Results 141 to 150 of about 3,671 (181)

The biomechanics of fish skin: assessing puncture resistance to the dynamic predatory mechanism of cone snails. [PDF]

J Exp Biol
Baskota B, Zhang B, Anderson PSL.
europepmc   +1 more source

Structural similarities reveal an expansive conotoxin family with a two-finger toxin fold. [PDF]

Protein Sci
Khilji MS, Hackney CM, Koch TL, Hone AJ, Rogalski A, Watkins M, Tun J, McIntosh JM, Olivera B, Safavi-Hemami H, Teilum K, Ellgaard L.   +11 more
europepmc   +1 more source

Molecular arms race classifier for decrypting venom peptide and ion channel interactions.

Digit Discov
Achimba F, Bybordi A, Gelashvili M, Ramirez J, Raja A, Qiu W, Holford M.   +6 more
europepmc   +1 more source

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Therapeutic Potential of Cone Snail Venom Peptides (Conopeptides)

Current Topics in Medicinal Chemistry, 2012
Cone snails have evolved many 1000s of small, structurally stable venom peptides (conopeptides) for prey capture and defense. Whilst < 0.1% have been pharmacologically characterised, those with known function typically target membrane proteins of therapeutic importance, including ion channels, transporters and GPCRs. Several conopeptides reduce pain in
Vetter, Irina, Lewis, Richard J.
openaire   +5 more sources

Structural and biosynthetic properties of peptides in cone snail venoms

Peptides, 1995
Venoms of the predatory cone snails Conus textile, Conus striatus, and Conus magus were subjected to comprehensive analysis of peptide content. With the fish-eating cone snails C. magus and C. striatus, the most abundant venom peptides were of > 30-50 residues, whereas the predominant peptides in the venom of the mollusc-eating snail, C.
Robert Newcomb
exaly   +3 more sources

Phyla Molluska: The Venom Apparatus of Cone Snails

2015
Predatory marine gastropods of the genus Conus comprise similar to 700 species that have evolved a highly specialized envenomation apparatus. This recently evolved genus has developed potent venoms separately for prey capture and defense. Both strategies utilize a complex but different cocktail of venom peptides that is injected through a hollow ...
Dutertre, Sebastien, Griffin, John, Lewis, Richard J.   +2 more
openaire   +3 more sources

Neurotoxins of Cone Snail Venoms

2002
Cone snails are predatory marine mollusks that rely on their venom components to immobilize and capture fish, worms, or other mollusks. Cones employ a number of prey-hunting strategies, ultimately involving the injection of venom through a hollow, harpoon-like, modified-tooth structure (1).
Robert Newcomb, George Miljanich
openaire   +1 more source

Pharmacology of predatory and defensive venom peptides in cone snails

Molecular BioSystems, 2017
Abstract Cone snails are predatory gastropods whose neurotoxic venom peptides (conotoxins) have been extensively studied for pharmacological probes, venom evolution mechanisms and potential therapeutics. Conotoxins have a wide range of structural and functional classes that continue to undergo accelerated evolution that underlies the ...
Jutty Rajan Prashanth, Sebastien Dutertre, Richard James Lewis   +2 more
openaire   +4 more sources

Novel Pharmacological Targets From Indian Cone Snails

Mini-Reviews in Medicinal Chemistry, 2011
The oceans are a source of combinatorial library of unique natural products, 'not found in the terrestrial environment'. Marine invertebrates such as sponges, molluscs, bryozoans, tunicates (Urochordata) and their associated microorganisms are the major representatives of promising bioactive compounds.
M Santhana, Ramasamy, S, Manikandan
openaire   +2 more sources