Results 41 to 50 of about 1,550 (182)

Convergent NMDA receptor—Pannexin1 signaling pathways regulate the interaction of CaMKII with Connexin-36

Communications Biology, 2021
Siu et al use FRET imaging in neuronal cell lines to explore the interplay between the gap junction channel protein Connexin-36 (Cx36) and NMDA receptor and Pannexin 1-mediated calcium signaling. They demonstrate that an increase in intracellular calcium
Ryan C. F. Siu, Anna Kotova, Ksenia Timonina, Christiane Zoidl, Georg R. Zoidl   +4 more
doaj   +1 more source

PTEN Expression Regulates Gap Junction Connectivity in the Retina

Frontiers in Neuroanatomy, 2021
Manipulation of the phosphatase and tensin homolog (PTEN) pathway has been suggested as a therapeutic approach to treat or prevent vision loss due to retinal disease.
Ashley M. Chen, Shaghauyegh S. Azar, Alexander Harris, Nicholas C. Brecha, Nicholas C. Brecha, Nicholas C. Brecha, Nicholas C. Brecha, Luis Pérez de Sevilla Müller   +7 more
doaj   +1 more source

Dopamine-stimulated dephosphorylation of connexin 36 mediates AII amacrine cell uncoupling. [PDF]

, 2009
Gap junction proteins form the substrate for electrical coupling between neurons. These electrical synapses are widespread in the CNS and serve a variety of important functions.
Kothmann, W Wade, Massey, Stephen C, O\u27Brien, John   +2 more
core   +1 more source

AII amacrine cells discriminate between heterocellular and homocellular locations when assembling connexin36-containing gap junctions [PDF]

, 2014
Electrical synapses (gap junctions) rapidly transmit signals between neurons and are composed of connexins. In neurons, connexin36 (C×36) is the most abundant isoform; however, the mechanisms underlying formation of C×36-containing electrical synapses ...
Abd-El-Barr, Anderson, Bloomfield, Chai, Christie, Ciolofan, Deans, Dedek, Demb, Dong, Dunn, Feigenspan, Flores, Güldenagel, Han, Helbig, Hilgen, Hormuzdi, Kolb, Kothmann, Kranz, Kumar, Li, Li, Li, Li, Li, Lin, Lynn, Maxeiner, Mills, Münch, Pan, Plantard, Rash, Rice, Schubert, Shelley, Strettoi, Söhl, Vaney, Veruki, Wachtmeister, Weymouth, Yu   +44 more
core   +6 more sources

Identification of connexin36 in gap junctions between neurons in rodent locus coeruleus [PDF]

Neuroscience, 2007
Locus coeruleus neurons are strongly coupled during early postnatal development, and it has been proposed that these neurons are linked by extraordinarily abundant gap junctions consisting of connexin32 (Cx32) and connexin26 (Cx26), and that those same connexins abundantly link neurons to astrocytes.
J E, Rash, C O, Olson, K G V, Davidson, T, Yasumura, N, Kamasawa, J I, Nagy   +5 more
openaire   +2 more sources

Neural bases for the genesis and CO2 therapy of periodic Cheyne–Stokes breathing in neonatal male connexin-36 knockout mice

Frontiers in Neuroscience, 2023
Periodic Cheyne–Stokes breathing (CSB) oscillating between apnea and crescendo–decrescendo hyperpnea is the most common central apnea. Currently, there is no proven therapy for CSB, probably because the fundamental pathophysiological question of how the ...
Ana M. Casarrubios, Ana M. Casarrubios, Leonel F. Pérez-Atencio, Cristina Martín, José M. Ibarz, Eva Mañas, David L. Paul, Luis C. Barrio, Luis C. Barrio   +8 more
doaj   +1 more source

Downregulation of Neuronal and Dendritic Connexin36-Made Electrical Synapses Without Glutamatergic Axon Terminals in Spinal Anterior Horn Cells From the Early Stage of Amyotrophic Lateral Sclerosis

Frontiers in Neuroscience, 2018
Connexin36 (Cx36) forms gap junctions between neurons, which are called electrical synapses, enabling adjacent neurons to communicate directly. The participation of chemical synapses in neurodegeneration in amyotrophic lateral sclerosis (ALS) has long ...
Yuko Kobayakawa, Katsuhisa Masaki, Ryo Yamasaki, Wataru Shiraishi, Shotaro Hayashida, Shintaro Hayashi, Koichi Okamoto, Takuya Matsushita, Jun-ichi Kira   +8 more
doaj   +1 more source

Inadequate Triglyceride Management Worsens the Durability of Dipeptidyl Peptidase‐4 Inhibitor in Subjects with Type 2 Diabetes Mellitus

Journal of Diabetes Research, Volume 2017, Issue 1, 2017., 2017
Dipeptidyl peptidase‐4 (DPP‐4) inhibitors are often used all over the world and exert various beneficial effects including glucose‐lowering effect in many subjects with type 2 diabetes. It is poorly understood, however, which factors are closely related with the durability of glucose‐lowering effect by DPP‐4 inhibitor.
Masashi Shimoda, Maiko Miyoshi-Takai, Shintaro Irie, Akihito Tanabe, Atsushi Obata, Seizo Okauchi, Hidenori Hirukawa, Tomohiko Kimura, Kenji Kohara, Shinji Kamei, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto, Kazuya Yamagata   +13 more
wiley   +1 more source

The Current Status of Somatostatin‐Interneurons in Inhibitory Control of Brain Function and Plasticity

Neural Plasticity, Volume 2016, Issue 1, 2016., 2016
The mammalian neocortex contains many distinct inhibitory neuronal populations to balance excitatory neurotransmission. A correct excitation/inhibition equilibrium is crucial for normal brain development, functioning, and controlling lifelong cortical plasticity. Knowledge about how the inhibitory network contributes to brain plasticity however remains
Isabelle Scheyltjens, Lutgarde Arckens, Bruno Poucet   +2 more
wiley   +1 more source

Can Exposure to Environmental Chemicals Increase the Risk of Diabetes Type 1 Development?

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
Type 1 diabetes mellitus (T1DM) is an autoimmune disease, where destruction of beta‐cells causes insulin deficiency. The incidence of T1DM has increased in the last decades and cannot entirely be explained by genetic predisposition. Several environmental factors are suggested to promote T1DM, like early childhood enteroviral infections and nutritional ...
Johanna Bodin, Lars Christian Stene, Unni Cecilie Nygaard, Jill M. Norris   +3 more
wiley   +1 more source