Results 31 to 40 of about 24,198,541 (380)
The complement system and autoimmune diseases
Chronic Diseases and Translational Medicine, 2022 The complement system plays a key role in the pathogenesis of autoimmune diseases, which usually injures the kidney. More and more studies have shown the pathogenic role and indicated that abnormal activation of the complement system was highly involved ...
Changhao Jia, Ying Tan, Minghui Zhao
doaj +1 more source
Complement System and Potential Therapeutics in Age-Related Macular Degeneration
International Journal of Molecular Sciences, 2021 Age-related macular degeneration (AMD) is a complex multifactorial disease characterized in its late form by neovascularization (wet type) or geographic atrophy of the retinal pigment epithelium cell layer (dry type).
Young Gun Park, Y. Park, In-Beom Kim
semanticscholar +1 more source
Detection and characterisation of Complement protein activity in bovine milk by bactericidal sequestration assay [PDF]
, 2015 Susan Maye is in receipt of a Teagasc Walsh Fellowship. Financial support by the Department of Agriculture, Food and the Marine is gratefully acknowledged.Copyright © Proprietors of Journal of Dairy Research 2015 (Institute of Food Research and the ...
Fitzgerald, Gerald F +3 more
core +1 more source
Complement activation and protein adsorption by carbon nanotubes [PDF]
, 2006 As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel +5 more
core +2 more sources
Cell and Tissue Research, 2010 The complement system consists of a tightly regulated network of proteins that play an important role in host defense and inflammation. Complement activation results in opsonization of pathogens and their removal by phagocytes, as well as cell lysis.
Peter A. Ward, J. Vidya Sarma
openaire +4 more sources
Complement System Part I – Molecular Mechanisms of Activation and Regulation
Frontiers in Immunology, 2015 Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger ...
N. Merle +3 more
semanticscholar +1 more source
The good, the bad, and the opportunities of the complement system in neurodegenerative disease
Journal of Neuroinflammation, 2020 The complement cascade is a critical effector mechanism of the innate immune system that contributes to the rapid clearance of pathogens and dead or dying cells, as well as contributing to the extent and limit of the inflammatory immune response.
Nicole D. Schartz, A. Tenner
semanticscholar +1 more source
The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]
, 2018 The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J +4 more
core +1 more source
Quantitative multiplex profiling of the complement system to diagnose complement‐mediated diseases
Clinical & Translational Immunology, 2020 Objectives Complement deficiencies are difficult to diagnose because of the variability of symptoms and the complexity of the diagnostic process. Here, we applied a novel ‘complementomics’ approach to study the impact of various complement deficiencies ...
Esther Willems +23 more
doaj +1 more source
Complement System in Brain Architecture and Neurodevelopmental Disorders
Frontiers in Neuroscience, 2020 Current evidence indicates that certain immune molecules such as components of the complement system are directly involved in neurobiological processes related to brain development, including neurogenesis, neuronal migration, synaptic remodeling, and ...
J. Magdalon +5 more
semanticscholar +1 more source