Results 31 to 40 of about 11,073 (199)

Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis

eLife, 2020
Calcium (Ca2+)-evoked release of neurotransmitters from synaptic vesicles requires mechanisms both to prevent un-initiated fusion of vesicles (clamping) and to trigger fusion following Ca2+-influx. The principal components involved in these processes are
Sathish Ramakrishnan, Manindra Bera, Jeff Coleman, James E Rothman, Shyam S Krishnakumar   +4 more
doaj   +1 more source

Pseudemys alabamensis [PDF]

, 1985
Number of Pages: 2Integrative BiologyGeological ...
McCoy, C. J., Vogt, Richard C.
core   +1 more source

Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms

eLife, 2014
Previously we showed that fast Ca2+-triggered vesicle fusion with reconstituted neuronal SNAREs and synaptotagmin-1 begins from an initial hemifusion-free membrane point contact, rather than a hemifusion diaphragm, using a single vesicle–vesicle lipid ...
Ying Lai, Jiajie Diao, Daniel J Cipriano, Yunxiang Zhang, Richard A Pfuetzner, Mark S Padolina, Axel T Brunger   +6 more
doaj   +1 more source

On the difficulties of characterizing weak protein interactions that are critical for neurotransmitter release

FEBS Open Bio, 2022
The mechanism of neurotransmitter release has been extensively characterized, showing that vesicle fusion is mediated by the SNARE complex formed by syntaxin‐1, SNAP‐25 and synaptobrevin. This complex is disassembled by N‐ethylmaleimide sensitive factor (
Josep Rizo, Guillaume David, Michael E. Fealey, Klaudia Jaczynska   +3 more
doaj   +1 more source

Molecular Dynamics Simulations of the Proteins Regulating Synaptic Vesicle Fusion

Membranes, 2023
Neuronal transmitters are packaged in synaptic vesicles (SVs) and released by the fusion of SVs with the presynaptic membrane (PM). An inflow of Ca2+ into the nerve terminal triggers fusion, and the SV-associated protein Synaptotagmin 1 (Syt1) serves as ...
Maria Bykhovskaia
doaj   +1 more source

Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release [PDF]

, 2010
The SNARE-binding protein complexin (Cpx) has been demonstrated to regulate synaptic vesicle fusion. Previous studies are consistent with Cpx functioning either as a synaptic vesicle fusion clamp to prevent premature exocytosis, or as a facilitator to ...
Cho, Richard W., Littleton, J. Troy, Song, Yun   +2 more
core   +1 more source

Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery

eLife, 2016
Altered insulin signaling has been linked to widespread nervous system dysfunction including cognitive dysfunction, neuropathy and susceptibility to neurodegenerative disease.
Rebekah Elizabeth Mahoney, Jorge Azpurua, Benjamin A Eaton   +2 more
doaj   +1 more source

Postsynaptic Complexin Controls AMPA Receptor Exocytosis during LTP [PDF]

Neuron, 2012
Long-term potentiation (LTP) is a compelling synaptic correlate of learning and memory. LTP induction requires NMDA receptor (NMDAR) activation, which triggers SNARE-dependent exocytosis of AMPA receptors (AMPARs). However, the molecular mechanisms mediating AMPAR exocytosis induced by NMDAR activation remain largely unknown.
Ahmad, Mohiuddin, Polepalli, Jai S., Goswami, Debanjan, Yang, Xiaofei, Kaeser-Woo, Yea Jin, Südhof, Thomas C., Malenka, Robert C.   +6 more
openaire   +2 more sources

Accessory and Central α-helices of Complexin Selectively Activate Ca2+ Triggering of Synaptic Exocytosis

Frontiers in Molecular Neuroscience, 2018
Complexins, binding to assembling soluble NSF-attachment protein receptor (SNARE) complexes, activate Ca2+ triggered exocytosis and clamp spontaneous release in the presynaptic terminal. Functions of complexin are structural dependent and mechanistically
Yi Yu, Su Chen, Xiaoqiang Mo, Jihong Gong, Chenhong Li, Xiaofei Yang   +5 more
doaj   +1 more source

All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer

eLife, 2022
Synaptic vesicles are primed into a state that is ready for fast neurotransmitter release upon Ca2+-binding to Synaptotagmin-1. This state likely includes trans-SNARE complexes between the vesicle and plasma membranes that are bound to Synaptotagmin-1 ...
Josep Rizo, Levent Sari, Yife Qi, Wonpil Im, Milo M Lin   +4 more
doaj   +1 more source