Results 41 to 50 of about 11,278 (212)
Re-visiting the trans insertion model for complexin clamping
eLife, 2015 We have previously proposed that complexin cross-links multiple pre-fusion SNARE complexes via a trans interaction to function as a clamp on SNARE-mediated neurotransmitter release.
Shyam S Krishnakumar +7 more
doaj +1 more source
Time-coded neurotransmitter release at excitatory and inhibitory synapses. [PDF]
, 2016 Communication between neurons at chemical synapses is regulated by hundreds of different proteins that control the release of neurotransmitter that is packaged in vesicles, transported to an active zone, and released when an input spike occurs ...
Afia B. Ali +8 more
core +2 more sources
Complexin: Does It Deserve Its Name? [PDF]
Neuron, 2010 Knockout and other perturbations of complexins have provided important insights and elicited controversies about their role in neurotransmitter release. New work by Yang et al. in this issue of Neuron adds important detail and complexity to existing concepts-particularly on the nature of a Ca(2+)-dependent complexin-synaptotagmin switch for the ...
openaire +4 more sources
Activity-dependence of synaptic vesicle dynamics [PDF]
, 2017 The proper function of synapses relies on efficient recycling of synaptic vesicles. The small size of synaptic boutons has hampered efforts to define the dynamical states of vesicles during recycling.
Forte, Luca A +2 more
core +2 more sources
Early motor development is abnormal in complexin 1 knockout mice
Neurobiology of Disease, 2007 Complexin I expression is dysregulated in a number of neurological diseases including schizophrenia and depression. Adult complexin 1 knockout (Cplx1−/−) mice are severely ataxic and show deficits in exploration and emotional reactivity.
Dervila Glynn +2 more
doaj +1 more source
The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation [PDF]
, 2016 A dynamic, properly organised actin cytoskeleton is critical for the production and haemostatic function of platelets. The Wiskott Aldrich Syndrome protein (WASp) and Actin-Related Proteins 2 & 3 Complex (Arp2/3 complex) are critical mediators of ...
Bem, Danai +5 more
core +4 more sources
eLife, 2017 Neurotransmitter release depends on the SNARE complex formed by syntaxin-1, synaptobrevin and SNAP-25, as well as on complexins, which bind to the SNARE complex and play active and inhibitory roles. A crystal structure of a Complexin-I fragment bearing a
Eric A Prinslow +2 more
doaj +1 more source
Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice [PDF]
, 2015 Brain cholesterol biosynthesis and cholesterol levels are reduced in mouse models of Huntington's disease (HD), suggesting that locally synthesized, newly formed cholesterol is less available to neurons.
Alessandro Vercelli +22 more
core +4 more sources
Evolutionary conservation of complexins: from choanoflagellates to mice [PDF]
EMBO reports, 2015 Complexins are synaptic SNARE complex-binding proteins that cooperate with synaptotagmins in activating Ca(2+)-stimulated, synaptotagmin-dependent synaptic vesicle exocytosis and in clamping spontaneous, synaptotagmin-independent synaptic vesicle exocytosis. Here, we show that complexin sequences are conserved in some non-metazoan unicellular organisms
Xiaofei, Yang +5 more
openaire +2 more sources
Complexin and Ca2+ stimulate SNARE-mediated membrane fusion [PDF]
Nature Structural & Molecular Biology, 2008 Ca(2+)-triggered, synchronized synaptic vesicle fusion underlies interneuronal communication. Complexin is a major binding partner of the SNARE complex, the core fusion machinery at the presynapse. The physiological data on complexin, however, have been at odds with each other, making delineation of its molecular function difficult.
Yoon, TY Yoon, Tae-Young +5 more
openaire +3 more sources