Results 11 to 20 of about 80,513 (156)

A Case of Neisseria sicca Bacteremia Due to Eculizumab Therapy

Annals of Internal Medicine: Clinical Cases, 2023
Eculizumab is a monoclonal antibody indicated for the treatment of complement-mediated disorders. Despite its utility, eculizumab increases risk for infection with Neisseria species, owing to membrane attack complex inhibition.
Kelly A. Russo, Ted Louie
doaj   +1 more source

Astrocyte- and Neuron-Derived Extracellular Vesicles from Alzheimer’s Disease Patients Effect Complement-Mediated Neurotoxicity

Cells, 2020
We have previously shown that blood astrocytic-origin extracellular vesicles (AEVs) from Alzheimer’s disease (AD) patients contain high complement levels.
Carlos J. Nogueras-Ortiz, Vasiliki Mahairaki, Francheska Delgado-Peraza, Debamitra Das, Konstantinos Avgerinos, Erden Eren, Matthew Hentschel, Edward J. Goetzl, Mark P. Mattson, Dimitrios Kapogiannis   +9 more
doaj   +1 more source

Trichinella spiralis paramyosin binds to C8 and C9 and protects the tissue-dwelling nematode from being attacked by host complement. [PDF]

PLoS Neglected Tropical Diseases, 2011
BACKGROUND: Paramyosin is a thick myofibrillar protein found exclusively in invertebrates. Evidence suggested that paramyosin from helminths serves not only as a structural protein but also as an immunomodulatory agent.
Zhifei Zhang, Jing Yang, Junfei Wei, Yaping Yang, Xiaoqin Chen, Xi Zhao, Yuan Gu, Shijuan Cui, Xinping Zhu   +8 more
doaj   +1 more source

Clinical Isolates of Acinetobacter spp. Are Highly Serum Resistant Despite Efficient Recognition by the Complement System

Frontiers in Immunology, 2022
Gram-negative bacteria from the genus Acinetobacter are responsible for life-threating hospital-related infections such as pneumonia, septicemia, and meningitis, especially in immunocompromised patients.
Michal Magda, Serena Bettoni, Maisem Laabei, Derek Fairley, Thomas A. Russo, Kristian Riesbeck, Anna M. Blom   +6 more
doaj   +1 more source

Hijacking Factor H for Complement Immune Evasion

Frontiers in Immunology, 2021
The complement system is an essential player in innate and adaptive immunity. It consists of three pathways (alternative, classical, and lectin) that initiate either spontaneously (alternative) or in response to danger (all pathways). Complement leads to
Sara R. Moore, Smrithi S. Menon, Claudio Cortes, Viviana P. Ferreira   +3 more
doaj   +1 more source

Complement system activation contributes to the ependymal damage induced by microbial neuraminidase [PDF]

, 2016
Background In the rat brain, a single intracerebroventricular injection of neuraminidase from Clostridium perfringens induces ependymal detachment and death.
A Ascherio, A Vakeva, AH Stephan, AJ Jimenez, B. Paul Morgan, BH Heijnen, BK Rima, BP Morgan, BP Morgan, C Canova, C Casarsa, C Costa, CA Molgaard, D Bhole, D Orth, D Ricklin, DA Lim, DP Schafer, EM Rodriguez, ER Podack, F Doetsch, FH Brennan, G Margolis, H Ninomiya, HJ Muller-Eberhard, IL Graves, J Finsterer, J Li, J Schneider-Schaulies, JE Bruni, Jesús M. Grondona, JJ Alexander, JM Grondona, JM Grondona, JM Grondona, JP Melis, Krista Johnson, L Petit, M Takahashi, María Dolores López-Ávalos, MB Marques, MC Gomez-Roldan, MD Kazatchkine, MG Dixhoorn van, MK Pangburn, MK Pangburn, MK Pangburn, N Donin, N Rawal, OB Spiller, P Gasque, P Granados-Duran, P Paez, Pablo Granados-Durán, Paul P. Tamburini, Pedro Fernández-Llebrez, PF Stahel, PF Stahel, PK Lauf, PL Leenaerts, Q Shi, R Kornfeld, RA Marrie, RG Medicus, RJ Mead, RM Peckham, RP Rother, RT Johnson, RT Johnson, S Kuchler, S Meri, SA Rollins, SA Rollins, SB Laursen, SH Fatemi, SM Lucas, SR Barnum, T Ebert, T Fujita, T Takano, Timothy R. Hughes, V Coskun, V Ramaglia, WA Tompkins, WS Carbonell   +84 more
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Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models

Acta Neuropathologica Communications, 2022
Complement is involved in developmental synaptic pruning and pathological synapse loss in Alzheimer’s disease. It is posited that C1 binding initiates complement activation on synapses; C3 fragments then tag them for microglial phagocytosis. However, the
Sarah M. Carpanini, Megan Torvell, Ryan J. Bevan, Robert A. J. Byrne, Nikoleta Daskoulidou, Takashi Saito, Takaomi C. Saido, Philip R. Taylor, Timothy R. Hughes, Wioleta M. Zelek, B. Paul Morgan   +10 more
doaj   +1 more source

Pseudomonas aeruginosa and the Complement System: A Review of the Evasion Strategies

Microorganisms, 2023
The increasing emergence of multidrug resistant isolates of P. aeruginosa causes major problems in hospitals worldwide. This concern is particularly significant in bloodstream infections that progress rapidly, with a high number of deaths within the ...
Alex González-Alsina, Margalida Mateu-Borrás, Antonio Doménech-Sánchez, Sebastián Albertí   +3 more
doaj   +1 more source

Sublytic Terminal Complement Components Induce Eryptosis in Autoimmune Haemolytic Anaemia Related to IgM Autoantibodies [PDF]

, 2019
BACKGROUND/AIMS: Eryptosis, the suicidal death of red blood cells (RBCs), is characterized by phosphatidylserine (PS) exposure at the cell surface. It can be catalysed by a variety of abnormal conditions and diseases.
Balola, Abdelwahab Hassan Ahmed, Bartolmäs, Thilo, Mayer, Beate, Salama, Abdulgabar   +3 more
core   +1 more source

Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59

Cell Reports, 2013
Pore-forming proteins containing the structurally conserved membrane attack complex/perforin fold play an important role in immunity and host-pathogen interactions.
Steven Johnson, Nicholas J. Brooks, Richard A.G. Smith, Susan M. Lea, Doryen Bubeck   +4 more
doaj   +1 more source