Results 21 to 30 of about 854 (148)

Repression of Connexin26 hemichannel activity protects the barrier function of respiratory airway epithelial cells against LPS-induced alteration [PDF]

Cell Communication and Signaling
In respiratory airway epithelial cells, lipopolysaccharide (LPS) treatment induced an enhancement of connexin 26 (Cx26) hemichannel activity shown by dye uptake experiments after siRNA-mediated knock-down of Cx26.
Tina Lehrich, Anne Dierks, Masina Plenge, Helena Obernolte, Klaudia Grieger, Katherina Sewald, Frederic Rodriguez, Lucie Malet, Peter Braubach, Florence Bedos-Belval, Anaclet Ngezahayo   +10 more
doaj   +2 more sources

Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa. [PDF]

PLoS ONE, 2017
ClockΔ19/Δ19 mice is an experimental model mouse for nocturia (NOC). Using the bladder mucosa obtained from ClockΔ19/Δ19 mice, we investigated the gene expression rhythms of mechanosensory cation channels such as transient receptor potential cation ...
Tatsuya Ihara, Takahiko Mitsui, Yuki Nakamura, Satoru Kira, Hiroshi Nakagomi, Norifumi Sawada, Yuri Hirayama, Keisuke Shibata, Eiji Shigetomi, Yoichi Shinozaki, Mitsuharu Yoshiyama, Karl-Erik Andersson, Atsuhito Nakao, Masayuki Takeda, Schuichi Koizumi   +14 more
doaj   +2 more sources

Therapeutic effect of Arthrocnemum machrostachyum methanolic extract on Ehrlich solid tumor in mice

BMC Complementary Medicine and Therapies, 2020
Background The anti-cancer effect of the halophyte Arthrocnemum indicum, a member of Arthrocnemum family of salt-tolerant plants, was evaluated against colorectal cancer cell, CaCo2.
Zeina W. Sharawi
doaj   +2 more sources

Conformational changes and CO₂-induced channel gating in connexin26. [PDF]

Structure, 2022
Connexins form large-pore channels that function either as dodecameric gap junctions or hexameric hemichannels to allow the regulated movement of small molecules and ions across cell membranes.
Brotherton DH, Savva CG, Ragan TJ, Dale N, Cameron AD.   +4 more
europepmc   +2 more sources

Connexin30-Deficiency Causes Mild Hearing Loss With the Reduction of Endocochlear Potential and ATP Release

Frontiers in Cellular Neuroscience, 2022
GJB2 and GJB6 are adjacent genes encoding connexin 26 (Cx26) and connexin 30 (Cx30), respectively, with overlapping expressions in the inner ear. Both genes are associated with the commonest monogenic hearing disorder, recessive isolated deafness DFNB1 ...
Junmin Chen, Junmin Chen, Junmin Chen, Penghui Chen, Penghui Chen, Penghui Chen, Baihui He, Baihui He, Baihui He, Tianyu Gong, Tianyu Gong, Tianyu Gong, Yue Li, Yue Li, Yue Li, Jifang Zhang, Jifang Zhang, Jifang Zhang, Jingrong Lv, Jingrong Lv, Jingrong Lv, Fabio Mammano, Fabio Mammano, Shule Hou, Shule Hou, Shule Hou, Jun Yang, Jun Yang, Jun Yang   +28 more
doaj   +1 more source

CO₂ sensing by connexin26 and its role in the control of breathing. [PDF]

Interface Focus, 2021
Breathing is essential to provide the O2 required for metabolism and to remove its inevitable CO2 by-product. The rate and depth of breathing is controlled to regulate the excretion of CO2 to maintain the pH of arterial blood at physiological values.
Dale N.
europepmc   +2 more sources

Subcellular Localization of Connexin 26 in Cardiomyocytes and in Cardiomyocyte-Derived Extracellular Vesicles

Molecules, 2021
Connexins (Cxs) are a family of membrane-spanning proteins, expressed in vertebrates and named according to their molecular weight. They are involved in tissue homeostasis, and they function by acting at several communication levels.
Alessandra Falleni, Stefania Moscato, Antonietta R. M. Sabbatini, Margherita Bernardeschi, Francesco Bianchi, Antonella Cecchettini, Letizia Mattii   +6 more
doaj   +1 more source

A putative adverse outcome network for neonatal mortality and lower birth weight in rodents: Applicability to per‐ and polyfluoroalkyl substances and relevance to human health

Birth Defects Research, Volume 115, Issue 11, Page 1011-1062, June 15, 2023., 2023
Abstract Background Some per‐ and poly‐fluoroalkyl substances (PFAS) cause neonatal mortality and lower birth weight in rodents. We constructed an Adverse Outcome Pathway (AOP) network for neonatal mortality and lower birth weight in rodents, comprising three putative AOPs.
John M. Rogers, Melissa M. Heintz, Chad M. Thompson, Laurie C. Haws   +3 more
wiley   +1 more source

Cytoplasmic localization of connexin 26 suppresses transition of β‐catenin into the nucleus in intestinal‐ and mix‐type gastric cancer

Annals of Gastroenterological Surgery, Volume 6, Issue 4, Page 505-514, July 2022., 2022
Cytoplasmic Cx26 was found to be a prognostic factor in intestinal‐ and mix‐type gastric cancer. We revealed that cytoplasmic Cx26 inhibits the translocation of β‐catenin to the nucleus. Abstract Background Connexin is a basic molecule that forms gap junctions and undergoes localization changes to the cytoplasm in association with carcinogenesis.
Nobuhiro Nakazawa, Makoto Sohda, Takehiko Yokobori, Navchaa Gombodorj, Akihiko Sano, Makoto Sakai, Tetsunari Oyama, Hiroyuki Kuwano, Ken Shirabe, Hiroshi Saeki   +9 more
wiley   +1 more source

Generation of hiPSC line UMi030-A from an individual with the hearing loss-related GJB2 mutation c.109G > A

Stem Cell Research, 2022
Genetic variants in the GJB2 gene which encodes for the Connexin 26 protein account for ∼ 60% of cases of genetic hearing loss. A novel hiPSC line was generated from an individual with the hearing loss-related variant c.109G > A in GJB2 leading to the p ...
Brett M. Colbert, Nicholas C. Gosstola, Derek M. Dykxhoorn, Xue Zhong Liu   +3 more
doaj   +1 more source