Results 1 to 10 of about 2,111 (96)

Structural Complementation of a Monomeric Ribosomal-Inactivating Protein [PDF]

Biophysical Journal, 2013
Exotoxin A (ETA) from the Gram-negative bacterium Pseudomonas aeruginosa is a ribosomal-inactivating protein (RIP) that acts by ADP-ribosylation of the post-translationally modified histidine, diphthamide, in elongation factor 2. Apoptotic cell death typically ensues upon intoxication.
Crystal M. Van Dyken, Erin L. Boland, Gregory M.K. Poon   +2 more
openaire   +2 more sources

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]

, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
A Alitalo, A Alitalo, A Alitalo, A Seling, AC Steere, AM Blom, Andreas Klos, AP van Dam, B Stevenson, C Hammerschmidt, C Siegel, C Siegel, Christine Skerka, Claudia Hammerschmidt, CS Brooks, Dania Richter, E Diza, F Strle, Franz-Rainer Matuschka, H Jiang, H Michel, J Hellwage, J Pietikainen, J Potempa, Jasmin Schwab, JD Lambris, JV McDowell, K Hartmann, K Haupt, K Kurtenbach, K Kurtenbach, K Saito, K Whaley, KM Hovis, KP Hunfeld, L Beinrohr, M Collares-Pereira, M Jusko, M Józsi, MJ Walport, MK Pangburn, MR Bhide, MR Bhide, MR Kenedy, MS Metts, N Marr, ND van Burgel, P Herzberger, P Herzberger, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Ramu, Peter F. Zipfel, Peter Kraiczy, PF Zipfel, PF Zipfel, R Dieterich, R Wallich, Reinhard Wallich, RG Discipio, RJ Ziccardi, S Breitner-Ruddock, S Grosskinsky, S Grosskinsky, S Heinen, S Kühn, SC Bock, SG Rijpkema, SH Rooijakkers, T Fujita, T Fujita, V Brade, Y Terao   +76 more
core   +9 more sources

Purification of the human complement control protein C3b inactivator [PDF]

Biochemical Journal, 1980
An alternative method of isolation from human plasma is described for C3b inactivator, C3bINA, the proteinase that in conjunction with either beta 1H or C4b-binding protein will hydrolyse respectively C3b or C4b, the activation products of the third, C3 and fourth, C4, components of complement. The purification is by chromatography of plasma on columns
R R Porter, L G Crossley
openaire   +3 more sources

Complement regulatory proteins are incorporated into lentiviral vectors and protect particles against complement inactivation [PDF]

Gene Therapy, 2004
Lentiviral vectors pseudotyped with G glycoprotein from vesicular stomatitis virus (VSV-G) and baculovirus gp64 are inactivated by human complement. The extent of vector inactivation in serum from individual donors was examined and results showed wide donor-dependent variation in complement sensitivity for VSV-G-pseudotyped lentivectors.
C Schauber-Plewa, A Simmons, Christopher D. Pacheco, G Veres, M J Tuerk   +4 more
openaire   +3 more sources

Glycation Inactivation of the Complement Regulatory Protein CD59 [PDF]

Diabetes, 2004
Micro- and macrovascular diseases are major causes of morbidity and mortality in the diabetic population, but the cellular and molecular mechanisms that link hyperglycemia to these complications remain incompletely understood. We proposed that in human diabetes, inhibition by glycation of the complement regulatory protein CD59 increases deposition of ...
Arthur P. Hays, Jose A. Halperin, Allison B. Goldfine, Xuebin Qin, Michael Chorev, Nicole Krumrei, Juan A. Acosta, Luciano Grubissich   +7 more
openaire   +3 more sources

Diversity of Sites for Measles Virus Binding and for Inactivation of Complement C3b and C4b on Membrane Cofactor Protein CD46 [PDF]

Journal of Biological Chemistry, 1995
The complement system membrane cofactor protein (MCP) CD46 serves as a C3b/C4b inactivating factor for the protection of host cells from autologous complement attack and as a receptor for measles virus (MV). MCP consists of four short consensus repeats (SCR) which are the predominant extracellular structural motif.
Shigeharu Ueda, Peter M. Johnson, Tsukasa Seya, Shigeharu Nagasawa, Yusuke Yanagi, Kazunori Iwata, Hiroyoshi Ariga, Masaru Okabe, John M. Pesando   +8 more
openaire   +3 more sources

Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties [PDF]

Scientific Reports, 2017
AbstractBorrelia (B.) miyamotoi, an emerging tick-borne relapsing fever spirochete, resists complement-mediated killing. To decipher the molecular principles of immune evasion, we sought to identify determinants contributing to complement resistance. Employing bioinformatics, we identified a gene encoding for a putative Factor H-binding protein, termed
Volker Fingerle, Peter Kraiczy, Michael Kirschfink, Florian Röttgerding, Peter F. Zipfel, Peter F. Zipfel, Reinhard Wallich, Alex Wagemakers, Joppe W. Hovius, Joris Koetsveld   +9 more
openaire   +6 more sources

The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface [PDF]

Infection and Immunity, 2019
Complement is a critical component of antimicrobial immunity. Various complement regulatory proteins prevent host cells from being attacked.
Peter W. Andrew, Sven Hammerschmidt, Hasan Yesilkaya, Thomas P. Kohler, Kashif Syed Haleem, Kashif Syed Haleem, Wilhelm J. Schwaeble, Youssif M. Ali, Nicholas J. Lynch   +8 more
openaire   +3 more sources

Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase [PDF]

Proceedings of the National Academy of Sciences, 2009
Several different families of DNA viruses encode proteins that inactivate the cellular retinoblastoma tumor suppressor protein (pRb), which normally functions to bind E2F transcription factors and restrict expression of genes necessary for cellular processes including DNA replication.
Kamil, Jeremy P., Hume, Adam J., Jurak, Igor, Münger, Karl, Kalejta, Robert F., Coen, Donald M.   +5 more
openaire   +5 more sources

Development of covalent inhibitors: Principle, design, and application in cancer

MedComm – Oncology, Volume 2, Issue 4, December 2023., 2023
The noncysteine covalent inhibitors are a class of small molecule inhibitors that can bind irreversibly to their target enzymes through covalent bonding with noncysteine residues. They have shown promise as potential therapeutics for a variety of diseases, including cancer, infectious diseases, and autoimmune disorders. Examples of noncysteine covalent
Lang Zheng, Yang Li, Defa Wu, Huan Xiao, Shilong Zheng, Guan Wang, Qiu Sun   +6 more
wiley   +1 more source