Results 61 to 70 of about 11,278 (212)
Multiple Longitudinal Tracts in the Cephalopod Arm Sensorimotor System
Journal of Comparative Neurology, Volume 534, Issue 5, May 2026.Octopuses have a rich behavioral repertoire, coordinating complex movements along the length of an arm. The neural circuits controlling these behaviors are poorly understood. We employ tract‐tracing to investigate longitudinal tracts in the octopus arm.
Cassady S. Olson, Clifton W. Ragsdale
wiley +1 more source
Protein phase separation hotspots at the presynapse
Open Biology, 2022 Fundamental discoveries have shaped our molecular understanding of presynaptic processes, such as neurotransmitter release, active zone organization and mechanisms of synaptic vesicle (SV) recycling.
Janin Lautenschläger
doaj +1 more source
In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties.
, 2019 Regulated exocytosis of synaptic vesicles is substantially faster than of endocrine dense core vesicles despite similar molecular machineries. The reasons for this difference are unknown and could be due to different regulatory proteins, different ...
Castle, J. +10 more
core +1 more source
Annals of Neurology, Volume 99, Issue 3, Page 796-808, March 2026.Objective De novo mutations in the syntaxin‐binding protein 1 (STXBP1), encoded by STXBP1, are among the most prevalent causes of variable neurodevelopmental disorders, including epileptic encephalopathy, developmental delay, and movement disorders.
Tao Yang +10 more
wiley +1 more source
A mechanism for exocytotic arrest by the Complexin C-terminus
eLife, 2018 ComplexinII (CpxII) inhibits non-synchronized vesicle fusion, but the underlying mechanisms have remained unclear. Here, we provide evidence that the far C-terminal domain (CTD) of CpxII interferes with SNARE assembly, thereby arresting tonic exocytosis.
Mazen Makke +9 more
doaj +1 more source
Differences in human cortical gene expression match the temporal properties of large-scale functional networks. [PDF]
PLoS ONE, 2014 We explore the relationships between the cortex functional organization and genetic expression (as provided by the Allen Human Brain Atlas). Previous work suggests that functional cortical networks (resting state and task based) are organized as two ...
Claudia Cioli +4 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2023 Nerve terminals release neuronal transmitters at morphological specializations known as active zones (AZs). Synaptic vesicle fusion at individual AZs is probabilistic, and this property is fundamental for the neuronal information transfer. Until recently,
Maria Bykhovskaia
doaj +1 more source
Hypothesis - buttressed rings assemble, clamp, and release SNAREpins for synaptic transmission [PDF]
, 2017 Neural networks are optimized to detect temporal coincidence on the millisecond timescale. Here, we offer a synthetic hypothesis based on recent structural insights into SNAREs and the C2 domain proteins to explain how synaptic transmission can keep this
Grushin, K +3 more
core +1 more source
Genes, Brain and Behavior, Volume 25, Issue 1, February 2026.Buccal ganglia inter‐ and motoneuronal transcriptional changes were investigated after learning food is inedible (LFI) in Aplysia californica reared on different diets at two ages. Those reared on calorie restriction showed delayed signs of aging and maintained their performance in LFI when aged while those reared on ad‐lib did not. ABSTRACT Along with
Eric C. Randolph, Lynne A. Fieber
wiley +1 more source
NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin
eLife, 2018 SNARE complex disassembly by the ATPase NSF is essential for neurotransmitter release and other membrane trafficking processes. We developed a single-molecule FRET assay to monitor repeated rounds of NSF-mediated disassembly and reassembly of individual ...
Ucheor B Choi +6 more
doaj +1 more source