Essential role of the CD docking motif of MPK4 in plant immunity, growth, and development
Summary MAPKs are universal eukaryotic signaling factors whose functioning is assumed to depend on the recognition of a common docking motif (CD) by its activators, substrates, and inactivators. We studied the role of the CD domain of Arabidopsis MPK4 by performing interaction studies and determining the ligand‐bound MPK4 crystal structure. We revealed
Anna Siodmak+10 more
wiley +1 more source
The cannabinoid receptor CB1R shows a different time of onset of expression in chicken and frog embryos. This raises the question of whether CB1R regulates similar or distinct processes during the development of these two species. We show that normal activity of CB1R is required for sequential steps in migration and morphogenesis of neural crest cells ...
Amira Mahomed+12 more
wiley +1 more source
Complement C3 serum levels in anorexia nervosa: a potential biomarker for the severity of disease? [PDF]
BackgroundAnorexia nervosa carries the highest mortality rate of any psychiatric disorder. Even the most critically ill anorexic patients may present with normal 'standard' laboratory values, underscoring the need for a new sensitive biomarker.
Flierl, Michael A+5 more
core +2 more sources
Abstract In several regions of Africa, the daily diet is partly dependent on the edible products from wild animals, plants, and mushrooms, driven by their availability, wide distribution in the local environment, and the low incomes of the general population.
Claudete Bastos+4 more
wiley +1 more source
Newcastle disease virus (NDV) is being developed as an oncolytic virus for virotherapy. In this study we analysed the regulation of complement-mediated inactivation of a recombinant NDV in different host cells. NDV grown in human cells was less sensitive to complement-mediated virus inactivation than NDV grown in embryonated chicken eggs. Additionally,
Zhongying Chen+4 more
openaire +3 more sources
CLONING OF THE 1.4-kb mRNA SPECIES OF HUMAN COMPLEMENT FACTOR H REVEALS A NOVEL MEMBER OF THE SHORT CONSENSUS REPEAT FAMILY RELATED TO THE CARBOXY TERMINAL OF THE CLASSICAL 150-kDa MOLECULE [PDF]
Three factor H mRNA species of 4.3 kb, 1.8 kb, and 1.4 kb are constitutively expressed in human liver. Having previously characterized full-length cDNA clones derived from the 4.3-kb and 1.8-kb factor mRNA, we report here the isolation and eucaryotic ...
Dierich, Manfred P.+4 more
core +2 more sources
THE DERIVATION OF TWO DISTINCT ANAPHYLATOXIN ACTIVITIES FROM THE THIRD AND FIFTH COMPONENTS OF HUMAN COMPLEMENT [PDF]
Anaphylatoxin activity was derived from both human C'5 and C'3 molecules. This was achieved in the case of C'5 by interaction with trypsin or with EAC'4, oxy2a, 3.
Cochrane, C. G., Müller-Eberhard, H. J.
core +3 more sources
Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution. [PDF]
The complement regulatory enzyme, C3b inactivator (C3bINA), has been purified from human serum by affinity chromatography on an anti-C3bINA Sepharose column. Subsequent chromatography on DEAE-cellulose and removal of IgG with anti-IgG Sepharose resulted in a product which was found to be homogeneous by polyacrylamide gel electrophoresis at pH 8.9 and ...
Hans J. Müller-Eberhard+2 more
openaire +3 more sources
Detection by Paper Electrophoresis of the Protein Denaturation in Heat-inactivated Serum for the Complement Fixation Reaction [PDF]
IN seeking the mechanism to explain an apparent procomplementary activity to canine complement of canine serum activated at 56° C. for 30 min., it was observed that the same serum was anticomplementary if inactivated at 62° C. instead of 56° C.
openaire +2 more sources
Author Correction: Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties [PDF]
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Alex Wagemakers+9 more
openaire +2 more sources