Complement c3-c5 convertases - Open Access .click

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A Novel Approach to Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH): Both Hemolysis and C3 Deposition Are Blocked by a Monoclonal Antibody (mAb) Specific for the Alternative Pathway of Complement (APC) C3/C5 Convertase.

Blood, 2009
Abstract Abstract 157 In PNH, red blood cells (RBCs) lack key complement control proteins, CD55 and CD59 and are therefore sensitive to complement activation and intravascular hemolysis. These regulatory proteins function at two different steps in the complement cascade; CD55 (decay accelerating factor, DAF) controls the ...
Ronald P Taylor +3 more
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Trypanosoma lewisi: restriction of alternative complement pathway C3/C5 convertase activity.

Experimental parasitology, 1987
The rat parasite Trypanosoma lewisi was incubated in vitro with rat or human serum, washed, and extracted in detergent. Extracts were fractionated by electrophoresis in denaturing gels, transferred to nitrocellulose, allowed to renature, then immunoblotted with polyclonal antibodies to rat complement component C3 and human complement components C3, C5,
J E, Sturtevant, A E, Balber
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Regulation of the C3 nephritic factor stabilized C3/C5 convertase of complement by purified human erythrocyte C3b receptor.

Clinical and experimental immunology, 1983
Activation of complement may result in the generation of the amplification convertase C3bBb. This convertase can be stabilized by properdin (P) or C3NeF. C3bBbP is susceptible to inactivation by beta 1H, while C3bBbNeF is relatively resistant. Since it has been shown that the human erythrocyte C3b receptor (CR1) is able to inactivate C3bBbP, the ...
M R, Daha, D J, Kok, L A, Van Es
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The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases

Frontiers in Immunology, 2021
Harris Gelbard, Jennetta Hammond, Jenny Gunnersen +2 more
exaly

Complement Component C2: the Classical and Lectin Pathway C3/C5 Convertases

2013
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Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases

Nature Immunology, 2005
Jos A G van Strijp, Robert Sim, Suzan Rooijakkers +2 more
exaly

Structure/function of C5 convertases of complement

International Immunopharmacology, 2001
Michael K Pangburn, Nenoo Rawal, M K Pangburn +2 more
exaly

Substrate recognition by complement convertases revealed in the C5–cobra venom factor complex

EMBO Journal, 2011
Gregers Rom Andersen +2 more
exaly

Activation of Complement Component C5

Journal of Biological Chemistry, 2008
Nenoo Rawal
exaly