Results 31 to 40 of about 572,210 (231)
New insights into the immune functions of podocytes: the role of complement
Molecular and Cellular Pediatrics, 2023 Podocytes are differentiated epithelial cells which play an essential role to ensure a normal function of the glomerular filtration barrier (GFB). In addition to their adhesive properties in maintaining the integrity of the filtration barrier, they have ...
Valentina Bruno +3 more
doaj +1 more source
Acidosis activates complement system in vitro
Mediators of Inflammation, 1998 We investigated the in vitro effect of different form s of acidosis (pH 7.0) on the formation of anaphylatoxins C3a and C5a. Metabolic acidosis due to addition of hydrochloric acid (10 μ mol/ml blood) or lactic acid (5.5 μ mol/ml) to heparin blood (N=12)
Michael Emeis +5 more
doaj +1 more source
Frontiers in Immunology, 2018 The complement system has moved into the focus of drug development efforts in the last decade, since its inappropriate or uncontrolled activation has been recognized in many diseases.
József Dobó +2 more
doaj +1 more source
Combined anti-C1-INH and radiotherapy against glioblastoma
BMC Cancer, 2023 Background A more effective immune response against glioblastoma is needed in order to achieve better tumor control. Radiotherapy can induce anti-tumor mediated immune reactions, in addition to its dose response effects.
Emma Liljedahl +7 more
doaj +1 more source
Complement System in Alzheimer’s Disease [PDF]
International Journal of Molecular Sciences, 2021 Alzheimer’s disease is a type of dementia characterized by problems with short-term memory, cognition, and difficulties with activities of daily living. It is a progressive, neurodegenerative disorder. The complement system is an ancient part of the innate immune system and comprises of more than thirty serum and membrane-bound proteins.
Akash Shah +2 more
openaire +4 more sources
Pitfalls in complement analysis: A systematic literature review of assessing complement activation
Frontiers in Immunology, 2022 BackgroundThe complement system is an essential component of our innate defense and plays a vital role in the pathogenesis of many diseases. Assessment of complement activation is critical in monitoring both disease progression and response to therapy ...
Ricardo J. M. G. E. Brandwijk +8 more
doaj +1 more source
The complement system in glioblastoma multiforme
Acta Neuropathologica Communications, 2018 The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute.
T. A. M. Bouwens van der Vlis +6 more
doaj +1 more source
Frontiers in Immunology, 2023 Primary complement system (C) deficiencies are rare but notably associated with an increased risk of infections, autoimmunity, or immune disorders.
Andrea Balduit +13 more
doaj +1 more source
Complement Evasion: An Effective Strategy That Parasites Utilize to Survive in the Host
Frontiers in Microbiology, 2019 Parasitic infections induce host immune responses that eliminate the invading parasites. However, parasites have evolved to develop many strategies to evade host immune attacks and survive in a hostile environment. The complement system acts as the first
Shuai Shao +4 more
doaj +1 more source
Frontiers in Immunology, 2020 Preeclampsia is one of the leading causes of maternal and neonatal mortality and morbidity worldwide, affecting 2–8% of all pregnancies. Studies suggest a link between complement activation and preeclampsia.
E. Pierik +6 more
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