Results 51 to 60 of about 26,063 (225)
Three‐Dimensional Ovary Model to Improve and Study Murine Follicle Growth
Advanced Healthcare Materials, EarlyView.To develop new methods for fertility preservation in women, novel culture systems for small follicles need to be established. In this work, a poly(ethylene glycol) based scaffold, with appropriate mechanical and bioactive features to support mouse follicle and ovary cell growth is developed, and the formed cell‐follicle interactions are visualized ...
Mira Jacobs +6 more
wiley +1 more source
Blockade of Glial Connexin 43 Hemichannels Reduces Food Intake
Cells, 2020 The metabolic syndrome, which comprises obesity and diabetes, is a major public health problem and the awareness of energy homeostasis control remains an important worldwide issue. The energy balance is finely regulated by the central nervous system (CNS)
Florent Guillebaud +10 more
doaj +1 more source
Heliyon, 2023 Cadmium (Cd) is a significant environmental contaminant known for its potential hepatotoxic effects. However, the precise mechanisms underlying Cd-induced hepatotoxicity have yet to be fully understood.
Yuntian Duan +10 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Zinc‐containing bioactive glass (ZnBG) promotes diabetic wound healing by regulating macrophage extracellular traps (METs). Specifically, ZnBG reduces oxidative stress and inhibits the PAD4 and NLRP3/caspase‐1/GSDMD signaling pathways, thereby suppressing MET formation.
RuiYang Sun +11 more
wiley +1 more source
Plasma exosome-derived connexin43 as a promising biomarker for melanoma patients
BMC Cancer, 2023 Background To examine the levels of exosome-derived connexin 43 (Cx43) in plasma and estimate its forecast value in patients with melanoma. Methods We measured the plasma exosome-derived Cx43 levels in the plasma of 112 melanoma patients and 50 healthy ...
Yue Shen +4 more
doaj +1 more source
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced Science, EarlyView.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +1 more source
Advanced Science, EarlyView.This study develops a hierarchically porous hydrogel patch strategy (HPMP), based on gas‐shearing microfluidics and an aqueous two‐phase system to fabricate porous microgels as microgel‐based bioinks. The porous microgels with controllable porous structure exhibit excellent cellular behavior.
Ziyang Liu +13 more
wiley +1 more source
Expression of Connexin 43 in Granular Cell Tumors of the Skin, Tongue and Esophagus
Dermatopathology, 2023 Background: Granular cell tumors (GCT) are rare neoplasms of Schwann cell origin occurring in the skin and in other organs. The etiopathogenesis of GCT is yet poorly understood.
Hermann Kneitz +3 more
doaj +1 more source
Advanced Science, EarlyView.This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang +21 more
wiley +1 more source
Connexin 43 is Involved in Aldosterone-Induced Podocyte Injury
Cellular Physiology and Biochemistry, 2014 Background/Aims: Connexin43 (Cx43) belongs to a family of transmembrane proteins that build cell-to-cell channels in gap junctions, which play an essential role in intercellular communication, cell proliferation, differentiation and apoptosis. The aim of
Min Yang, Bin Wang, Min Li, Bo Jiang
doaj +1 more source