Vesiculation as potential novel pathogenic mechanism in autoimmune hemolytic anemia
Transfusion, EarlyView.Abstract Background Autoimmune hemolytic anemia (AIHA) is typically mediated by immunoglobulin G (IgG) or immunoglobulin M (IgM) antibodies, and more rarely by immunoglobulin A (IgA). The mechanism of red blood cell (RBC) destruction in IgA‐mediated AIHA is not well understood.
Esther C. W. de Boer +14 more
wiley +1 more source
ACR Open Rheumatology, Volume 7, Issue 5, May 2025.Objective This study aims to investigate whether V‐set Ig domain‐containing protein 4 (VSIG4; also known as complement receptor of the Ig superfamily [CRIg]) forms immune complexes (ICxs) with IgG and complement component 3 (C3) in the kidneys of patients with lupus nephritis (LN) and to assess the potential of urinary VSIG4 and VSIG4‐ICx as ...
Aygun Teymur +6 more
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Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood. [PDF]
Front Immunol, 2022 Landsem A +8 more
europepmc +1 more source
Identification of the C3b receptor-binding domain in third component of complement.
Journal of Biological Chemistry, 1988 We report here that complement receptor type one (CR1) binds to a region of C3b that is contained within the NH2 terminus of the alpha' chain. In an enzyme-linked immunosorbent assay, CR1 bound to C3b, iC3b, and C3c but not to C3d, and this binding was inhibited by soluble C3b and C3c. Further attempts to generate a small C3 fragment capable of binding
John D. Lambris, J D Becherer
openaire +3 more sources
Nuclear complement C3b promotes paclitaxel resistance by assembling the SIN3A/HDAC1/2 complex in non-small cell lung cancer. [PDF]
Cell Death Dis, 2023 Wang X +15 more
europepmc +1 more source
Pattern of degradation of human complement fragment, C3b [PDF]
FEBS Letters, 1981 Andrew B. Wood +3 more
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Intracellular degradation of the complement C3b/C4b receptor in the absence of ligand.
Journal of Biological Chemistry, 1988 Human neutrophils (PMN) respond to various soluble stimuli by translocating intracellular complement C3b/C4b receptors (CR1) to the cell surface. Ligand-independent internalization of surface CR1 has been demonstrated previously, but the fate of total cellular CR1 during PMN stimulation has not been determined.
Jerrold R. Turner +2 more
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Enhanced expression of human monocyte complement (C3b) receptors by chemoattractants. [PDF]
Clinical and experimental immunology, 1980 The capacity of various leucoattractants to enhance, or unfold, receptors for complement (C3b) on human blood monocytes has been studied. A number of recognized monocyte chemoattractants including casein, supernatants from C. parvum 10390 and from human lymphocytes (cultured either in the presence or absence of phytohaemagglutinin) and the formyl ...
GLASS, EJ, KAY, AB
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Factor H binding proteins protect division septa on encapsulated Streptococcus pneumoniae against complement C3b deposition and amplification. [PDF]
Nat Commun, 2018 Pathak A +7 more
europepmc +1 more source
Evasion of serum antibodies and complement by Salmonella Typhi and Paratyphi A. [PDF]
PLoS PathogGuerra FE +3 more
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