Results 121 to 130 of about 3,146 (147)

Complement activation in immunological neurological disorders: mechanisms and therapeutic strategies. [PDF]

Front Neurol
Chen JY, Sanghani N, Palmer K, Li Y, Lin F, Abbatemarco JR.   +5 more
europepmc   +1 more source

Targeting C3a and C5a Signaling-A Game Changer for Cancer Therapy? [PDF]

Biology (Basel)
Hudgins H, Molina V, Wiernicki S, Okwuegbe K, Feng X, Wang H.   +5 more
europepmc   +1 more source

A Targeted Blockade of Terminal C5a Is Critical to Management of Sepsis and Acute Respiratory Distress Syndrome: The Mechanism of Action of Vilobelimab. [PDF]

Int J Mol Sci
McCarthy MW, Chong C, Riedemann NC, Guo R.   +3 more
europepmc   +1 more source

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In situ assessment of glomerular C3/C5 convertases indicates ongoing complement activation in IgA nephropathy

Nephrology Dialysis Transplantation
ABSTRACT Background and hypothesis The complement system contributes to the progression of immunoglobulin A nephropathy (IgAN) and offers promising therapeutic targets currently under investigation. Identifying appropriate candidates for these treatments is now critical.
Marie-Sophie Meuleman, Jérôme Olagne, Anne Grünenwald   +2 more
exaly   +4 more sources

A novel method for direct measurement of complement convertases activity in human serum

Clinical and Experimental Immunology, 2014
Item does not contain fulltextComplement convertases are enzymatic complexes that play a central role in sustaining and amplification of the complement cascade.
Anna M Blom, Elena B Volokhina, Margarita Lopez-Trascasa   +2 more
exaly   +2 more sources

Convertase Inhibitory Properties of Staphylococcal Extracellular Complement-binding Protein

Journal of Biological Chemistry, 2010
The human pathogen Staphylococcus aureus secretes several complement evasion molecules to combat the human immune response. Extracellular complement-binding protein (Ecb) binds to the C3d domain of C3 and thereby blocks C3 convertases of the alternative ...
Ilse Jongerius, Brandon L Garcia, Brian V Geisbrecht   +2 more
exaly   +2 more sources

The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases [PDF]

Frontiers in Immunology, 2021
The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Gelbard Harris A, Jenny M Gunnersen, Harris A Gelbard   +2 more
exaly   +2 more sources

The C3/C5 convertase of the alternative pathway of complement: Stabilization and restriction of control by lanthanide ions

Molecular Immunology, 1983
The alternative pathway C3 convertase (C3b,Bb) is a Mg-dependent, labile enzyme with a t/2 of 3 min at 37 degrees C and of 14 min at 24 degrees C (at half physiological ionic strength). To stabilize the enzyme, metal ions of the lanthanide series were tested.
Z, Fishelson, H J, Müller-Eberhard
openaire   +2 more sources

Testing the Activity of Complement Convertases in Serum/Plasma for Diagnosis of C4NeF-Mediated C3 Glomerulonephritis

Journal of Clinical Immunology, 2016
11 p.-4 fig.-1 tab.Autoantibodies termed C3-nephritic factor (C3NeF), which stabilize convertases of the alternative complement pathway, often stimulate autoinflammatory diseases.However, knowledge about analogous autoantibodies acting on the classical ...
Anna M Blom, Fernando Corvillo, Michal Magda   +2 more
exaly   +2 more sources