Results 41 to 50 of about 38,195 (255)

Reduced order modeling and analysis of the human complement system. [PDF]

PLoS ONE, 2017
Complement is an important pathway in innate immunity, inflammation, and many disease processes. However, despite its importance, there are few validated mathematical models of complement activation.
Adithya Sagar, Wei Dai, Mason Minot, Rachel LeCover, Jeffrey D Varner   +4 more
doaj   +1 more source

Role of complement C5a and histones in septic cardiomyopathy. [PDF]

Mol Immunol, 2018
Polymicrobial sepsis (after cecal ligation and puncture, CLP) causes robust complement activation with release of C5a. Many adverse events develop thereafter and will be discussed in this review article. Activation of complement system results in generation of C5a which interacts with its receptors (C5aR1, C5aR2).
Fattahi F, Frydrych LM, Bian G, Kalbitz M, Herron TJ, Malan EA, Delano MJ, Ward PA.   +7 more
europepmc   +4 more sources

Complement C3 serum levels in anorexia nervosa: a potential biomarker for the severity of disease? [PDF]

, 2011
BackgroundAnorexia nervosa carries the highest mortality rate of any psychiatric disorder. Even the most critically ill anorexic patients may present with normal 'standard' laboratory values, underscoring the need for a new sensitive biomarker.
Flierl, Michael A, Gaudiani, Jennifer L, Long, Carlin S, Mehler, Philip S, Sabel, Allison L, Stahel, Philip F   +5 more
core   +2 more sources

Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis

Blood, 2010
AbstractThrombosis is a common complication of end-stage renal disease, particularly in patients on hemodialysis. Although substantial progress has been made in preventing thrombotic complications in various other groups of patients, the mechanisms of thrombosis during hemodialysis require clarification.
Ioannis, Kourtzelis, Maciej M, Markiewski, Michael, Doumas, Stavros, Rafail, Konstantinos, Kambas, Ioannis, Mitroulis, Stelios, Panagoutsos, Ploumis, Passadakis, Vasilios, Vargemezis, Paola, Magotti, Hongchang, Qu, Tom Eirik, Mollnes, Konstantinos, Ritis, John D, Lambris   +13 more
openaire   +4 more sources

Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosis [PDF]

, 2014
The epithelial complement inhibitory proteins (CIPs) cluster of differentiation 46 and 55 (CD46 and CD55) regulate circulating immune complex-mediated complement activation in idiopathic pulmonary fibrosis (IPF). Our previous studies demonstrated that IL-
Cummings, Oscar W., Gracon, Adam, Gu, Hongmei, Mickler, Elizabeth A., Sandusky, George E., Vittal, Ragini, Weber, Daniel J., Wilkes, David S., Woodruff, Trent   +8 more
core   +1 more source

Function, structure and therapeutic potential of complement C5a receptors [PDF]

British Journal of Pharmacology, 2007
Complement fragment (C)5a is a 74 residue pro‐inflammatory polypeptide produced during activation of the complement cascade of serum proteins in response to foreign surfaces such as microorganisms and tissue damaged by physical or chemical injury.
Monk, PN, Scola, A. M., Madala, P., Fairlie, D. P.   +3 more
openaire   +3 more sources

Citrate confers less filter-induced complement activation and neutrophil degranulation than heparin when used for anticoagulation during continuous venovenous haemofiltration in critically ill patients [PDF]

, 2014
Background: During continuous venovenous haemofiltration (CVVH), regional anticoagulation with citrate may be superior to heparin in terms of biocompatibility, since heparin as opposed to citrate may activate complement (reflected by circulating C5a) and
Beelen, R.H.J. (Robert), Beishuizen, A. (Albertus), Girbes, A.R.J. (Armand), Groeneveld, A.B.J. (Johan), Nurmohamed, S.A. (Shaikh Azam), Paauw, N.J. (Nanne), Schilder, L. (Louise), Wee, P.M. (Piet) ter   +7 more
core   +3 more sources

Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo

Journal of Neuroinflammation, 2008
Background The complement system is thought to be involved in the pathogenesis of numerous neurological diseases. We previously reported that pre-treatment of murine cortico-hippocampal neuronal cultures with the complement derived anaphylatoxin C5a ...
Thomas Sunil, Mukherjee Piali, Pasinetti Giulio   +2 more
doaj   +1 more source

The relationship of anti-phospholipase A2 receptor antibody and C5a complement with disease activity and short-term outcome in idiopathic membranous nephropathy

Journal of the Formosan Medical Association, 2019
Background: The binding of anti-phospholipase A2 receptor (anti-PLA2R) antibody to podocyte and complement activation is the mechanisms of idiopathic membranous nephropathy (IMN).
Jyun Ni Chi, Tai Shuan Lai, Ching Fang Wu, Tian Yi Fu, Yu Hsiang Chou, Yen Ling Chiu, Wei Chou Lin, Wen Chih Chiang, Yung Ming Chen, Ming Shiou Wu   +9 more
doaj   +1 more source

C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation [PDF]

, 2015
Complement C1q is the activator of the classical pathway. However, it is now recognized that C1q can exert functions unrelated to complement activation.
Agostinis, C, Botto, M, Bulla, R, Durigutto, P, Guarnotta, C, Ling, GS, Rami, D, Tedesco, F, Tripodo, C, Zorzet, S   +9 more
core   +3 more sources