Results 91 to 100 of about 11,073 (199)

Functional Analysis of Subunit e of the F\u3csub\u3e1\u3c/sub\u3eF\u3csub\u3eo\u3c/sub\u3e-ATP Synthase of the Yeast \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e: Importance of the N-Terminal Membrane Anchor Region [PDF]

, 2005
Mitochondrial F1Fo-ATP synthase complexes do not exist as physically independent entities but rather form dimeric and possibly oligomeric complexes in the inner mitochondrial membrane.
Brunner, Susanne, Dolan, Brigid M., Dunn, Cory D., Everard-Gigot, Valerie, Jensen, Robert E., Stuart, Rosemary A.   +5 more
core   +1 more source

Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses [PDF]

, 2006
Synaptic vesicle (SV) exocytosis mediating neurotransmitter release occurs spontaneously at low intraterminal calcium concentrations and is stimulated by a rise in intracellular calcium.
A. Scheuber, Blagoveshchenskaya, Dell'Angelica, Fa  ndez, G. Raposo, Goda, Guti  rrez, Hayashi, J.-C. Poncer, Kamiya, Kantheti, L. Danglot, Li, Lopantsev, Musleh, Muzerelle, R. Rudge, Rizzoli, Rosenmund, Sakaba, Schoch, Sj  str  m, Stobrawa, Stoppini, Sudhof, Sugita, Sugita, T. Binz, T. Galli, Takei, Vogt, Woodhall, Xu   +32 more
core   +6 more sources

Genomic Landscape of High‐Altitude Adaptation in East African Mountain Honey Bees (Apis mellifera)

Ecology and Evolution, Volume 15, Issue 8, August 2025.
Highland and lowland honey bees in East Africa exhibit distinct phenotypes despite low overall genetic differentiation. To investigate this further, we sampled honey bees from a mountain system in Uganda (red circle) and compared them with samples from Kenya.
Marco Mazzoni, Florian Loidolt, Sonja Kersten, Deborah Ruth Amulen, Patrick Vudriko, Philipp Meyer, Victor Sebastian Scharnhorst, Ricarda Scheiner, Martin Hasselmann   +8 more
wiley   +1 more source

A role of complexin–lipid interactions in membrane fusion [PDF]

FEBS Letters, 2009
Complexins (Cpxs) and synaptotagmins regulate calcium‐dependent exocytosis. A central helix in Cpx confers specific binding to the soluble N‐ethylmaleimide‐sensitive factor‐attachment protein receptor (SNARE) fusion machinery. An accessory helix in the amino‐terminal region inhibits membrane fusion by blocking SNAREpin zippering.
Seiler, Florian, Malsam, Jörg, Krause, Jean Michel, Söllner, Thomas H.   +3 more
openaire   +2 more sources

Tensor-based morphometry and stereology reveal brain pathology in the complexin1 knockout mouse. [PDF]

, 2012
Complexins (Cplxs) are small, soluble, regulatory proteins that bind reversibly to the SNARE complex and modulate synaptic vesicle release. Cplx1 knockout mice (Cplx1(-/-)) have the earliest known onset of ataxia seen in a mouse model, although hitherto ...
Kielar, Catherine, Morton, A Jennifer, Navarro Negredo, Paloma, Sawiak, Stephen J, Tse, Desmond HY   +4 more
core   +5 more sources

Signatures of selection detected from whole‐genome sequencing indicate that the small body size in dwarf rabbit breeds is caused by polygenic effects with a few major loci

Animal Genetics, Volume 56, Issue 4, August 2025.
Abstract Early genetic studies have suggested that body size in rabbits can be considered a quantitative trait. Several rabbit breeds can be distinguished based on body size, including a few dwarf breeds differentiated by other morphological characteristics.
Samuele Bovo, Miguel Carneiro, Anisa Ribani, Matteo Bolner, Valeria Taurisano, Giuseppina Schiavo, Michele Schiavitto, Francesca Bertolini, Luca Fontanesi   +8 more
wiley   +1 more source

Synaptic Vesicle Recycling at the Developing Presynapse

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
During presynaptic development, the coupling between calcium influx and synaptic vesicles (SVs) tightens with maturity, transitioning from microdomain to nanodomain. In immature neurons, spontaneous SV exocytosis is the dominant SV fusion mode, whereas SV fusion is mostly evoked by action potential firing in mature presynapses.
Nawon Kim, Michael A. Cousin
wiley   +1 more source

The release of inhibition model reproduces kinetics and plasticity of neurotransmitter release in central synapses

Communications Biology, 2023
Calcium-evoked release of neurotransmitters from synaptic vesicles (SVs) is catalysed by SNARE proteins. The predominant view is that, at rest, complete assembly of SNARE complexes is inhibited (‘clamped’) by synaptotagmin and complexin molecules ...
Christopher A. Norman, Shyam S. Krishnakumar, Yulia Timofeeva, Kirill E. Volynski   +3 more
doaj   +1 more source

The c-terminal extension of a hybrid immunoglobulin A/G heavy chain is responsible for its Golgi-mediated sorting to the vacuole [PDF]

, 2003
We have assessed the ability of the plant secretory pathway to handle the expression of complex heterologous proteins by investigating the fate of a hybrid immunoglobulin A/G in tobacco cells.
Denecke, J. (Jurgen), Frigerio, Lorenzo, Hadlington, Jane L., Ma, Julian K.-C., Nuttall, James, Santoro, Aniello, Vitale, A. (Alessandro)   +6 more
core   +2 more sources

Genetic Inactivation of the Serotonin Transporter Dysregulates Expression of Neurotransmission Genes and Genome‐Wide DNA Methylation Levels in the Medial Prefrontal Cortex of Male Rats During Postnatal Development

Developmental Neurobiology, Volume 85, Issue 3, July 2025.
ABSTRACT Reduced expression of the serotonin transporter (5‐hydroxytryptamine transporter, 5‐HTT) in early life has been associated with a delay in postnatal brain development and endophenotypes of a variety of neuropsychiatric and neurodevelopmental disorders in adolescence and adulthood.
Yvet Kroeze, Martin Oti, Roel H. M. Cooijmans, Ellen van Beusekom, Leonie I. Kroeze, Anthonieke Middelman, Hans van Bokhoven, Sharon M. Kolk, Judith R. Homberg, Huiqing Zhou   +9 more
wiley   +1 more source