Results 51 to 60 of about 854 (148)

Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea [PDF]

, 2006
Gap junctional intercellular communication (GJIC) plays a major role in cochlear function. Recent evidence suggests that connexin 26 (Cx26) and Cx30 are the major constituent proteins of cochlear gap junction channels, possibly in a unique heteromeric ...
Jagger, DJ, Forge, A
core  

Hearing loss and pathological changes of cochlea in a mouse model carrying compound heterozygous variants in the Gjb2 non‐coding region

Eye &ENT Research, Volume 2, Issue 1, Page 43-52, March 2025.
Abstract Background GJB2 gene variants are the most important cause of sensorineural hearing loss. A large number of clinical studies have focused on coding region variants, and a significant proportion of patients with single coding region variants have unexplained clinical phenotypes.
Xinyu Shi, Xiaozhou Liu, Zhengdong Zhao, Yanjun Zong, Weijia Kong, Yu Sun   +5 more
wiley   +1 more source

Microanatomy of the human tunnel of Corti structures and cochlear partition‐tonotopic variations and transcellular signaling

Journal of Anatomy, Volume 245, Issue 2, Page 271-288, August 2024.
Mid‐modiolar semi‐thin section of a human cochlea with tonotopic estimates based on synchrotron 3‐D imaging. Abstract Auditory sensitivity and frequency resolution depend on the optimal transfer of sound‐induced vibrations from the basilar membrane (BM) to the inner hair cells (IHCs), the principal auditory receptors.
Dina Giese, Hao Li, Wei Liu, Karin Staxäng, Monika Hodik, Hanif M. Ladak, Sumit Agrawal, Anneliese Schrott‐Fischer, Rudolf Glueckert, Helge Rask‐Andersen   +9 more
wiley   +1 more source

Mammary gland specific knockdown of the physiological surge in Cx26 during lactation retains normal mammary gland development and function. [PDF]

PLoS ONE, 2014
Connexin26 (Cx26) is the major Cx protein expressed in the human mammary gland and is up-regulated during pregnancy while remaining elevated throughout lactation.
Michael K G Stewart, Isabelle Plante, John F Bechberger, Christian C Naus, Dale W Laird   +4 more
doaj   +1 more source

Heterotypic gap junction channels (connexin26-connexin32) violate the paradigm of unitary conductance.

, 1995
Human HeLa cells transfected with mouse DNA coding for connexin26 (Cx26) or connexin32 (Cx32) were used to examine the properties of heterotypic Cx26-Cx32 gap junction channels.
Willecke K, Bukauskas FF, Weingart R, Elfgang C   +3 more
core   +1 more source

The protective effects of systemic dexamethasone on sensory epithelial damage and hearing loss in targeted Cx26-null mice

Cell Death and Disease, 2022
Mutations in the GJB2 gene (encoding Connexin26(Cx26)) are the most common cause of hereditary deafness, accounting for about a quarter of all cases. Sensory epithelial damage is considered to be one of the main causes of deafness caused by GJB2 gene ...
Kai Xu, Sen Chen, Le Xie, Yue Qiu, Xiao-zhou Liu, Xue Bai, Yuan Jin, Xiao-hui Wang, Yu Sun   +8 more
doaj   +1 more source

Connexin32 can restore hearing in connexin26 deficient mice

, 2011
Functional gap junction channels composed of certain connexin proteins are essential for the function of the cochlea. Homozygous deficiency in the Gjb2 (mice) or GJB2 (human) gene coding for connexin26 (Cx26) in the cochlea leads to hearing impairment in
Degen, Joachim, Schuetz, Melanie, Melanie Jokwitz, Melanie Schütz, Nikolai Dicke, Jokwitz, Melanie, Klaus Willecke, Willecke, Klaus, Strenzke, Nicola, Dicke, Nikolai, Joachim Degen, Moser, Tobias, Nicola Strenzke, Tobias Moser   +13 more
core   +1 more source

Connexin and pannexin (hemi)channels in the liver

Frontiers in Physiology, 2014
The liver was among the first organs in which connexin proteins have been identified. Hepatocytes harbour connexin32 and connexin26, while non-parenchymal liver cells typically express connexin43.
Michaël eMaes, Elke eDecrock, Bruno eCogliati, André G Oliveira, Pedro E Marques, Maria Lucia eZaidan Dagli, Gustavo B Menezes, Gregory eMennecier, Luc eLeybaert, Tamara eVanhaecke, Vera eRogiers, Mathieu eVinken   +11 more
doaj   +1 more source

Whole-exome sequencing of de novo genetic variants in a Chinese family with a sporadic case of congenital nonsyndromic hearing loss [version 2; peer review: 2 approved]

F1000Research, 2021
Background: We examined the genetic variants of a Chinese family with a 22-month-old infant with sporadic non-syndromic sensorineural hearing loss (NSHL).
Sijing Hu, Hao Zhang, Yunqiang Liu, Mohan Liu, Jingjing Li, Shunyao Liao   +5 more
doaj   +1 more source

Modeling, applications and challenges of inner ear organoid

Smart Medicine, Volume 3, Issue 1, February 2024.
Advances in stem cell technology and organoid culture offer unique opportunities for modeling inner ear diseases and developing personalized therapies for hearing loss. Resources for the inner ear organoid construction are emphasized. Recent advancements in modeling technologies for inner ear organoids are presented. The application challenges of inner
Jieyu Qi, Liyan Zhang, Xiaohan Wang, Xin Chen, Yiyuan Li, Tian Wang, Peina Wu, Renjie Chai   +7 more
wiley   +1 more source