Results 11 to 20 of about 96,307 (191)

Development of Efficient Covalent Inactivators of a Fungal Aspartate Semialdehyde Dehydrogenase. [PDF]

Drug Dev Res
ABSTRACT Aspartate semialdehyde dehydrogenase (ASADH) catalyzes the second step in the fungal pathway towards the synthesis of threonine, isoleucine, and methionine, and it has been identified as a viable target for antifungal drug development. Our previous work produced a group of vinyl sulfones that function as irreversible covalent inactivators of ...
Friday SN, Koellner LA, Brown SW, Calbat CN, Curran CF, Dietz JD, Koenig-Dummer A, Friday PD, Parker JA, Simmons NA, Urmey FA, West AN, Zagler SG, Viola RE, Halkides CJ.   +14 more
europepmc   +2 more sources

Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties [PDF]

Scientific Reports, 2017
AbstractBorrelia (B.) miyamotoi, an emerging tick-borne relapsing fever spirochete, resists complement-mediated killing. To decipher the molecular principles of immune evasion, we sought to identify determinants contributing to complement resistance. Employing bioinformatics, we identified a gene encoding for a putative Factor H-binding protein, termed
Florian Röttgerding, Alex Wagemakers, Joris Koetsveld, Volker Fingerle, Michael Kirschfink, Joppe W. Hovius, Peter F. Zipfel, Reinhard Wallich, Peter Kraiczy   +8 more
openaire   +5 more sources

Downregulation of C3 and C4A/B complement factor fragments in plasma from patients with squamous cell carcinoma of the penis

International Brazilian Journal of Urology, 2012
Purpose To investigate the use of ClinProt technique to identify cancer markers in plasma of patients suffering from squamous cell carcinoma of the penis (SCCP). Materials and Methods Plasma of 36 healthy subjects and 25 patients with
Paulo Ornellas, Antonio Augusto Ornellas, Clizia Chinello, Erica Gianazza, Veronica Mainini, Marta Cazzaniga, Denise Abreu Pereira, Vanessa Sandim, Ana Sheila Cypriano, Leandro Koifman, Paulo Cesar Barbosa da Silva, Gilda Alves, Fulvio Magni   +12 more
doaj   +1 more source

Complement C3 serum levels in anorexia nervosa: a potential biomarker for the severity of disease? [PDF]

, 2011
BackgroundAnorexia nervosa carries the highest mortality rate of any psychiatric disorder. Even the most critically ill anorexic patients may present with normal 'standard' laboratory values, underscoring the need for a new sensitive biomarker.
Flierl, Michael A, Gaudiani, Jennifer L, Long, Carlin S, Mehler, Philip S, Sabel, Allison L, Stahel, Philip F   +5 more
core   +2 more sources

The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface [PDF]

Infection and Immunity, 2019
Complement is a critical component of antimicrobial immunity. Various complement regulatory proteins prevent host cells from being attacked.
Kashif S. Haleem, Youssif M. Ali, Hasan Yesilkaya, Thomas Kohler, Sven Hammerschmidt, Peter W. Andrew, Wilhelm J. Schwaeble, Nicholas J. Lynch   +7 more
openaire   +2 more sources

Development of covalent inhibitors: Principle, design, and application in cancer

MedComm – Oncology, Volume 2, Issue 4, December 2023., 2023
The noncysteine covalent inhibitors are a class of small molecule inhibitors that can bind irreversibly to their target enzymes through covalent bonding with noncysteine residues. They have shown promise as potential therapeutics for a variety of diseases, including cancer, infectious diseases, and autoimmune disorders. Examples of noncysteine covalent
Lang Zheng, Yang Li, Defa Wu, Huan Xiao, Shilong Zheng, Guan Wang, Qiu Sun   +6 more
wiley   +1 more source

Active disassembly of the first complement component, C-1, by C-1 inactivator.

Journal of Immunology, 1979
In order to clarify its mechanism of disassembly, the first component of human complement, C1, was reconstituted from C1q, 125I-C1r, and 131I-C1s. This radiolabeled C1 bound tightly to aggregated IgG covalently linked to Sepharose 4B.
R. Ziccardi, Neil R. Cooper
semanticscholar   +1 more source

Diversity of Sites for Measles Virus Binding and for Inactivation of Complement C3b and C4b on Membrane Cofactor Protein CD46 [PDF]

Journal of Biological Chemistry, 1995
The complement system membrane cofactor protein (MCP) CD46 serves as a C3b/C4b inactivating factor for the protection of host cells from autologous complement attack and as a receptor for measles virus (MV). MCP consists of four short consensus repeats (SCR) which are the predominant extracellular structural motif.
K, Iwata, T, Seya, Y, Yanagi, J M, Pesando, P M, Johnson, M, Okabe, S, Ueda, H, Ariga, S, Nagasawa   +8 more
openaire   +2 more sources

The interaction of C3b bound to pneumococci with factor H (beta 1H globulin), factor I (C3b/C4b inactivator), and properdin factor B of the human complement system.

Journal of Immunology, 1983
Pneumococcal cell walls are potent activators of the alternative complement (C) pathway; pneumococcal capsules are not. C3b that is deposited onto the cell walls of encapsulated organisms, however, functions inefficiently in host defense compared to C3b ...
E. Brown, K. Joiner, T. Gaither, C. Hammer, M. Frank   +4 more
semanticscholar   +1 more source

Human complement factor H [PDF]

, 1986
We isolated cDNA clones coding for the functionally important tryptic N-terminal38- kDa fragment of human complement control protein factor H using polyclonal and monoclonal antibodies to screen a human liver cDNA library cloned in a bacterial expression
Dierich, Manfred P., Schulz, T. F., Schwaeble, W., Stanley, K. K., Weiss, Elisabeth H.   +4 more
core   +1 more source