Results 41 to 50 of about 792,617 (213)

Interaction of uromodulin and complement factor H enhances C3b inactivation [PDF]

Journal of Cellular and Molecular Medicine, 2016
AbstractRecent studies suggest that uromodulin plays an important role in chronic kidney diseases. It can interact with several complement components, various cytokines and immune system cells. Complement factor H (CFH), as a regulator of the complement alternative pathway, is also associated with various renal diseases.
Liu, Maojing, Wang, Yaqin, Wang, Fengmei, Xia, Min, Liu, Ying, Chen, Yuqing, Zhao, Ming‐Hui   +6 more
openaire   +2 more sources

Inhibition of neutrophil function by fluid phase C3b of complement [PDF]

Infection and Immunity, 1983
A high-molecular-weight fragment of C3 was isolated from normal human serum by column chromatography, was generated by incubation of serum at 37 degrees C with inulin, and was produced from highly purified C3 by limited digestion with trypsin. This product was shown to inhibit the antibacterial function of neutrophils by using Escherichia coli O75 as ...
J D, Ogle, C K, Ogle, J W, Alexander
openaire   +2 more sources

Role of Electrostatic Hotspots in the Selectivity of Complement Control Proteins Toward Human and Bovine Complement Inhibition

Frontiers in Molecular Biosciences, 2021
Poxviruses are dangerous pathogens, which can cause fatal infection in unvaccinated individuals. The causative agent of smallpox in humans, variola virus, is closely related to the bovine vaccinia virus, yet the molecular basis of their selectivity is ...
Yogesh B. Narkhede, Avneesh K. Gautam, Rohaine V. Hsu, Wilson Rodriguez, Nehemiah T. Zewde, Reed E. S. Harrison, Pablo R. Arantes, Zied Gaieb, Ronald D. Gorham, Chris Kieslich, Chris Kieslich, Dimitrios Morikis, Arvind Sahu, Giulia Palermo, Giulia Palermo   +14 more
doaj   +1 more source

Synovial Complement Factors in Patients with Periprosthetic Joint Infection after Undergoing Revision Arthroplasty of the Hip or Knee Joint

Diagnostics, 2021
The role and diagnostic value of the synovial complement system in patients with low-grade periprosthetic joint infection (PJI) are unclear. We sought to evaluate, for the first time, the usefulness of synovial complement factors in these patients by ...
Frank Sebastian Fröschen, Sophia Schell, Matthias Dominik Wimmer, Gunnar Thorben Rembert Hischebeth, Hendrik Kohlhof, Sascha Gravius, Thomas Martin Randau   +6 more
doaj   +1 more source

Structural Model for Factor X Inhibition of IgM and Complement-Mediated Neutralization of Adenovirus

Viruses, 2023
Adenovirus has strong therapeutic potential as an oncolytic virus and gene therapy vector. However, injecting human species C serotype 5 adenovirus, HAdv-C5, into the bloodstream leads to numerous interactions with plasma proteins that affect viral ...
Nicole Wagner, Dmitry M. Shayakhmetov, Phoebe L. Stewart   +2 more
doaj   +1 more source

Increased deposition of C3b on red cells with low CR1 and CD55 in a malaria-endemic region of western Kenya: Implications for the development of severe anemia

BMC Medicine, 2008
Background Severe anemia due to Plasmodium falciparum malaria is a major cause of mortality among young children in western Kenya. The factors that lead to the age-specific incidence of this anemia are unknown.
Odera Michael M, Adhiambo Christine, Otieno Walter, Odhiambo Collins O, Stoute José A   +4 more
doaj   +1 more source

Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration

Frontiers in Pharmacology, 2020
Dysregulation of the complement system is central to age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Most of the genetic variation associated with AMD resides in complement genes, with the greatest risk ...
Matteo Stravalaci, Matteo Stravalaci, Francesca Davi, Raffaella Parente, Marco Gobbi, Barbara Bottazzi, Alberto Mantovani, Alberto Mantovani, Alberto Mantovani, Anthony J. Day, Simon J. Clark, Simon J. Clark, Mario R. Romano, Mario R. Romano, Antonio Inforzato, Antonio Inforzato   +15 more
doaj   +1 more source

Toxoplasma gondii Recruits Factor H and C4b-Binding Protein to Mediate Resistance to Serum Killing and Promote Parasite Persistence in vivo

Frontiers in Immunology, 2020
Regulating complement is an important step in the establishment of infection by microbial pathogens. Toxoplasma gondii actively resists complement-mediated killing in non-immune human serum (NHS) by inactivating C3b, however the precise molecular basis ...
Patricia M. Sikorski, Patricia M. Sikorski, Alessandra G. Commodaro, Michael E. Grigg   +3 more
doaj   +1 more source

Structure of complement fragment C3b–factor H and implications for host protection by complement regulators [PDF]

Nature Immunology, 2009
Factor H (FH) is an abundant regulator of complement activation and protects host cells from self-attack by complement. Here we provide insight into the regulatory activity of FH by solving the crystal structure of the first four domains of FH in complex with its target, complement fragment C3b.
Wu, Jin, Wu, You-qiang, Ricklin, Daniel, Janssen, Bert J C, Lambris, John D, Gros, Piet   +5 more
openaire   +3 more sources

Molecular mechanism of complement inhibition by the trypanosome receptor ISG65

eLife
African trypanosomes replicate within infected mammals where they are exposed to the complement system. This system centres around complement C3, which is present in a soluble form in serum but becomes covalently deposited onto the surfaces of pathogens ...
Alexander D Cook, Mark Carrington, Matthew K Higgins   +2 more
doaj   +1 more source