Results 11 to 20 of about 125,164 (165)
Frontiers in Immunology, 2021 To assess the relative contribution of opsonisation by antibodies, classical and alternative complement pathways to pneumococcal phagocytosis, we analyzed killing of pneumococci by human blood leukocytes collected from vaccine-naïve and PCV13-vaccinated ...
Lukas Muri +10 more
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The Complement System and ANCA Associated Vasculitis in the Era of Anti-Complement Drugs
Frontiers in Immunology, 2022 ANCA (anti-neutrophil cytoplasmic antibody)-associated vasculitis (AAV) is the condition in which ANCA, as an autoantibody, is associated with the pathogenesis of vasculitis in small blood vessels, mainly in the ear, nose, throat, kidney, lung, and ...
Yasutaka Kimoto, Takahiko Horiuchi
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Diagnosis of complement alternative pathway disorders [PDF]
Kidney International, 2016 Kidney diseases resulting from abnormal control of the complement alternative pathway include atypical hemolytic uremic syndrome, C3 glomerulonephritis, and dense-deposit disease, as well as atypical postinfectious glomerulonephritis. Although clinically diverse, they all result from loss of surface or fluid-phase complement control, caused by acquired
Angioi A +8 more
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Dengue virus and the complement alternative pathway [PDF]
FEBS Letters, 2020 Dengue disease is an inflammatory‐driven pathology, and complement overactivation is linked to disease severity and vascular leakage. Additionally, dysregulation of complement alternative pathway (AP) components has been described, such as upregulation of complement factor D and downregulation of complement factor H (FH), which activate and inhibit the
Jillian M. Carr +4 more
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Frontiers in Immunology, 2018 The complement system has moved into the focus of drug development efforts in the last decade, since its inappropriate or uncontrolled activation has been recognized in many diseases.
József Dobó +2 more
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Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis [PDF]
Kidney Research and Clinical Practice, 2023 Background Alternative complement pathway dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and ...
Jiwon Ryu +14 more
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Quantitative Modeling of the Alternative Pathway of the Complement System. [PDF]
PLoS ONE, 2016 The complement system is an integral part of innate immunity that detects and eliminates invading pathogens through a cascade of reactions. The destructive effects of the complement activation on host cells are inhibited through versatile regulators that
Nehemiah Zewde +3 more
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Mathematical Modelling of Alternative Pathway of Complement System [PDF]
Bulletin of Mathematical Biology, 2020 AbstractThe complement system (CS) is an integral part of innate immunity and can be activated via three different pathways. The alternative pathway (AP) has a central role in the function of the CS. The AP of complement system is implicated in several human disease pathologies.
Suruchi Bakshi +10 more
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Frontiers in Immunology, 2015 The complement system is a major constituent of the innate immune system. It not only bridges innate and adaptive arms of the immune system but also links the immune system with the coagulation system.
Hany Ibrahim Kenawy +2 more
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Frontiers in Immunology, 2022 ObjectiveThe pathogenesis of thrombotic microangiopathy (TMA) in lupus nephritis (LN) remains complicated. This study aimed to detect the deposition of complement lectin pathway (LP) and alternative pathway (AP) components in renal tissues, then evaluate
Binshan Zhang, Guolan Xing
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