Results 1 to 10 of about 854 (148)

Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development [PDF]

Advanced Science
Gap junction Beta 2 Protein (GJB2, Connexin26, Cx26), the primary genetic cause of hereditary hearing loss (25%–50% of cases), has been exclusively regarded as forming an intercellular channel that mediates rapid communication.
Xiaozhou Liu, Le Xie, Yuan Jin, Sen Chen, Xinyu Shi, Yanjun Zong, Zhengdong Zhao, Wei‐Jia Kong, Yu Sun   +8 more
doaj   +3 more sources

Degradation of cochlear Connexin26 accelerate the development of age-related hearing loss [PDF]

Aging Cell, 2023
In this paper, our results support the hypothesis that reduction of Cx26 and disruption of GJPs in the cochlea contribute to the development and progression of age‐related hearing loss. The degradation of Cx26 tends to occur in the early stages of age‐related hearing loss. Therefore, it can be used as an early warning marker of age‐related hearing loss.
Weijia Kong, Yue Qiu, Yu Sun
exaly   +3 more sources

Metformin suppresses NFE2L1 pathway activation to inhibit gap junction beta protein expression in NSCLC [PDF]

Cancer Medicine
Objective Non‐small‐cell lung cancer (NSCLC) is a deadly form of cancer that exhibits extensive intercellular communication which contributed to chemoradiotherapy resistance.
Shuo Yu, Hui Ren, Tingting Liu, Xiaoyan Han, Hui Guo, Qian Ning, Yang Li, Hong Zhou, Mingwei Chen, Tinghua Hu   +9 more
doaj   +3 more sources

Pathological mechanisms of connexin26-related hearing loss: Potassium recycling, ATP-calcium signaling, or energy supply? [PDF]

Frontiers in Molecular Neuroscience, 2022
Hereditary deafness is one of the most common human birth defects. GJB2 gene mutation is the most genetic etiology. Gap junction protein 26 (connexin26, Cx26) encoded by the GJB2 gene, which is responsible for intercellular substance transfer and signal ...
Penghui Chen, Penghui Chen, Penghui Chen, Wenjin Wu, Wenjin Wu, Wenjin Wu, Jifang Zhang, Jifang Zhang, Jifang Zhang, Junmin Chen, Junmin Chen, Junmin Chen, Yue Li, Yue Li, Yue Li, Lianhua Sun, Lianhua Sun, Lianhua Sun, Shule Hou, Shule Hou, Shule Hou, Jun Yang, Jun Yang, Jun Yang   +23 more
doaj   +2 more sources

UHRF1-induced connexin26 methylation is involved in hearing damage triggered by intermittent hypoxia in neonatal rats [PDF]

Open Medicine, 2023
Ubiquitin-like with plant homeodomain and ring finger domains 1 (UHRF1) promotes the maintenance of established patterns of DNA methylation in mammalian cells.
Zhang Xingang, Zheng Jishan, Xu Huiqing, Ma Zhaoxin   +3 more
doaj   +2 more sources

F-Actin Dysplasia Involved in Organ of Corti Deformity in Gjb2 Knockdown Mouse Model [PDF]

Frontiers in Molecular Neuroscience, 2022
Mutations in the GJB2 gene encoding connexin26 (Cx26) protein are one of the most common causes of hereditary deafness. Previous studies have found that different Cx26-null mouse models have severe hearing loss and deformity of the organ of Corti (OC) as
Xiao-zhou Liu, Yuan Jin, Sen Chen, Kai Xu, Le Xie, Yue Qiu, Xiao-hui Wang, Yu Sun, Yu Sun, Wei-jia Kong, Wei-jia Kong   +10 more
doaj   +2 more sources

PARP inhibitor rescues hearing and hair cell impairment in Cx26‐null mice

View, 2023
GJB2 (encoding connexin26, Cx26) mutation is the most common genetic cause of hereditary deafness. Cochlear sensory hair cell (HC) death is the core pathologic phenomenon of GJB2‐related deafness. However, mechanism‐based therapy is still obscure.
Xiaohui Wang, Sen Chen, Yue Qiu, Kai Xu, Xue Bai, Le Xie, Weijia Kong, Yu Sun   +7 more
doaj   +2 more sources

Connexin26 Modulates the Radiosensitivity of Cutaneous Squamous Cell Carcinoma by Regulating the Activation of the MAPK/NF-κB Signaling Pathway [PDF]

Frontiers in Cell and Developmental Biology, 2021
Previous studies have confirmed that the gap junction protein Connexin26 (Cx26) is specifically expressed in human skin tissue. Cx26 can transmit radiation-induced damage signals.
Minqiong Sun, Yuan Li, Jing Qian, Siwei Ding, Mingyu Sun, Mingyu Sun, Bowen Tan, Ye Zhao   +7 more
doaj   +2 more sources

Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO2 [PDF]

eLife
Connexins allow intercellular communication by forming gap junction channels (GJCs) between juxtaposed cells. Connexin26 (Cx26) can be regulated directly by CO2. This is proposed to be mediated through carbamylation of K125. We show that mutating K125 to
Deborah H Brotherton, Sarbjit Nijjar, Christos G Savva, Nicholas Dale, Alexander David Cameron   +4 more
doaj   +2 more sources

Porokeratotic Eccrine Ostial and Dermal Duct Nevus: A Report of Rare Late-Onset Solitary Lesion [PDF]

Clinical, Cosmetic and Investigational Dermatology
Kasama Tejapira, Poonkiat Suchonwanit Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Poonkiat Suchonwanit, Division of Dermatology, Department of Medicine ...
Tejapira K, Suchonwanit P
doaj   +2 more sources