Results 1 to 10 of about 221,380 (236)

The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. [PDF]

PLoS Pathogens, 2012
The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Youssif M Ali, Nicholas J Lynch, Kashif S Haleem, Teizo Fujita, Yuichi Endo, Soren Hansen, Uffe Holmskov, Kazue Takahashi, Gregory L Stahl, Thomas Dudler, Umakhanth V Girija, Russell Wallis, Aras Kadioglu, Cordula M Stover, Peter W Andrew, Wilhelm J Schwaeble   +15 more
doaj   +15 more sources

DYSFUNCTION OF COMPLEMENT SYSTEM IN FAMILIAL MEDITERRANEAN FEVER

Медицинская иммунология, 2014
. During attacks of familial mediterranean fever (FMF), multiple systemic events are triggered, most of which promote autoinflammatory reactions. A molecular pattern of immune abnormalities in FMF is yet unclear.
G. M. Mkrtchyan, L. P. Hovhannisyan, A. A. Ayvazyan, E. Y. Nazaretyan, A. S. Boyajyan   +4 more
doaj   +3 more sources

Alternative Complement Pathway Inhibition by Lampalizumab

Ophthalmology Science, 2023
Purpose: Lampalizumab, an antigen-binding fragment of a humanized monoclonal antibody directed against complement factor D (CFD), is designed to treat geographic atrophy (GA) secondary to age-related macular degeneration.
Rose Edmonds, MS, Verena Steffen, MSc, Lee A. Honigberg, PhD, Michael C. Chang, PhD   +3 more
doaj   +2 more sources

Complement alternative pathway activation in human nonalcoholic steatohepatitis. [PDF]

PLoS ONE, 2014
The innate immune system plays a major role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Recently we reported complement activation in human NASH.
Filip M Segers, Froukje J Verdam, Charlotte de Jonge, Bas Boonen, Ann Driessen, Ronit Shiri-Sverdlov, Nicole D Bouvy, Jan Willem M Greve, Wim A Buurman, Sander S Rensen   +9 more
doaj   +5 more sources

Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi [PDF]

, 2017
Complement is an important part of innate immunity. The alternative pathway of complement is activated when the main opsonin, C3b coats non-protected surfaces leading to opsonisation, phagocytosis and cell lysis.
A Bhattacharjee, A Richards, Adrian Goldman, AJ McCoy, AO Edwards, B Nagar, BS Blaum, C Hammerschmidt, C Siegel, CA Diebolder, Catherine A. Brissette, D Weismann, DE Isenman, DL Gordon, E Goicoechea de Jorge, E Krissinel, EM Adams, J Esparza-Gordillo, J Hellwage, J Pietikäinen, J Wu, JD Lambris, JH Williams Jr., JJ Caesar, JJ Caesar, JM van den Elsen, JM Weiler, K Brangulis, K Haupt, K Whaley, Kornelia M. Mikula, M Jozsi, M Jozsi, M Jozsi, MC Carroll, MD Winn, MJ Lehtinen, MJ Lehtinen, MJ Walport, MK Pangburn, P Emsley, P Kraiczy, PD Adams, PF Zipfel, PW Dempsey, RB Sim, Robert Kolodziejczyk, S Breitner-Ruddock, S Hyvärinen, S Kühn, S Ram, T Kajander, T Meri, T. Sakari Jokiranta, Taru Meri, Tommi Kotila, TS Jokiranta, Vincent L. G. Postis, W Kabsch   +58 more
core   +15 more sources

Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway

Frontiers in Immunology, 2021
The complement system is central to first-line defense against invading pathogens. However, excessive complement activation and/or the loss of complement regulation contributes to the development of autoimmune diseases, systemic inflammation, and ...
Jonathan Barratt, Jonathan Barratt, Ilene Weitz   +2 more
doaj   +1 more source

Complement factor D is linked to platelet activation in human and rodent sepsis

Intensive Care Medicine Experimental, 2021
Background The complement factor D (CFD) exerts a regulatory role during infection. However, its physiological function in coagulopathy and its impact on the course of an infection remains unclear. Materials Wild-type and CFD-deficient mice (n = 91) were
O. Sommerfeld, K. Dahlke, M. Sossdorf, R. A. Claus, A. Scherag, M. Bauer, F. Bloos   +6 more
doaj   +1 more source

The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases

Frontiers in Immunology, 2021
The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu, Shaopeiwen Luo, Stefanie A. Ma, Priyanka Saminathan, Herman Li, Jenny M. Gunnersen, Harris A. Gelbard, Jennetta W. Hammond   +7 more
doaj   +1 more source

Alternative Complement Pathway Inhibition Abrogates Pneumococcal Opsonophagocytosis in Vaccine-Naïve, but Not in Vaccinated Individuals

Frontiers in Immunology, 2021
To assess the relative contribution of opsonisation by antibodies, classical and alternative complement pathways to pneumococcal phagocytosis, we analyzed killing of pneumococci by human blood leukocytes collected from vaccine-naïve and PCV13-vaccinated ...
Lukas Muri, Lukas Muri, Emma Ispasanie, Emma Ispasanie, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke, Gerd Pluschke   +10 more
doaj   +1 more source

The alternative complement pathway revisited [PDF]

Journal of Cellular and Molecular Medicine, 2008
Introduction Methods to study and modify the alternative pathway Influence of AP amplification on the effect of specific activation of the other initial pathways Properdin Influence of AP in deficiency states Complement in sepsis Concluding remarks AbstractAlternative pathway amplification plays a major role for the final effect of initial specific ...
Harboe, Morten, Mollnes, Tom Eirik
openaire   +2 more sources