Results 41 to 50 of about 854 (148)

Developmental abnormalities in supporting cell phalangeal processes and cytoskeleton in the Gjb2 knockdown mouse model

Disease Models & Mechanisms, 2018
Mutations in the GJB2 gene [which encodes connexin 26 (Cx26)] are the most common causes of hereditary hearing loss in humans, and previous studies showed postnatal development arrest of the organ of Corti in different Cx26-null mouse models.
Sen Chen, Le Xie, Kai Xu, Hai-Yan Cao, Xia Wu, Xiao-Xiang Xu, Yu Sun, Wei-Jia Kong   +7 more
doaj   +1 more source

Porokeratotic Eccrine Nevus May Be Caused by Somatic Connexin26 Mutations [PDF]

, 2012
Porokeratotic eccrine ostial and dermal duct nevus, or porokeratotic eccrine nevus (PEN), is a hyperkeratotic epidermal nevus. Several cases of widespread involvement have been reported, including one in association with the keratitis–ichthyosis–deafness
Kamps, Miriam A.F., Steijlen, Peter M, Steijlen, Peter M., van Geel, Michel, Geel, Michael van, van Steensel, Maurice A. M., Janssens, René, Easton, Jennifer A, Kamps, Miriam A. F., Tadini, Gianluca, Martin, Patricia E, van Steensel, Maurice A M, Martin, Patricia E., Easton, Jennifer A., van Steensel, Maurice A.M., Donnelly, Steven, Happle, Rudolf, Kamps, Miriam A F   +17 more
core   +1 more source

Connexin26-mediated transfer of laterality cues in Xenopus

Biology Open, 2012
Summary A cilia-driven leftward flow of extracellular fluid breaks bilateral symmetry in the dorsal midline of the neurula stage vertebrate embryo.
Tina Beyer, Thomas Thumberger, Axel Schweickert, Martin Blum   +3 more
doaj   +1 more source

Aberrant Connexin26 Hemichannels Underlying Keratitis–Ichthyosis–Deafness Syndrome Are Potently Inhibited by Mefloquine [PDF]

, 2015
Keratitis–ichthyosis–deafness (KID) syndrome is an ectodermal dysplasia caused by dominant mutations of connexin26 (Cx26). Loss of Cx26 function causes nonsyndromic sensorineural deafness, without consequence in the epidermis.
Li, Leping, Wang, Hong-Zhan, Levit, Noah A., White, Thomas W., Sellitto, Caterina, Srinivas, Miduturu, Brink, Peter R.   +6 more
core   +1 more source

Connexins in Acquired Hearing Loss: Expanding Research Perspectives

Biomedicines
Connexins, as key players in intercellular communication in the inner ear, are vital for maintaining normal hearing function. While numerous studies have explored their role in congenital hereditary hearing loss, the underlying mechanisms and therapeutic
Sihan Huang, Jingyi Zhu, Jifang Zhang, Tianyu Gong, Zhongyuan Fei, Penghui Chen, Shule Hou, Jun Yang   +7 more
doaj   +1 more source

Mechanism Underlying the Protective Effect of Tempol and Nω-Nitro-l-arginine Methyl Ester on Acoustic Injury: Possible Involvement of c-Jun N-Terminal Kinase Pathway and Connexin26 in the Cochlear Spiral Ligament

Journal of Pharmacological Sciences, 2010
There is evidence that reactive oxygen species (ROS) are formed in the cochlea during acoustic injury. However, very little is known about the involvement of ROS signals in the spiral ligament (SL) during such injury.
Reiko Nagashima, Taro Yamaguchi, Hajime Tanaka, Kiyokazu Ogita   +3 more
doaj   +1 more source

Prävalenzen von Mutationen auf dem kodierenden Exon2 des Connexin26 Genes in einem Patientenkollektiv einer mitteldeutschen Klinik [PDF]

, 2005
Mutationen auf dem Connexin26 Gen – insbesondere die Mutation Gdel35 scheint in bestimmten Populationen für bis zu 50% sporadischer und familiärer frühkindlicher Schwerhörigkeit verantwortlich zu sein.
Wolf, Armin Hilmar
core  

Chinese Clinical Practice Guidelines for Auditory Neuropathy (gCAN)

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 1, Page 1-24, February 2026.
ABSTRACT Auditory neuropathy (AN) is an auditory disorder that affects the function of the auditory pathway. An increasing number of AN cases have been identified with the revelation of the underlying mechanisms, the advancements of diagnostic and detecting techniques.
Chinese Multi‐Center Research Collaborative Group on Clinical Diagnosis and Intervention of Auditory Neuropathy, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association, Society of Audiology and Vestibular Medicine, China International Exchange and Promotive Association for Medical and Health Care   +5 more
wiley   +1 more source

Connexin43 Expression Increases in the Epithelium and Stroma along the Colonic Neoplastic Progression Pathway: Implications for Its Oncogenic Role

Gastroenterology Research and Practice, Volume 2011, Issue 1, 2011., 2011
Connexins (Cxs) are critical for normal tissue development, differentiation, and cell proliferation. Normal expression and function of Cxs are considered to play a role in tumor suppression, but abnormal localization and abnormally increased expression of Cxs have been found in a variety of carcinomas.
Yusheng Han, Paul J. Zhang, Terina Chen, Sabrina W. Yum, Teresa Pasha, Emma E. Furth, Gianfranco D. Alpini   +6 more
wiley   +1 more source

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, Volume 12, Issue 29, August 7, 2025.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source