Results 111 to 120 of about 610,146 (137)

The grand escape - how pathogens outsmart the human complement system. [PDF]

Immunobiology
Nowacka AA, Sordo Vieira L, Petr V, Fageräng B, Würzner R, Ohms M.   +5 more
europepmc   +1 more source

Paroxysmal Nocturnal Hemoglobinuria: Unraveling Its Molecular Pathogenesis and Advancing Targeted Therapeutic Strategies. [PDF]

Diseases
Apostolidou E, Georgoulis V, Leonardos D, Kapsali E, Hatzimichael E.   +4 more
europepmc   +1 more source

Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions. [PDF]

Compr Physiol
Zhang H, Prasad RR, Prasad RR, Kumar S, Li M, Jones D, Hu CJ, Mickael C, Yu YR, Tuder RM, Stenmark KR.   +10 more
europepmc   +1 more source

Complement and inflammasome crosstalk in chronic inflammation. [PDF]

Front Immunol
Janžič L, Kouter K.
europepmc   +1 more source

In situ assessment of glomerular C3/C5 convertases indicates ongoing complement activation in IgA nephropathy

Nephrology Dialysis Transplantation
ABSTRACT Background and hypothesis The complement system contributes to the progression of immunoglobulin A nephropathy (IgAN) and offers promising therapeutic targets currently under investigation. Identifying appropriate candidates for these treatments is now critical.
Sophie Caillard, Véronique Frémeaux-Bacchi, Anna Duval   +2 more
exaly   +5 more sources

A novel method for direct measurement of complement convertases activity in human serum

Clinical and Experimental Immunology, 2014
Item does not contain fulltextComplement convertases are enzymatic complexes that play a central role in sustaining and amplification of the complement cascade.
Margarita Lopez-Trascasa, Elena Volokhina, Kevin J Marchank   +2 more
exaly   +2 more sources

Convertase Inhibitory Properties of Staphylococcal Extracellular Complement-binding Protein

Journal of Biological Chemistry, 2010
The human pathogen Staphylococcus aureus secretes several complement evasion molecules to combat the human immune response. Extracellular complement-binding protein (Ecb) binds to the C3d domain of C3 and thereby blocks C3 convertases of the alternative ...
Jos A G van Strijp, Brandon Garcia, Ilse Jongerius   +2 more
exaly   +2 more sources

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The C3/C5 convertase of the alternative pathway of complement: Stabilization and restriction of control by lanthanide ions

Molecular Immunology, 1983
The alternative pathway C3 convertase (C3b,Bb) is a Mg-dependent, labile enzyme with a t/2 of 3 min at 37 degrees C and of 14 min at 24 degrees C (at half physiological ionic strength). To stabilize the enzyme, metal ions of the lanthanide series were tested.
Z, Fishelson, H J, Müller-Eberhard
openaire   +2 more sources

Activation of the Classical Complement Pathway by Nephritic Factor Bound to the Alternative Pathway C3/C5 Convertase

The Journal of Immunology, 1979
Abstract Nephritic Factor (NF), the potent alternative pathway activator, which is occasionally found in association with certain types of nephritis has recently been identified as an IgG class autoantibody specific for the C3 convertase of the alternative pathway.
A T, Sobel, N R, Cooper, R D, Schreiber
openaire   +2 more sources