Results 21 to 30 of about 1,195,438 (288)

Acidosis activates complement system in vitro

Mediators of Inflammation, 1998
We investigated the in vitro effect of different form s of acidosis (pH 7.0) on the formation of anaphylatoxins C3a and C5a. Metabolic acidosis due to addition of hydrochloric acid (10 μ mol/ml blood) or lactic acid (5.5 μ mol/ml) to heparin blood (N=12)
Michael Emeis, Josef Sonntag, Carsten Willam, Evelyn Strauss, Matthias M. Walka, Michael Obladen   +5 more
doaj   +1 more source

Francisella tularensis Confronts the Complement System

Frontiers in Cellular and Infection Microbiology, 2017
Francisella tularensis has developed a number of effective evasion strategies to counteract host immune defenses, not the least of which is its ability to interact with the complement system to its own advantage.
Susan R. Brock, Michael J. Parmely
doaj   +1 more source

Complement Evasion: An Effective Strategy That Parasites Utilize to Survive in the Host

Frontiers in Microbiology, 2019
Parasitic infections induce host immune responses that eliminate the invading parasites. However, parasites have evolved to develop many strategies to evade host immune attacks and survive in a hostile environment. The complement system acts as the first
Shuai Shao, Ximeng Sun, Yi Chen, Bin Zhan, Xinping Zhu   +4 more
doaj   +1 more source

Pitfalls in complement analysis: A systematic literature review of assessing complement activation

Frontiers in Immunology, 2022
BackgroundThe complement system is an essential component of our innate defense and plays a vital role in the pathogenesis of many diseases. Assessment of complement activation is critical in monitoring both disease progression and response to therapy ...
Ricardo J. M. G. E. Brandwijk, Marloes A. H. M. Michels, Mara van Rossum, Aline H. de Nooijer, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Wieke C. C. de Bruin, Erik J. M. Toonen   +8 more
doaj   +1 more source

Genetic bases of C7 deficiency: systematic review and report of a novel deletion determining functional hemizygosity

Frontiers in Immunology, 2023
Primary complement system (C) deficiencies are rare but notably associated with an increased risk of infections, autoimmunity, or immune disorders.
Andrea Balduit, Anna Monica Bianco, Alessandro Mangogna, Anna Maria Zicari, Lucia Leonardi, Bianca Laura Cinicola, Bianca Laura Cinicola, Martina Capponi, Alberto Tommasini, Alberto Tommasini, Chiara Agostinis, Adamo Pio d’Adamo, Adamo Pio d’Adamo, Roberta Bulla   +13 more
doaj   +1 more source

Schur complement based preconditioners for twofold and block tridiagonal saddle point problems [PDF]

arXiv, 2021
In this paper, we consider using Schur complements to design preconditioners for twofold and block tridiagonal saddle point problems. One type of the preconditioners are based on the nested (or recursive) Schur complement, the other is based on an additive type Schur complement after permuting the original saddle point systems.
arxiv  

The complement system in glioblastoma multiforme

Acta Neuropathologica Communications, 2018
The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute.
T. A. M. Bouwens van der Vlis, J. M. Kros, D. A. M. Mustafa, R. T. A. van Wijck, L. Ackermans, P. M. van Hagen, P. J. van der Spek   +6 more
doaj   +1 more source

Dysregulation of Complement Activation and Placental Dysfunction: A Potential Target to Treat Preeclampsia?

Frontiers in Immunology, 2020
Preeclampsia is one of the leading causes of maternal and neonatal mortality and morbidity worldwide, affecting 2–8% of all pregnancies. Studies suggest a link between complement activation and preeclampsia.
E. Pierik, Jelmer R. Prins, Harry van Goor, Gustaaf A. Dekker, Mohamed R. Daha, Marc A. J. Seelen, Sicco A. Scherjon   +6 more
doaj   +1 more source

Interaction Between the Complement System and Infectious Agents – A Potential Mechanistic Link to Neurodegeneration and Dementia

Frontiers in Cellular Neuroscience, 2021
As part of the innate immune system, complement plays a critical role in the elimination of pathogens and mobilization of cellular immune responses. In the central nervous system (CNS), many complement proteins are locally produced and regulate nervous ...
Noriko Shinjyo, Noriko Shinjyo, Wataru Kagaya, Marcela Pekna, Marcela Pekna   +4 more
doaj   +1 more source

Therapeutic Lessons to be Learned From the Role of Complement Regulators as Double-Edged Sword in Health and Disease

Frontiers in Immunology, 2020
The complement system is an important part of the innate immune system, providing a strong defense against pathogens and removing apoptotic cells and immune complexes.
Esther C. W. de Boer, Esther C. W. de Boer, Anouk G. van Mourik, Ilse Jongerius, Ilse Jongerius   +4 more
doaj   +1 more source