Results 151 to 160 of about 38,195 (255)

Complement C5a inhibition: a new form of COVID-19 treatment for mechanically ventilated patients? [PDF]

Lancet Respir Med, 2022
Kalil AC, Proschan M.
europepmc   +1 more source

139 Complement C5a regulates squamous carcinogenesis [PDF]

Journal of Investigative Dermatology, 2017
T.R. Medler, L.M. Coussens
openaire   +1 more source

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages. [PDF]

J Innate Immun, 2023
Wu KC, Condon ND, Hill TA, Reid RC, Fairlie DP, Lim J.   +5 more
europepmc   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, Volume 59, Issue 2, February 2026.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Valproic acid attenuates cellular senescence in diabetic kidney disease through the inhibition of complement C5a receptors. [PDF]

Sci Rep, 2022
Coughlan MT, Ziemann M, Laskowski A, Woodruff TM, Tan SM.   +4 more
europepmc   +1 more source

Protective Role of Complement C5a in an Experimental Model of <i>Staphylococcus aureus</i> Bacteremia [PDF]

, 2009
Maren von Köckritz‐Blickwede, Stephanie Konrad, Simon J. Foster, J. Engelbert Gessner, Eva Medina   +4 more
openalex   +1 more source

Principles for Optimal Drug Selection in IgA Nephropathy—Time for Integrating Pathogenesis and Clinical Markers to Guide Therapy

Nephrology, Volume 31, Issue 2, February 2026.
ABSTRACT IgA nephropathy is a progressive glomerular disease with a variable clinical course and a substantial risk of progression to end‐stage kidney failure. While proteinuria has long been the central therapeutic target, insights into disease pathogenesis indicate that haematuria should also guide treatment decisions. Based on the pathophysiology of
Yusuke Suzuki
wiley   +1 more source

Stiffness-tuned and ROS-sensitive hydrogel incorporating complement C5a receptor antagonist modulates antibacterial activity of macrophages for periodontitis treatment. [PDF]

Bioact Mater, 2023
Gan Z, Xiao Z, Zhang Z, Li Y, Liu C, Chen X, Liu Y, Wu D, Liu C, Shuai X, Cao Y.   +10 more
europepmc   +1 more source

Blockade of the Complement C5a Receptor Reduces Incisional Allodynia, Edema, and Cytokine Expression [PDF]

, 2006
J. David Clark, Yanli Qiao, Xiangqi Li, Xiaoyou Shi, Martin S. Angst, David C. Yeomans   +5 more
openalex   +1 more source