Results 21 to 30 of about 80,611 (190)
Mechanism of Borrelia immune evasion by FhbA-related proteins.
PLoS Pathogens, 2022 Immune evasion facilitates survival of Borrelia, leading to infections like relapsing fever and Lyme disease. Important mechanism for complement evasion is acquisition of the main host complement inhibitor, factor H (FH). By determining the 2.2 Å crystal
Konstantin Kogan +6 more
doaj +1 more source
Complement evasion by human pathogens [PDF]
Nature Reviews Microbiology, 2008 The human immune system has developed an elaborate network of cascades for dealing with microbial intruders. Owing to its ability to rapidly recognize and eliminate microorganisms, the complement system is an essential and efficient component of this machinery.
John D, Lambris +2 more
openaire +2 more sources
Phylogenomic Diversity Elucidates Mechanistic Insights into Lyme Borreliae-Host Association
mSystems, 2022 Host association—the selective adaptation of pathogens to specific host species—evolves through constant interactions between host and pathogens, leaving a lot yet to be discovered on immunological mechanisms and genomic determinants.
Matthew Combs +13 more
doaj +1 more source
Protein engineering to target complement evasion in cancer. [PDF]
FEBS Lett, 2014 The complement system is composed of soluble factors in plasma that enhance or “complement” immune‐mediated killing through innate and adaptive mechanisms. Activation of complement causes recruitment of immune cells; opsonization of coated cells; and direct killing of affected cells through a membrane attack complex (MAC).
Carter D, Lieber A.
europepmc +4 more sources
Spirochetal Lipoproteins and Immune Evasion. [PDF]
, 2017 Spirochetes are a major threat to public health. However, the exact pathogenesis of spirochetal diseases remains unclear. Spirochetes express lipoproteins that often determine the cross talk between the host and spirochetes.
Boyadjian, Ani +2 more
core +1 more source
Virus complement evasion strategies
Journal of General Virology, 2003 The immune system has a variety of tools at its disposal to combat virus infections. These can be subdivided roughly into two categories: 'first line defence', consisting of the non-specific, innate immune system, and 'adaptive immune response', acquired over time following virus infection or vaccination.
Herman W, Favoreel +3 more
openaire +2 more sources
PLoS ONE, 2017 Bacteria exposed to host serum are subject to the antibacterial effects to the complement system. However, pathogenic microorganisms have evolved mechanisms of evading this immune attack. We have previously demonstrated that at least two R.
Daniel A Garza +2 more
doaj +1 more source
Novel method for detecting complement C3 deposition on Staphylococcus aureus
Scientific Reports, 2022 The primary host response to Staphylococcus aureus infection occurs via complement. Complement is an elegant evolutionarily conserved system, playing essential roles in early defences by working in concert with immune cells to survey, label and destroy ...
Toska Wonfor +5 more
doaj +1 more source
Mechanisms to Evade the Phagocyte Respiratory Burst Arose by Convergent Evolution in Typhoidal Salmonella Serovars. [PDF]
, 2018 Typhoid fever caused by Salmonella enterica serovar (S.) Typhi differs in its clinical presentation from gastroenteritis caused by S. Typhimurium and other non-typhoidal Salmonella serovars.
Bäumler, Andreas J +6 more
core +2 more sources
mBio, 2022 Entamoeba histolytica is the cause of amoebiasis. The trophozoite (amoeba) form of this parasite is capable of invading the intestine and can disseminate through the bloodstream to other organs.
Hannah W. Miller +2 more
doaj +1 more source