Purification of the human complement control protein C3b inactivator [PDF]
Biochemical Journal, 1980 An alternative method of isolation from human plasma is described for C3b inactivator, C3bINA, the proteinase that in conjunction with either beta 1H or C4b-binding protein will hydrolyse respectively C3b or C4b, the activation products of the third, C3 and fourth, C4, components of complement. The purification is by chromatography of plasma on columns
L G, Crossley, R R, Porter
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Structural Complementation of a Monomeric Ribosomal-Inactivating Protein [PDF]
Biophysical Journal, 2013 Exotoxin A (ETA) from the Gram-negative bacterium Pseudomonas aeruginosa is a ribosomal-inactivating protein (RIP) that acts by ADP-ribosylation of the post-translationally modified histidine, diphthamide, in elongation factor 2. Apoptotic cell death typically ensues upon intoxication.
Boland, Erin L. +2 more
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Glycation Inactivation of the Complement Regulatory Protein CD59 [PDF]
Diabetes, 2004 Micro- and macrovascular diseases are major causes of morbidity and mortality in the diabetic population, but the cellular and molecular mechanisms that link hyperglycemia to these complications remain incompletely understood. We proposed that in human diabetes, inhibition by glycation of the complement regulatory protein CD59 increases deposition of ...
Xuebin Qin +7 more
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Complement regulatory proteins are incorporated into lentiviral vectors and protect particles against complement inactivation [PDF]
Gene Therapy, 2004 Lentiviral vectors pseudotyped with G glycoprotein from vesicular stomatitis virus (VSV-G) and baculovirus gp64 are inactivated by human complement. The extent of vector inactivation in serum from individual donors was examined and results showed wide donor-dependent variation in complement sensitivity for VSV-G-pseudotyped lentivectors.
C, Schauber-Plewa +4 more
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Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase [PDF]
Proceedings of the National Academy of Sciences, 2009 Several different families of DNA viruses encode proteins that inactivate the cellular retinoblastoma tumor suppressor protein (pRb), which normally functions to bind E2F transcription factors and restrict expression of genes necessary for cellular processes including DNA replication.
Kamil, Jeremy P. +5 more
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International Brazilian Journal of Urology, 2012 Purpose To investigate the use of ClinProt technique to identify cancer markers in plasma of patients suffering from squamous cell carcinoma of the penis (SCCP). Materials and Methods Plasma of 36 healthy subjects and 25 patients with
Paulo Ornellas +12 more
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Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties [PDF]
Scientific Reports, 2017 AbstractBorrelia (B.) miyamotoi, an emerging tick-borne relapsing fever spirochete, resists complement-mediated killing. To decipher the molecular principles of immune evasion, we sought to identify determinants contributing to complement resistance. Employing bioinformatics, we identified a gene encoding for a putative Factor H-binding protein, termed
Florian Röttgerding +8 more
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The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface [PDF]
Infection and Immunity, 2019 Complement is a critical component of antimicrobial immunity. Various complement regulatory proteins prevent host cells from being attacked.
Kashif S. Haleem +7 more
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Diversity of Sites for Measles Virus Binding and for Inactivation of Complement C3b and C4b on Membrane Cofactor Protein CD46 [PDF]
Journal of Biological Chemistry, 1995 The complement system membrane cofactor protein (MCP) CD46 serves as a C3b/C4b inactivating factor for the protection of host cells from autologous complement attack and as a receptor for measles virus (MV). MCP consists of four short consensus repeats (SCR) which are the predominant extracellular structural motif.
K, Iwata +8 more
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