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Acta Tropica, 2021
Escaping the complement system is an important step in the establishment of infections. Some pathogens have acquired the ability to inactivate the complement system to ensure successful infection. This has been observed in parasites from the genus Leishmania, which inactivate C3b molecules deposited on their surface through the membrane protease GP63 ...
Adalberto Alves Pereira Filho +9 more
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Escaping the complement system is an important step in the establishment of infections. Some pathogens have acquired the ability to inactivate the complement system to ensure successful infection. This has been observed in parasites from the genus Leishmania, which inactivate C3b molecules deposited on their surface through the membrane protease GP63 ...
Adalberto Alves Pereira Filho +9 more
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The Journal of Immunology, 1984
Abstract A lamprey protein homologous to the third component of mammalian complement was isolated from lamprey plasma and was tentatively designated lamprey C3. Lamprey C3 is a major protein in lamprey serum with electrophoretic mobility of beta-globulin and with m.w. of 190,000.
M, Nonaka +6 more
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Abstract A lamprey protein homologous to the third component of mammalian complement was isolated from lamprey plasma and was tentatively designated lamprey C3. Lamprey C3 is a major protein in lamprey serum with electrophoretic mobility of beta-globulin and with m.w. of 190,000.
M, Nonaka +6 more
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The function of the proteins in the complement system
Trends in Biochemical Sciences, 1976Abstract The proteins which constitute the complement system are normal components in the fluid portion of blood and other fluids of man and lower animals. Activation of these proteins via two major pathways results in a number of biologically significant activities which may be beneficial or detrimental to the host.
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Protein-Protein Interaction in the α-Complementation System of β-Galactosidase
1992Publisher Summary This chapter discusses protein–protein interaction in the α-complementation system of β-galactosidase. α-complementation system in β-galactosidase system is a system of protein–protein interaction where active enzyme is formed through the association of two different polypeptide chains encoded by different lacZ alleles.
J H, Zeilstra-Ryalls, R L, Somerville
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Pregnancy-associated plasma protein-A: An inhibitor of the complement system
Placenta, 1981Pregnancy-associated plasma protein-A (PAPP-A) was purified to homogenicity from third-trimester pregnancy plasma using ion exchange chromatography and affinity chromatography on con A-Sepharose and anti-human serum-Sepharose. The elution of PAPP-A, alpha 2-macroglobulin, Cl-inhibitor and alpha 1-antitrypsin was followed by immuno-diffusion.
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Study of the interaction between monoclonal IgM proteins and the complement system
Immunochemistry, 1976Abstract The capacity to activate the complement system and to fix isolated C1 of different monoclonal IgM proteins and various fragments was studied. All the 8 different IgM proteins tested fixed isolated C1, but the dose of the IgM preparations necessary for the fixation of the 50% of the available C1 activity strongly differed from each other. The
G, Füst +4 more
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Effect of a protein-bound polysaccharide PS-K on the complement system
Research in Experimental Medicine, 1983A protein-bound polysaccharide from mycelia of Coriolus versicolor PS-K, clinically used as an immunomodulator, has been shown to restore the decreased cellular immune response and to exhibit host-mediated antitumor activity. In this experiment, PS-K was found to increase serum complement level in guinea pig and in human without malignancy, when ...
H, Kato +5 more
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Molecular Immunology, 2009
This study describes how the serum protein histidine-rich glycoprotein (HRG) affects the complement system. We show that HRG binds strongly to several complement proteins: C1q, factor H and C4b-binding protein and that it is found complexed with these proteins in human sera and synovial fluids of rheumatoid arthritis patients.
G A, Manderson +7 more
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This study describes how the serum protein histidine-rich glycoprotein (HRG) affects the complement system. We show that HRG binds strongly to several complement proteins: C1q, factor H and C4b-binding protein and that it is found complexed with these proteins in human sera and synovial fluids of rheumatoid arthritis patients.
G A, Manderson +7 more
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Complement System Genes and the Structures of the Proteins They Encode
1993The complement system plasma proteins and most of the known cell surface receptors and control proteins have now been cloned at both the cDNA and genomic levels, and chromosomal assignments are available for the majority of the genes (Table 1) (for review see Reid and Campbell 1992).
R. D. Campbell, A. J. Day
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Leishmanial protein kinases phosphorylate components of the complement system.
The EMBO Journal, 1991Externally oriented protein kinases are present on the plasma membrane of the human parasite, Leishmania. Since activation of complement plays an important role in the survival of these parasites, we examined the ability of protein kinases from Leishmania major to phosphorylate components of the human complement system. The leishmanial protein kinase-1
T, Hermoso +4 more
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