Results 21 to 30 of about 11,278 (212)
Action of Complexin on SNARE Complex [PDF]
Journal of Biological Chemistry, 2002 Calcium-dependent synaptic vesicle exocytosis requires three SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) proteins: synaptobrevin/vesicle-associated membrane protein in the vesicular membrane and syntaxin and SNAP-25 in the presynaptic membrane.
Kuang, Hu +3 more
openaire +2 more sources
Complexin/Synaptotagmin Interplay Controls Acrosomal Exocytosis [PDF]
Journal of Biological Chemistry, 2007 La secreción regulada es un proceso fundamental que subyace a la función de muchos tipos de células. En particular, la exocitosis acrosómica en espermatozoides de mamíferos es esencial para la fertilización de óvulos. La secreción regulada requiere proteínas SNARE y, en las neuronas, también sinaptotagmina I y complexina.
Carlos M. Roggero +5 more
openaire +2 more sources
Accessory Alpha-Helix of Complexin I Can Displace VAMP2 Locally in the Complexin-Snare Quaternary Complex [PDF]
Biophysical Journal, 2010 The calcium-triggered neurotransmitter release requires three SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins: synaptobrevin 2 (or vesicle-associated membrane protein 2) on the synaptic vesicle and syntaxin 1 and SNAP-25 (synaptosome-associated protein of 25 kDa) at the presynaptic plasma membrane.
Lu, Bin, Song, Shuang, Shin, Yeon-Kyun
openaire +3 more sources
CaMKIIalpha interacts with multi-PDZ domain protein MUPP1 in spermatozoa and prevents spontaneous acrosomal exocytosis [PDF]
, 2009 The success of acrosomal exocytosis, a complex process with a variety of inter-related steps, relies on the coordinated interaction of participating signaling molecules.
Ackermann, Frauke +5 more
core +1 more source
The rab3A-22A chimera prevents sperm exocytosis by stabilizing open fusion pores [PDF]
, 2016 At the final stage of exocytotis, a fusion pore opens between the plasma and a secretory vesicle membranes; typically, when the pore dilates the vesicle releases its cargo.
Bustos, Matias Alberto +5 more
core +1 more source
eLife, 2016 Complexin regulates spontaneous and activates Ca2+-triggered neurotransmitter release, yet the molecular mechanisms are still unclear. Here we performed single molecule fluorescence resonance energy transfer experiments and uncovered two conformations of
Ucheor B Choi +4 more
doaj +1 more source
Analysis of tripartite Synaptotagmin‐1‐SNARE‐complexin‐1 complexes in solution
FEBS Open Bio, 2023 Characterizing interactions of Synaptotagmin‐1 with the SNARE complex is crucial to understand the mechanism of neurotransmitter release. X‐ray crystallography revealed how the Synaptotagmin‐1 C2B domain binds to the SNARE complex through a so‐called ...
Klaudia Jaczynska +8 more
doaj +1 more source
, 1985 Number of Pages: 2Integrative BiologyGeological ...
McCoy, C. J., Vogt, Richard C.
core +1 more source
Regulation of Syntaxin3B-Mediated Membrane Fusion by T14, Munc18, and Complexin
Biomolecules, 2023 Retinal neurons that form ribbon-style synapses operate over a wide dynamic range, continuously relaying visual information to their downstream targets.
Rajkishor Nishad +4 more
doaj +1 more source
Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis
eLife, 2020 Calcium (Ca2+)-evoked release of neurotransmitters from synaptic vesicles requires mechanisms both to prevent un-initiated fusion of vesicles (clamping) and to trigger fusion following Ca2+-influx. The principal components involved in these processes are
Sathish Ramakrishnan +4 more
doaj +1 more source