Results 21 to 30 of about 24,198,541 (380)
Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics
Pharmacological Reviews, 2021 The complement system was discovered at the end of the 19th century as a heat-labile plasma component that “complemented” the antibodies in killing microbes, hence the name “complement.” Complement is also part of the innate immune system, protecting the
P. Garred, A. Tenner, T. Mollnes
semanticscholar +1 more source
The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host’s Complement System
Biomolecules, 2022 The complement system exerts crucial functions both in innate immune responses and adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen invasions including protozoan parasites.
Sajad Rashidi +5 more
doaj +1 more source
Tipping the balance: intricate roles of the complement system in disease and therapy
Seminars in Immunopathology, 2021 The ability of the complement system to rapidly and broadly react to microbial intruders, apoptotic cells and other threats by inducing forceful elimination responses is indispensable for its role as host defense and surveillance system.
R. Pouw, Daniel Ricklin
semanticscholar +1 more source
The complement system in COVID-19: friend and foe?
JCI Insight, 2020 COVID-19, the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in a global pandemic and a disruptive health crisis. COVID-19-related morbidity and mortality has been attributed to an exaggerated immune response.
A. Java +6 more
semanticscholar +1 more source
Complement System in Alzheimer’s Disease
International Journal of Molecular Sciences, 2021 Alzheimer’s disease is a type of dementia characterized by problems with short-term memory, cognition, and difficulties with activities of daily living. It is a progressive, neurodegenerative disorder.
A. Shah, U. Kishore, A. Shastri
semanticscholar +1 more source
Proprotein Convertases and the Complement System
Frontiers in Immunology, 2022 Proteins destined for secretion - after removal of the signal sequence - often undergo further proteolytic processing by proprotein convertases (PCs).
József Dobó +3 more
doaj +1 more source
Antimicrobial Peptide Arenicin-1 Derivative Ar-1-(C/A) as Complement System Modulator
Marine Drugs, 2020 Antimicrobial peptides (AMPs) are not only cytotoxic towards host pathogens or cancer cells but also are able to act as immunomodulators. It was shown that some human and non-human AMPs can interact with complement proteins and thereby modulate ...
Ilia A. Krenev +11 more
doaj +1 more source
Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target
Frontiers in Immunology, 2021 Endometriosis (EM) is a chronic disease characterized by the presence and proliferation of functional endometrial glands and stroma outside the uterine cavity.
C. Agostinis +7 more
semanticscholar +1 more source
Respiratory Research, 2022 Background The efficacy and safety of complement inhibition in COVID-19 patients is unclear. Methods A multicenter randomized controlled, open-label trial.
Elisabeth De Leeuw +27 more
doaj +1 more source
Aberrant Complement System Activation in Neurological Disorders
International Journal of Molecular Sciences, 2021 The complement system is an assembly of proteins that collectively participate in the functions of the healthy and diseased brain. The complement system plays an important role in the maintenance of uninjured (healthy) brain homeostasis, contributing to ...
Karolina Ziabska +4 more
semanticscholar +1 more source