Results 11 to 20 of about 1,644 (112)
Development of Efficient Covalent Inactivators of a Fungal Aspartate Semialdehyde Dehydrogenase. [PDF]
Drug Dev ResABSTRACT Aspartate semialdehyde dehydrogenase (ASADH) catalyzes the second step in the fungal pathway towards the synthesis of threonine, isoleucine, and methionine, and it has been identified as a viable target for antifungal drug development. Our previous work produced a group of vinyl sulfones that function as irreversible covalent inactivators of ...
Friday SN +14 more
europepmc +2 more sources
Journal of General Virology, 2016 Newcastle disease virus (NDV) is being developed as an oncolytic virus for virotherapy. In this study we analysed the regulation of complement-mediated inactivation of a recombinant NDV in different host cells. NDV grown in human cells was less sensitive to complement-mediated virus inactivation than NDV grown in embryonated chicken eggs. Additionally,
Udaya S, Rangaswamy +4 more
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Author Correction: Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties [PDF]
Scientific Reports, 2019 A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Florian Röttgerding +8 more
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Tumor Cell Complementation Groups Based on Myogenic Potential: Evidence for Inactivation of Loci Required for Basic Helix-Loop-Helix Protein Activity [PDF]
Molecular and Cellular Biology, 1996 Basic helix-loop-helix (bHLH) proteins mediate terminal differentiation in many lineages. By using the bHLH protein MyoD, which can dominantly activate the myogenic differentiation program in numerous cell types, we demonstrated that recessive defects in bHLH protein function are present in human tumor lines. In contrast to prior work with primary cell
A N, Gerber, S J, Tapscott
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Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution. [PDF]
The Journal of experimental medicine, 1977 The complement regulatory enzyme, C3b inactivator (C3bINA), has been purified from human serum by affinity chromatography on an anti-C3bINA Sepharose column. Subsequent chromatography on DEAE-cellulose and removal of IgG with anti-IgG Sepharose resulted in a product which was found to be homogeneous by polyacrylamide gel electrophoresis at pH 8.9 and ...
M K, Pangburn +2 more
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Detection by Paper Electrophoresis of the Protein Denaturation in Heat-inactivated Serum for the Complement Fixation Reaction [PDF]
Nature, 1956 IN seeking the mechanism to explain an apparent procomplementary activity to canine complement of canine serum activated at 56° C. for 30 min., it was observed that the same serum was anticomplementary if inactivated at 62° C. instead of 56° C.
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Medicinal Research Reviews, Volume 45, Issue 6, Page 1662-1678, November 2025.ABSTRACT Molecular imprinting is a very powerful tool in life science. The research areas benefiting from a wide range of capabilities of molecularly imprinted polymeric nanoparticles (nanoMIPs) include sample preparation, extraction, sensing/detection, diagnostics, and drug delivery.
Milada Vodova +2 more
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Food Science &Nutrition, Volume 13, Issue 9, September 2025.Piceatannol significantly inhibits the growth of Helicobacter pylori through targeted suppression of its secreted urease activity. The inhibition of piceatannol against H. pylori urease (HPU) and jack bean urease (JBU) was characterized in a slow‐binding, mixed‐type and slow‐binding, noncompetitive type, respectively.
Qiang Lu +5 more
wiley +1 more source
Beyond the Binary: Controlling Natural Sex‐Change in Hermaphroditic Fishes
Reviews in Aquaculture, Volume 17, Issue 4, September 2025.ABSTRACT Sex‐change in hermaphroditic fishes is a complex but natural biological phenomenon that has significant implications for aquaculture fingerling production, selective breeding, and grow‐out. Understanding the physiological, endocrinological, and molecular pathways underlying hermaphroditism in fishes offers unique opportunities to manipulate ...
Roni Chandra Mondal +3 more
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