Results 31 to 40 of about 11,278 (212)
eLife, 2014 Previously we showed that fast Ca2+-triggered vesicle fusion with reconstituted neuronal SNAREs and synaptotagmin-1 begins from an initial hemifusion-free membrane point contact, rather than a hemifusion diaphragm, using a single vesicle–vesicle lipid ...
Ying Lai +6 more
doaj +1 more source
FEBS Open Bio, 2022 The mechanism of neurotransmitter release has been extensively characterized, showing that vesicle fusion is mediated by the SNARE complex formed by syntaxin‐1, SNAP‐25 and synaptobrevin. This complex is disassembled by N‐ethylmaleimide sensitive factor (
Josep Rizo +3 more
doaj +1 more source
Molecular Dynamics Simulations of the Proteins Regulating Synaptic Vesicle Fusion
Membranes, 2023 Neuronal transmitters are packaged in synaptic vesicles (SVs) and released by the fusion of SVs with the presynaptic membrane (PM). An inflow of Ca2+ into the nerve terminal triggers fusion, and the SV-associated protein Synaptotagmin 1 (Syt1) serves as ...
Maria Bykhovskaia
doaj +1 more source
A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain. [PDF]
JOR SpineThis review explores the therapeutic potential of naturally occurring venom‐derived peptides, particularly from reptiles and insects, as novel calcium channel blockers for managing chronic low back pain caused by intervertebral disc degeneration.
Melrose J +4 more
europepmc +2 more sources
eLife, 2016 Altered insulin signaling has been linked to widespread nervous system dysfunction including cognitive dysfunction, neuropathy and susceptibility to neurodegenerative disease.
Rebekah Elizabeth Mahoney +2 more
doaj +1 more source
Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release [PDF]
, 2010 The SNARE-binding protein complexin (Cpx) has been demonstrated to regulate synaptic vesicle fusion. Previous studies are consistent with Cpx functioning either as a synaptic vesicle fusion clamp to prevent premature exocytosis, or as a facilitator to ...
Cho, Richard W. +2 more
core +1 more source
Postsynaptic Complexin Controls AMPA Receptor Exocytosis during LTP [PDF]
Neuron, 2012 Long-term potentiation (LTP) is a compelling synaptic correlate of learning and memory. LTP induction requires NMDA receptor (NMDAR) activation, which triggers SNARE-dependent exocytosis of AMPA receptors (AMPARs). However, the molecular mechanisms mediating AMPAR exocytosis induced by NMDAR activation remain largely unknown.
Ahmad, Mohiuddin +6 more
openaire +2 more sources
Frontiers in Molecular Neuroscience, 2018 Complexins, binding to assembling soluble NSF-attachment protein receptor (SNARE) complexes, activate Ca2+ triggered exocytosis and clamp spontaneous release in the presynaptic terminal. Functions of complexin are structural dependent and mechanistically
Yi Yu +5 more
doaj +1 more source
eLife, 2022 Synaptic vesicles are primed into a state that is ready for fast neurotransmitter release upon Ca2+-binding to Synaptotagmin-1. This state likely includes trans-SNARE complexes between the vesicle and plasma membranes that are bound to Synaptotagmin-1 ...
Josep Rizo +4 more
doaj +1 more source
Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4 [PDF]
Journal of Cell Science, 2009 Complexins regulate the speed and Ca2+ sensitivity of SNARE-mediated synaptic vesicle fusion at conventional synapses. Two of the vertebrate complexins, Cplx3 and Cplx4, are specifically localized to retinal ribbon synapses. To test whether Cplx3 and Cplx4 contribute to the highly efficient transmitter release at ribbon synapses, we studied retina ...
Reim, K. +7 more
openaire +4 more sources