Results 21 to 30 of about 24,757,633 (403)
Streptococcus pneumoniae interactions with the complement system
Frontiers in Cellular and Infection Microbiology, 2022 Host innate and adaptive immunity to infection with Streptococcus pneumoniae is critically dependent on the complement system, demonstrated by the high incidence of invasive S.
Eliza Gil +2 more
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Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics
Pharmacological Reviews, 2021 The complement system was discovered at the end of the 19th century as a heat-labile plasma component that “complemented” the antibodies in killing microbes, hence the name “complement.” Complement is also part of the innate immune system, protecting the
P. Garred, A. Tenner, T. Mollnes
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Tipping the balance: intricate roles of the complement system in disease and therapy
Seminars in Immunopathology, 2021 The ability of the complement system to rapidly and broadly react to microbial intruders, apoptotic cells and other threats by inducing forceful elimination responses is indispensable for its role as host defense and surveillance system.
R. Pouw, Daniel Ricklin
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The complement system in COVID-19: friend and foe?
JCI Insight, 2020 COVID-19, the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in a global pandemic and a disruptive health crisis. COVID-19-related morbidity and mortality has been attributed to an exaggerated immune response.
A. Java +6 more
semanticscholar +1 more source
Complement System in Alzheimer’s Disease
International Journal of Molecular Sciences, 2021 Alzheimer’s disease is a type of dementia characterized by problems with short-term memory, cognition, and difficulties with activities of daily living. It is a progressive, neurodegenerative disorder.
A. Shah, U. Kishore, A. Shastri
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Antimicrobial Peptide Arenicin-1 Derivative Ar-1-(C/A) as Complement System Modulator
Marine Drugs, 2020 Antimicrobial peptides (AMPs) are not only cytotoxic towards host pathogens or cancer cells but also are able to act as immunomodulators. It was shown that some human and non-human AMPs can interact with complement proteins and thereby modulate ...
Ilia A. Krenev +11 more
doaj +1 more source
Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target
Frontiers in Immunology, 2021 Endometriosis (EM) is a chronic disease characterized by the presence and proliferation of functional endometrial glands and stroma outside the uterine cavity.
C. Agostinis +7 more
semanticscholar +1 more source
Aberrant Complement System Activation in Neurological Disorders
International Journal of Molecular Sciences, 2021 The complement system is an assembly of proteins that collectively participate in the functions of the healthy and diseased brain. The complement system plays an important role in the maintenance of uninjured (healthy) brain homeostasis, contributing to ...
Karolina Ziabska +4 more
semanticscholar +1 more source
The complement system and autoimmune diseases
Chronic Diseases and Translational Medicine, 2022 The complement system plays a key role in the pathogenesis of autoimmune diseases, which usually injures the kidney. More and more studies have shown the pathogenic role and indicated that abnormal activation of the complement system was highly involved ...
Changhao Jia, Ying Tan, Minghui Zhao
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Complement System and Potential Therapeutics in Age-Related Macular Degeneration
International Journal of Molecular Sciences, 2021 Age-related macular degeneration (AMD) is a complex multifactorial disease characterized in its late form by neovascularization (wet type) or geographic atrophy of the retinal pigment epithelium cell layer (dry type).
Young Gun Park, Y. Park, In-Beom Kim
semanticscholar +1 more source