Spatial heterogeneity in microglia-complement crosstalk: Implications for synaptic pruning in Alzheimer's disease. [PDF]
Alzheimers DementAbstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by synaptic loss, as a key pathological feature in its early stages. Recent studies have highlighted the central role of microglia–complement interactions in synaptic pruning.
Ye Q +10 more
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The Complement System in ANCA-Associated Vasculitis: Mechanistic Insights, Therapeutic Horizons, and Unmet Clinical Needs. [PDF]
Immun Inflamm DisComplement activation, particularly via the alternative pathway, drives inflammation and organ damage in ANCA‐associated vasculitis. This review highlights mechanistic insights, tissue and biomarker evidence, and clinical implications of targeting the C5a–C5aR1 axis.
Sunmboye K, Millan P.
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Induction of immune cytolysis: tumor-cell killing by complement is initiated by covalent complex of monoclonal antibody and stable C3/C5 convertase. [PDF]
Proceedings of the National Academy of Sciences, 1981 The unique specificity of monoclonal antibodies (Ab) was combined with the cell-killing function of the cytolytic alternative pathway of complement. The functionally C3b-like glycoprotein of cobra venom was linked to a murine monoclonal Ab directed to a human melanoma-associated antigen by a disulfide bond, by using a heterobifunctional crosslinking ...
C W, Vogel, H J, Müller-Eberhard
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Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces
Frontiers in Immunology, 2021 To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators.
Arthur Dopler +10 more
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Scientific Reports, 2021 The complement system is a potent mediator of ischemia–reperfusion injury (IRI), which detrimentally affects the function and survival of transplanted kidneys.
Anjan K. Bongoni +10 more
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Frontiers in Immunology, 2018 Complement is essential for the protection against infections; however, dysregulation of complement activation can cause onset and progression of numerous inflammatory diseases.
Seline A. Zwarthoff +8 more
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C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases
Frontiers in Immunology, 2019 C3 glomerulopathy (C3G) is a severe kidney disease, which is caused by defective regulation of the alternative complement pathway. Disease pathogenesis is heterogeneous and is caused by both autoimmune and genetic factors.
Fei Zhao +13 more
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Frontiers in Immunology, 2020 The complement system alternative pathway (AP) can be activated excessively in inflammatory diseases, particularly when there is defective complement regulation.
Jin Y. Chen +8 more
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Nephritic Factors: An Overview of Classification, Diagnostic Tools and Clinical Associations
Frontiers in Immunology, 2019 Nephritic factors comprise a heterogeneous group of autoantibodies against neoepitopes generated in the C3 and C5 convertases of the complement system, causing its dysregulation.
Fernando Corvillo +11 more
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C3 glomerulonephritis with genetically confirmed C3 deficiency in a pediatric patient: a case report [PDF]
Childhood Kidney DiseasesComplement component 3 glomerulonephritis (C3GN) is a rare kidney disease characterized by complement dysregulation that results in prominent complement component 3 (C3) deposition in the kidneys. The clinical course of C3GN varies from mild hematuria to
Hae Min Kim +8 more
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