Results 11 to 20 of about 471,706 (342)

The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. [PDF]

PLoS Pathogens, 2012
The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Youssif M Ali, Nicholas J Lynch, Kashif S Haleem, Teizo Fujita, Yuichi Endo, Soren Hansen, Uffe Holmskov, Kazue Takahashi, Gregory L Stahl, Thomas Dudler, Umakhanth V Girija, Russell Wallis, Aras Kadioglu, Cordula M Stover, Peter W Andrew, Wilhelm J Schwaeble   +15 more
doaj   +15 more sources

Properdin and Factor H: Opposing Players on the Alternative Complement Pathway “See-Saw” [PDF]

Frontiers in Immunology, 2013
Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilizing the C3bBb complex, whereas factor H downregulates the pathway by ...
Lubna Kouser, Munirah Abdul-Aziz, Annapurna Nayak, C. Stover, Robert B Sim, U. Kishore   +5 more
semanticscholar   +3 more sources

Low molecular weight polysialic acid binds to properdin and reduces the activity of the alternative complement pathway [PDF]

Scientific Reports, 2022
Sialic acids as the terminal caps of the cellular glycocalyx play an essential role in self-recognition and were shown to modulate complement processes via interaction between α2,3-linked sialic acids and complement factor H. Previously, it was suggested
Anahita Shahraz, Yuchen Lin, Joshua Mbroh, Jonas Winkler, Huan Liao, Marie Lackmann, Annemarie Bungartz, Peter F. Zipfel, Christine Skerka, Harald Neumann   +9 more
doaj   +2 more sources

Alternative Pathway Dysregulation and the Conundrum of Complement Activation by IgG4 Immune Complexes in Membranous Nephropathy [PDF]

Frontiers in Immunology, 2016
Membranous nephropathy (MN), a major cause of nephrotic syndrome, is a non-inflammatory immune kidney disease mediated by IgG antibodies that form glomerular subepithelial immune complexes.
D. Borza
semanticscholar   +3 more sources

Ecotin, a microbial inhibitor of serine proteases, blocks multiple complement dependent and independent microbicidal activities of human serum. [PDF]

PLoS Pathogens, 2019
Ecotin is a serine protease inhibitor produced by hundreds of microbial species, including pathogens. Here we show, that ecotin orthologs from Escherichia coli, Yersinia pestis, Pseudomonas aeruginosa and Leishmania major are potent inhibitors of MASP-1 ...
Zoltán Attila Nagy, Dávid Szakács, Eszter Boros, Dávid Héja, Eszter Vígh, Noémi Sándor, Mihály Józsi, Gábor Oroszlán, József Dobó, Péter Gál, Gábor Pál   +10 more
doaj   +3 more sources

The alternative complement pathway revisited [PDF]

Journal of Cellular and Molecular Medicine, 2008
Introduction Methods to study and modify the alternative pathway Influence of AP amplification on the effect of specific activation of the other initial pathways Properdin Influence of AP in deficiency states Complement in sepsis Concluding remarks AbstractAlternative pathway amplification plays a major role for the final effect of initial specific ...
Tom Eirik Mollnes, Morten Harboe
openaire   +2 more sources

Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi [PDF]

, 2017
Complement is an important part of innate immunity. The alternative pathway of complement is activated when the main opsonin, C3b coats non-protected surfaces leading to opsonisation, phagocytosis and cell lysis.
A Bhattacharjee, A Richards, Adrian Goldman, AJ McCoy, AO Edwards, B Nagar, BS Blaum, C Hammerschmidt, C Siegel, CA Diebolder, Catherine A. Brissette, D Weismann, DE Isenman, DL Gordon, E Goicoechea de Jorge, E Krissinel, EM Adams, J Esparza-Gordillo, J Hellwage, J Pietikäinen, J Wu, JD Lambris, JH Williams Jr., JJ Caesar, JJ Caesar, JM van den Elsen, JM Weiler, K Brangulis, K Haupt, K Whaley, Kornelia M. Mikula, M Jozsi, M Jozsi, M Jozsi, MC Carroll, MD Winn, MJ Lehtinen, MJ Lehtinen, MJ Walport, MK Pangburn, P Emsley, P Kraiczy, PD Adams, PF Zipfel, PW Dempsey, RB Sim, Robert Kolodziejczyk, S Breitner-Ruddock, S Hyvärinen, S Kühn, S Ram, T Kajander, T Meri, T. Sakari Jokiranta, Taru Meri, Tommi Kotila, TS Jokiranta, Vincent L. G. Postis, W Kabsch   +58 more
core   +13 more sources

The complement alternative pathway in paroxysmal nocturnal hemoglobinuria: From a pathogenic mechanism to a therapeutic target

Immunological Reviews, 2022
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal, not malignant, hematological disease characterized by intravascular hemolysis, thrombophilia and bone marrow failure.
A. Risitano, Camilla Frieri, E. Urciuoli, L. Marano   +3 more
semanticscholar   +1 more source

Complement factor D is linked to platelet activation in human and rodent sepsis

Intensive Care Medicine Experimental, 2021
Background The complement factor D (CFD) exerts a regulatory role during infection. However, its physiological function in coagulopathy and its impact on the course of an infection remains unclear. Materials Wild-type and CFD-deficient mice (n = 91) were
O. Sommerfeld, K. Dahlke, M. Sossdorf, R. A. Claus, A. Scherag, M. Bauer, F. Bloos   +6 more
doaj   +1 more source

The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases

Frontiers in Immunology, 2021
The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu, Shaopeiwen Luo, Stefanie A. Ma, Priyanka Saminathan, Herman Li, Jenny M. Gunnersen, Harris A. Gelbard, Jennetta W. Hammond   +7 more
doaj   +1 more source