Results 21 to 30 of about 1,644 (112)

Relevance of G protein‐coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation

British Journal of Pharmacology, Volume 182, Issue 14, Page 3211-3224, July 2025.
Abstract G protein‐coupled receptors (GPCRs) are one of the major drug targets. In recent years, computational drug design for GPCRs has mainly focused on static structures obtained through X‐ray crystallography, cryogenic electron microscopy (cryo‐EM) or in silico modelling as a starting point for virtual screening campaigns. However, GPCRs are highly
Marta Lopez‐Balastegui, Tomasz Maciej Stepniewski, Małgorzata M. Kogut‐Günthel, Antonella Di Pizio, Mette Marie Rosenkilde, Jiafei Mao, Jana Selent   +6 more
wiley   +1 more source

Interaction of S-protein of complement with thrombin and antithrombin III during coagulation. Protection of thrombin by S-protein from antithrombin III inactivation.

Journal of Biological Chemistry, 1986
S-protein, the inhibitor in plasma of the membrane attack complex of complement, appears to have a second function in coagulation. S-protein during clotting enters into a trimolecular complex with thrombin and antithrombin III (ATIII). Functionally, S-protein in the presence of low concentrations of heparin, protects thrombin from inactivation by ATIII.
E R, Podack, B, Dahlbäck, J H, Griffin
openaire   +2 more sources

Lung‐Specific mRNA Delivery by Ionizable Lipids with Defined Structure‐Function Relationship and Unique Protein Corona Feature

Advanced Science, Volume 12, Issue 14, April 10, 2025.
A novel structure‐function relationship is identified for lung‐targeting ionizable lipids with nonpermanent charges. These lipids feature N‐methyl and secondary amine groups in their heads and three tails derived from epoxyalkanes, demonstrating superior pulmonary selectivity and efficiency.
Xiaoyan He, Runyuan Wang, Yan Cao, Yan Ding, Yan Chang, Haoru Dong, Rong Xie, Guisheng Zhong, Huiying Yang, Jianfeng Li   +9 more
wiley   +1 more source

ARHGAP29 promotes keratinocyte proliferation and migration in vitro and is dispensable for in vivo wound healing

Developmental Dynamics, Volume 254, Issue 4, Page 310-329, April 2025.
Abstract Background RhoA GTPases play critical roles in actin cytoskeletal remodeling required for controlling a diverse range of cellular functions including cell proliferation, adhesion, migration and changes in cell shape, all required for cutaneous wound healing.
Lindsey Rhea, Tanner Reeb, Emily Adelizzi, Bailey Garnica, Allison Stein, Alexis Kollash, Elliot Dunnwald, Martine Dunnwald   +7 more
wiley   +1 more source

Baculovirus GP64-pseudotyped HIV-based lentivirus vectors are stabilized against complement inactivation by codisplay of decay accelerating factor (DAF) or of a GP64–DAF fusion protein

Molecular Therapy, 2005
The eventual development of efficient gene transfer vectors for in vivo gene delivery will require the development of a number of important new technologies such as stabilization of vectors against protective mechanisms that destroy or otherwise inactivate foreign infectious agents like gene transfer vectors.
Guibinga, Ghiabe H., Friedmann, Theodore
openaire   +2 more sources

Author Correction: Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties (Scientific Reports, (2017), 7, 1, (303), 10.1038/s41598-017-00412-4)

Scientific reports, 2019
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Röttgerding, Florian, Wagemakers, Alex, Koetsveld, Joris, Fingerle, Volker, Kirschfink, Michael, Hovius, Joppe W., Zipfel, Peter F., Wallich, Reinhard, Kraiczy, Peter   +8 more
openaire   +1 more source

A Case of Duodenal Edema-related Undiagnosed Hereditary Angioedema. [PDF]

Intern Med, 2023
Kawara F, Matsuura T, Yamanaka K, Nishioka C.   +3 more
europepmc   +1 more source

Complement system in cancer: friend or foe of immunotherapy. [PDF]

J Immunother Cancer
Shah HK, Prem S, Wu X, Liszewski MK, Atkinson JP, Singh AK, Kapoor V.   +6 more
europepmc   +1 more source

Complement response to burn injury: systematic review and meta-analysis of patient and animal studies. [PDF]

Front Immunol
Mulder PPG, van Hooren M, Bumbuc RV, Hooijmans CR, Korkmaz HI, Boekema BKHL.   +5 more
europepmc   +1 more source

The Impact of Complement Factor H-Related Protein Gene Deletions on Kidney Transplantation. [PDF]

Scand J Immunol
Markkinen S, Lokki AI, Helanterä I, Ritari J, Partanen J, Meri S, Hyvärinen K.   +6 more
europepmc   +1 more source