Analysis of trafficking, stability and function of human connexin 26 gap junction channels with deafness-causing mutations in the fourth transmembrane helix. [PDF]
PLoS ONE, 2013 Human Connexin26 gene mutations cause hearing loss. These hereditary mutations are the leading cause of childhood deafness worldwide. Mutations in gap junction proteins (connexins) can impair intercellular communication by eliminating protein synthesis ...
Cinzia Ambrosi +7 more
doaj +1 more source
Citrus Flavone Tangeretin Inhibits CRPC Cell Proliferation by Regulating Cx26, AKT, and AR Signaling
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022 Prostate cancer (PCa) progression depends on the action of androgen receptors (AR). Therefore, preventing ligand‐mediated activation of AR is the first‐line treatment strategy for metastatic PCa. Androgen deprivation therapy (ADT) can inhibit ligand binding to AR and alleviate PCa progression initially.
Ningfang Zhang +8 more
wiley +1 more source
Opposing modulation of Cx26 gap junctions and hemichannels by CO2
The Journal of Physiology, Volume 599, Issue 1, Page 103-118, 1 January 2021., 2021 Key points A moderate increase in (55 mmHg) closes Cx26 gap junctions. This effect of CO2 is independent of changes in intra‐ or extracellular pH. The CO2‐dependent closing effect depends on the same residues (K125 and R104) that are required for the CO2‐dependent opening of Cx26 hemichannels.
Sarbjit Nijjar +6 more
wiley +1 more source
Replacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heart [PDF]
, 2007 BackgroundIn order to further distinguish unique from general functions of connexin43, we have generated mice in which the coding region of connexin43 was replaced by that of connexin26.ResultsHeterozygous mothers showed impaired mammary gland ...
FREYER J +27 more
core +1 more source
Free energy and kinetics of cAMP permeation through connexin26 via applied voltage and milestoning. [PDF]
Biophys J, 2021 The connexin family is a diverse group of highly regulated wide-pore channels permeable to biological signaling molecules. Despite the critical roles of connexins in mediating selective molecular signaling in health and disease, the basis of molecular ...
Jiang W +6 more
europepmc +2 more sources
Bengal Journal of Otolaryngology and Head Neck Surgery, 2021 Introduction An important accompaniment of Non-syndromic sensorineural hearing loss is family history and consanguinity. One of the widely studied single nucleotide polymorphism is the gap junction protein beta-2 (GJB2) gene which encodes the protein ...
Gangadhara KS, Geetha Bhaktha, Manjula B
doaj +3 more sources
Gap junction structure: unraveled, but not fully revealed [version 1; referees: 3 approved]
F1000Research, 2017 Gap junction channels facilitate the intercellular exchange of ions and small molecules, a process that is critical for the function of many different kinds of cells and tissues.
Eric C. Beyer, Viviana M. Berthoud
doaj +1 more source
Connexin channels and phospholipids: association and modulation
BMC Biology, 2009 Background For membrane proteins, lipids provide a structural framework and means to modulate function. Paired connexin hemichannels form the intercellular channels that compose gap junction plaques while unpaired hemichannels have regulated functions in
Harris Andrew L, Locke Darren
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Reduced expression of multiple gap junction proteins is a feature of cervical dysplasia
Molecular Cancer, 2005 Cervical dysplasia is a premalignant lesion associated with human papillomavirus (HPV) infection which, over time, can turn cancerous. Previous studies have indicated that loss of gap junctions may be a feature of cervical cancer and premalignant ...
Edward Mike +3 more
doaj +1 more source
Divalent regulation and intersubunit interactions of human Connexin26 (Cx26) hemichannels [PDF]
, 2014 Control of plasma membrane connexin hemichannel opening is indispensable, and is achieved by physiological extracellular divalent ion concentrations.
Harris, Andrew L +3 more
core +1 more source