Results 21 to 30 of about 1,550 (182)
MedComm, Volume 4, Issue 5, October 2023., 2023 Single‐cell RNA sequencing analysis revealed the metabolic remodeling from aerobic glycolysis toward oxidative phosphorylation and a specific degenerative rod subpopulation in highly myopic photoreceptors. Neurodegeneration was generally discovered in highly myopic retinal neurons with imbalanced ON/OFF signaling.
Yunqian Yao +5 more
wiley +1 more source
Connexin45 colocalization patterns in the plexiform layers of the developing mouse retina
Journal of Anatomy, Volume 243, Issue 2, Page 258-264, August 2023., 2023 Abstract Chemical and electrical synapses (gap junctions) are widely prevalent in the nervous system. Gap junctions emerge long before chemical synapses, allowing communication between developing cells, and are thought to be involved in establishing neural circuits.
Gerrit Hilgen
wiley +1 more source
Association of the connexin36 gene with juvenile myoclonic epilepsy [PDF]
Journal of Medical Genetics, 2004 Epilepsy is one of the most common and serious neurological disorders, with up to 60 million people affected worldwide.1 Juvenile myoclonic epilepsy (JME) is a common familial form that accounts for 5–10% of all epilepsy cases.2 This form belongs to the idiopathic epilepsy group, due to the absence of detectable structural or metabolic abnormalities ...
Mas, C +15 more
openaire +5 more sources
Connexin36 Forms Synapses Essential for Night Vision [PDF]
Neuron, 2002 Rod signals reach ganglion cells via at least five pathways. A new study in this issue of Neuron shows that all pathways from rods to ON-type ganglion cells require connexin36. This is the first physiological demonstration in mammals that a well-defined neural circuit requires a gap junction as an obligatory transmission step.
Demb, Jonathan B, Pugh, Edward N
openaire +2 more sources
Photoreceptor Coupling Mediated by Connexin36 in the Primate Retina [PDF]
The Journal of Neuroscience, 2012 Photoreceptors are coupled via gap junctions in many mammalian species. Cone-to-cone coupling is thought to improve sensitivity and signal-to-noise ratio, while rod-to-cone coupling provides an alternative rod pathway active under twilight or mesopic conditions (Smith et al., 1986; DeVries et al., 2002; Hornstein et al., 2005). Gap
Jennifer J, O'Brien +4 more
openaire +2 more sources
Is connexin36 critical for GABAergic hypersynchronization in the hippocampus? [PDF]
The Journal of Physiology, 2011 Non‐technical summary In some forms of incurable epilepsies, GABAergic interneurons, which physiologically mediate inhibition in the brain, are thought to mediate excitation. The presence of a specific form of electrical communication between these cells, which is mediated by structures called gap junctions, has been proposed to be involved in the ...
Michael, Beaumont, Gianmaria, Maccaferri
openaire +2 more sources
Glucose represses connexin36 in insulin-secreting cells [PDF]
Journal of Cell Science, 2005 The gap-junction protein connexin36 (Cx36) contributes to control the functions of insulin-producing cells. In this study, we investigated whether the expression of Cx36 is regulated by glucose in insulin-producing cells. Glucose caused a significant reduction of Cx36 in insulin-secreting cell lines and freshly isolated pancreatic rat islets.
ALLAGNAT F +4 more
openaire +5 more sources
Hierarchical retinal computations rely on hybrid chemical-electrical signaling
Cell Reports, 2023 Summary: Bipolar cells (BCs) are integral to the retinal circuits that extract diverse features from the visual environment. They bridge photoreceptors to ganglion cells, the source of retinal output.
Laura Hanson +3 more
doaj +1 more source
Connexin36 Mediates Spike Synchrony in Olfactory Bulb Glomeruli [PDF]
Neuron, 2005 Neuronal synchrony is important to network behavior in many brain regions. In the olfactory bulb, principal neurons (mitral cells) project apical dendrites to a common glomerulus where they receive a common input. Synchronized activity within a glomerulus depends on chemical transmission but mitral cells are also electrically coupled.
Christie, Jason M. +5 more
openaire +3 more sources
KCl -Permeabilized Pancreatic Islets: An Experimental Model to Explore the Messenger Role of ATP in the Mechanism of Insulin Secretion. [PDF]
PLoS ONE, 2015 Our previous work has demonstrated that islet depolarization with KCl opens connexin36 hemichannels in β-cells of mouse pancreatic islets allowing the exchange of small metabolites with the extracellular medium.
Javier Pizarro-Delgado +4 more
doaj +1 more source