Results 111 to 120 of about 11,073 (199)
Complexins: Cytosolic proteins that regulate SNAP receptor function
Cell, 1995 A family of proteins called complexins was discovered that compete with alpha-SNAP, but not synaptotagmin, for SNAP receptor binding. Complexins I and II are highly homologous hydrophilic proteins that are tightly conserved, with 100% identity among mouse, rat, and human complexin II. They are enriched in neurons where they colocalize with syntaxin and
McMahon, Harvey T. +3 more
openaire +2 more sources
eLife, 2020 Vesicle fusion is mediated by assembly of SNARE proteins between opposing membranes. While previous work suggested an active role of SNARE transmembrane domains (TMDs) in promoting membrane merger (Dhara et al., 2016), the underlying mechanism remained ...
Madhurima Dhara +5 more
doaj +1 more source
Lacustrine mollusc radiations in the Lake Malawi Basin : experiments in a natural laboratory for evolution [PDF]
, 2012 In terminal Pliocene-early Pleistocene times, part of the Malawi Basin was occupied by paleo-lake Chiwondo. Molluscan biostratigraphy situates this freshwater lake either in the East African wet phase between 2.7-2.4 Ma or that of 2.0-1.8 Ma.
Gautier, Achilles, Van Damme, Dirk
core +3 more sources
α‐Synuclein in Parkinson's Disease: From Bench to Bedside
Medicinal Research Reviews, Volume 45, Issue 3, Page 909-946, May 2025.ABSTRACT α‐Synuclein (α‐syn), a pathological hallmark of PD, is emerging as a bridging element at the crossroads between neuro/immune‐inflammatory responses and neurodegeneration in PD. Several evidence show that pathological α‐syn accumulates in neuronal and non‐neuronal cells (i.e., neurons, microglia, macrophages, skin cells, and intestinal cells ...
Gabriele Bellini +8 more
wiley +1 more source
Plasma proteomic profiles correlate with organ dysfunction in COVID‐19 ARDS
Physiological Reports, Volume 13, Issue 7, April 2025.Abstract Severe COVID‐19 is often complicated by hypoxemic respiratory failure and acute respiratory distress syndrome (ARDS). Mechanisms governing lung injury and repair in ARDS remain poorly understood. We hypothesized that plasma proteomics may uncover protein biomarkers correlated with COVID‐19 ARDS severity. We analyzed the plasma proteome from 32
Moemen Eltobgy +8 more
wiley +1 more source
Strengthening the bond with the scientific community: FEBS Open Bio in 2025
FEBS Open Bio, Volume 15, Issue 1, Page 4-10, January 2025.FEBS Open Bio remains dedicated to serving the scientific community by ensuring rapid publication of rigorous science and pioneering initiatives to support researchers. In this editorial, we reflect on a year of achievements, and look forward to the new developments planned for 2025.
Sara Fuentes, Miguel A. De la Rosa
wiley +1 more source
Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
Nature Communications, 2019 The molecular identity of the clamp that arrests the fusion machinery such that synaptic vesicles are docked and primed to release neurotransmitters remains controversial.
Nicholas A. Courtney +3 more
doaj +1 more source
The Biochemical and Genetic Odyssey to the Function of a Nicastrin-Like Protein [PDF]
, 2004 gamma-Secretase is a high-molecular-weight protein complex required for the proteolytic processing of various transmembrane proteins including the Alzheimer's disease-associated amyloid precursor protein and the signaling receptor Notch. One of the gamma-
Haass, Christian, Haffner, Christof
core +1 more source
Islet Complexins are Complex [PDF]
Biophysical Journal, 2020 Michael R. DiGruccio +3 more
openaire +1 more source
Identification of functional cis-regulatory elements by sequential enrichment from a randomized synthetic DNA library [PDF]
, 2013 BACKGROUND: The identification of endogenous cis-regulatory DNA elements (CREs) responsive to endogenous and environmental cues is important for studying gene regulation and for biotechnological applications but is labor and time intensive. Alternatively,
Ahmadinejad, N. +3 more
core +2 more sources