteomics of Large Extracellular Vesicles in Ovarian Cancer

PROTEOMICS, Volume 26, Issue 2-3, Page 95-104, February 2026.
ABSTRACT Diverse extracellular vesicles (EVs) are present in all body fluids; however, knowledge of large EVs (lEVs) remains limited. Molecular EV profiles vary depending on EV size and the physiological circulatory system, even within the same patient. In this study, we aimed to characterize the proteomic profile of IEVs in ovarian cancer patients and
Kazuhiro Suzuki, Yusuke Yamamoto, Masami Kitagawa, Eri Asano‐Inami, Kosuke Yoshida, Hiroaki Kajiyama, Akira Yokoi   +6 more
wiley   +1 more source

Proteomic profiling of human plasma extracellular vesicles identifies PF4 and C1R as novel biomarker in sarcopenia

Journal of Cachexia, Sarcopenia and Muscle
Background Sarcopenia, the gradual and generalized loss of muscle mass and function with ageing, is one of the major health problems in older adults, given its high prevalence and substantial socioeconomic implications.
Paula Aparicio, David Navarrete‐Villanueva, Alba Gómez‐Cabello, Tresa López‐Royo, Enrique Santamaría, Joaquín Fernández‐Irigoyen, Karina Ausín, Manuel Arruebo, Victor Sebastian, Germán Vicente‐Rodríguez, Rosario Osta, Raquel Manzano   +11 more
doaj   +1 more source

Clinical and Genetic Spectrum of a Large Cohort With Total and Sub-total Complement Deficiencies

Frontiers in Immunology, 2019
The complement system is crucial for defense against pathogens and the removal of dying cells or immune complexes. Thus, clinical indications for possible complete complement deficiencies include, among others, recurrent mild or serious bacterial ...
Carine El Sissy, Jérémie Rosain, Paula Vieira-Martins, Pauline Bordereau, Aurélia Gruber, Magali Devriese, Loïc de Pontual, Muhamed-Kheir Taha, Claire Fieschi, Claire Fieschi, Capucine Picard, Capucine Picard, Véronique Frémeaux-Bacchi, Véronique Frémeaux-Bacchi   +13 more
doaj   +1 more source

Complement activation in tumor microenvironment after neoadjuvant therapy and its impact on pancreatic cancer outcomes

npj Precision Oncology
Neoadjuvant therapy (NAT) is increasingly being used for pancreatic ductal adenocarcinoma (PDAC). This study investigates how NAT differentially impacts PDAC’s carcinoma cells and the tumor microenvironment (TME).
Xiaofei Zhang, Ruoxin Lan, Yongjun Liu, Venu G. Pillarisetty, Danting Li, Chaohui L. Zhao, Suparna A. Sarkar, Weiguo Liu, Iman Hanna, Mala Gupta, Cristina Hajdu, Jonathan Melamed, Michael Shusterman, Jessica Widmer, John Allendorf, Yao-Zhong Liu   +15 more
doaj   +1 more source