Results 1 to 10 of about 125,164 (165)
Complement-Mediated Kidney Diseases: Role of Alternative Pathway in Glomerular Inflammation [PDF]
Kidney International ReportsComplement-mediated kidney diseases (CMKDs) comprise a diverse group of rare disorders characterized by the activation of the complement system, leading to glomerular inflammation, kidney injury, and in some cases, kidney failure.
Jonathan Barratt +4 more
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DYSFUNCTION OF COMPLEMENT SYSTEM IN FAMILIAL MEDITERRANEAN FEVER
Медицинская иммунология, 2014 . During attacks of familial mediterranean fever (FMF), multiple systemic events are triggered, most of which promote autoinflammatory reactions. A molecular pattern of immune abnormalities in FMF is yet unclear.
G. M. Mkrtchyan +4 more
doaj +3 more sources
Alternative Complement Pathway Inhibition by Lampalizumab
Ophthalmology Science, 2023 Purpose: Lampalizumab, an antigen-binding fragment of a humanized monoclonal antibody directed against complement factor D (CFD), is designed to treat geographic atrophy (GA) secondary to age-related macular degeneration.
Rose Edmonds, MS +3 more
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Complement alternative pathway activation in human nonalcoholic steatohepatitis. [PDF]
PLoS ONE, 2014 The innate immune system plays a major role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Recently we reported complement activation in human NASH.
Filip M Segers +9 more
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Expression of Properdin, the positive regulator of the Complement Alternative Pathway, at the fetal-maternal interface in Preeclampsia [PDF]
Frontiers in ImmunologyIntroductionAberrant complement activation can cause damage to newly formed fetal-derived structures and excessive inflammatory response at the feto-maternal interface, contributing to pregnancy-related complications, including preeclampsia (PE), which ...
Hadida Yasmin +16 more
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Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway
Frontiers in Immunology, 2021 The complement system is central to first-line defense against invading pathogens. However, excessive complement activation and/or the loss of complement regulation contributes to the development of autoimmune diseases, systemic inflammation, and ...
Jonathan Barratt +2 more
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Complement factor D is linked to platelet activation in human and rodent sepsis
Intensive Care Medicine Experimental, 2021 Background The complement factor D (CFD) exerts a regulatory role during infection. However, its physiological function in coagulopathy and its impact on the course of an infection remains unclear. Materials Wild-type and CFD-deficient mice (n = 91) were
O. Sommerfeld +6 more
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Frontiers in Immunology, 2021 The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu +7 more
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The alternative complement pathway revisited [PDF]
Journal of Cellular and Molecular Medicine, 2008 Introduction Methods to study and modify the alternative pathway Influence of AP amplification on the effect of specific activation of the other initial pathways Properdin Influence of AP in deficiency states Complement in sepsis Concluding remarks AbstractAlternative pathway amplification plays a major role for the final effect of initial specific ...
Harboe, Morten, Mollnes, Tom Eirik
openaire +2 more sources
Frontiers in Immunology, 2021 BackgroundThe SARS-CoV-2 infection triggers excessive immune response resulting in increased levels of pro-inflammatory cytokines, endothelial injury, and intravascular coagulopathy.
Federica Defendi +21 more
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