Deletion of the complement C5a receptor alleviates the severity of acute pneumococcal otitis media following influenza A virus infection in mice. [PDF]
PLoS ONE, 2014 There is considerable evidence that influenza A virus (IAV) promotes adherence, colonization, and superinfection by S. pneumoniae (Spn) and contributes to the pathogenesis of otitis media (OM).
Hua Hua Tong +8 more
doaj +7 more sources
New insights for C5a and C5a receptors in sepsis [PDF]
Frontiers in Immunology, 2012 The complement system plays a central role in inflammation and immunity. Among the complement activation products, C5a is one of the most potent inflammatory peptides with a broad spectrum of functions.
Hongwei eGao, Chunguang eYan
doaj +4 more sources
Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody [PDF]
Journal of Innate Immunity, 2023 Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer.
Leon Cyranka +6 more
doaj +2 more sources
The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. [PDF]
PLoS ONE, 2008 Sepsis remains a poorly understood, enigmatic disease. One of the cascades crucially involved in its pathogenesis is the complement system. Especially the anaphylatoxin C5a has been shown to have numerous harmful effects during sepsis.
Michael A Flierl +7 more
doaj +3 more sources
Complement C5a Receptor Signaling Alters Stress Responsiveness and Modulates Microglia Following Chronic Stress Exposure [PDF]
Biological Psychiatry Global Open ScienceBackground: Accumulating evidence underscores the pivotal role of heightened inflammation in the pathophysiology of stress-related diseases, but the underlying mechanisms remain elusive.
Hsiao-Jou Cortina Chen +7 more
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Complement C5a Implication in Axonal Growth After Injury [PDF]
CellsComplement C5a protein has been shown to play a major role in tissue regeneration through interaction with its receptor (C5aR) on target cells. Expression of this receptor has been reported in the nervous system which, upon injury, has no treatment to ...
Aurélie Cotten +3 more
doaj +2 more sources
Complement factors C3a and C5a mimick a proinflammatory microenvironment and increase HBV IGRA sensitivity [PDF]
Journal of Translational Medicine, 2019 Background Hepatitis B virus (HBV) infections represent a global health problem and chronic hepatitis B (CHB) leads to liver cirrhosis and hepatocellular carcinoma. Thus, timely diagnosis of hepatitis B is crucial to ensure adequate treatment.
Katharina Bröker +4 more
doaj +2 more sources
The activation of complement C5a-C5aR1 axis in astrocytes facilitates the neuropathogenesis due to EV-A71 infection by upregulating CXCL1 [PDF]
Journal of VirologyEnterovirus A71 (EV-A71) is a common small RNA virus that is highly neuroinvasive. Emerging evidence indicates that the complement fragment C5a and its receptor C5aR1 are important drivers of neuroinflammation.
Peiyu Zhu +9 more
doaj +2 more sources
Blood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Gene. [PDF]
Noncoding RNA, 2022 Emblem Å +7 more
europepmc +3 more sources
Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients. [PDF]
Front Immunol, 2020 Karasu E +9 more
europepmc +2 more sources