Is There a Place for Complement Inhibition with Monoclonal Anti-C5a Antibody Vilobelimab in the Treatment of Patients with ANCA-associated Vasculitis? [PDF]
, 2022 Gatr-Alnada Gheriani +2 more
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Adjunctive Therapies in Periodontitis: Current Concepts and the Future
Journal of Periodontal Research, EarlyView.This graphical abstract summarizes the translational pathway from preclinical research to clinical implementation of adjunctive therapies for periodontitis, highlighting key barriers, innovative therapeutic strategies, and emerging tools that aim to bridge experimental discoveries with patient care.
Rafael Scaf de Molon +4 more
wiley +1 more source
Influence of 17 beta-estradiol, progesterone, and dexamethasone on diapedesis and viability of bovine blood polymorphonuclear leukocytes [PDF]
, 2004 The aim of the current study was to investigate whether polymorphonuclear leukocyte (PMN) diapedesis and viability are influenced by steroid hormones.
Burvenich, Christian +3 more
core +1 more source
Toxoplasma Infection Induces Sustained Up-Regulation of Complement Factor B and C5a Receptor in the Mouse Brain via Microglial Activation: Implication for the Alternative Complement Pathway Activation and Anaphylatoxin Signaling in Cerebral Toxoplasmosis [PDF]
, 2021 Noriko Shinjyo +4 more
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Complement levels in septic primates treated with anti-C5a antibodies
Journal of Surgical Research, 1989 During gram-negative sepsis it is known that endotoxin activates complement by the alternate pathway. The complement anaphylatoxin C5a, a result of this activation, is thought to play a key role in attracting and activating neutrophils in the lungs, leading to the adult respiratory distress syndrome.
D H, Hangen +5 more
openaire +2 more sources
Pteridines, 1993 Preeclampsia is a pregnancy induced hypertensive disease with an incidence of about 5% in primigravida and it significantly contributes to maternal and neonatal morbidity and mortality. The primary cause remains unknown but might be immunologic.
Haeger Magnus +2 more
doaj +1 more source
Expression of C5a and its receptor in canine spontaneous tumours: a preliminary finding [PDF]
, 2016 A study of the development of spontaneous tumours in dogs gives many benefits in oncology research due to the similarity between dog and human cancer in terms of epidemiologic, biologic and clinical features.
Ahmad, Hafandi +7 more
core
Complement C5a-Mediated TAM-ing of Antitumor Immunity Drives Squamous Carcinogenesis [PDF]
, 2018 Dimitrios C. Mastellos +2 more
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Advanced Healthcare Materials, Volume 15, Issue 6, 9 February 2026.Protein corona plays a critical role in the biological behavior of nanoparticles. This study investigates the distribution of complement proteins in soft corona and their impact on the macrophage uptake of polymer nanoparticles. It underlines the significance of soft corona investigation for understanding in vivo performance of nanomedicines.
Ying Qiu +8 more
wiley +1 more source
Skeletal Muscle, 2017 Background The terminal pathway of the innate immune complement system is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Terminal complement activation leads to generation of C5a, which through its receptor, C5aR1, drives immune ...
Haitao A. Wang +4 more
doaj +1 more source