Results 51 to 60 of about 1,550 (182)

Electrical synapses formed by connexin36 regulate inhibition- and experience-dependent plasticity [PDF]

Proceedings of the National Academy of Sciences, 2011
The mammalian brain constantly adapts to new experiences of the environment, and inhibitory circuits play a crucial role in this experience-dependent plasticity. A characteristic feature of inhibitory neurons is the establishment of electrical synapses, but the function of electrical coupling in plasticity is unclear.
Friso, Postma, Cheng-Hang, Liu, Caitlin, Dietsche, Mariam, Khan, Hey-Kyoung, Lee, David, Paul, Patrick O, Kanold   +6 more
openaire   +2 more sources

Connexin36 Gap Junction Blockade Is Ineffective at Reducing Seizure‐Like Event Activity in Neocortical Mouse Slices

Epilepsy Research and Treatment, Volume 2010, Issue 1, 2010., 2010
Despite much research, there remains controversy over the role of gap junctions in seizure processes. Many studies report anticonvulsant effects of gap junction blockade, but contradictory results have also been reported. The aim of this study was to clarify the role of connexin36 (Cx36) gap junctions in neocortical seizures.
Logan J. Voss, Noortje Mutsaerts, James W. Sleigh, Scott Baraban   +3 more
wiley   +1 more source

From Isles of Königsberg to Islets of Langerhans: Examining the Function of the Endocrine Pancreas Through Network Science

Frontiers in Endocrinology, 2022
Islets of Langerhans are multicellular microorgans located in the pancreas that play a central role in whole-body energy homeostasis. Through secretion of insulin and other hormones they regulate postprandial storage and interprandial usage of energy ...
Andraž Stožer, Marko Šterk, Marko Šterk, Eva Paradiž Leitgeb, Rene Markovič, Rene Markovič, Maša Skelin Klemen, Cara E. Ellis, Lidija Križančić Bombek, Jurij Dolenšek, Jurij Dolenšek, Patrick E. MacDonald, Marko Gosak, Marko Gosak   +13 more
doaj   +1 more source

Screening of gap junction antagonists on dye coupling in the rabbit retina. [PDF]

, 2007
Many cell types in the retina are coupled via gap junctions and so there is a pressing need for a potent and reversible gap junction antagonist. We screened a series of potential gap junction antagonists by evaluating their effects on dye coupling in the
Massey, Stephen C, Mills, Stephen L, Pan, Feng   +2 more
core   +1 more source

Animal Models of CNS Viral Disease: Examples from Borna Disease Virus Models

Interdisciplinary Perspectives on Infectious Diseases, Volume 2010, Issue 1, 2010., 2010
Borna disease (BD), caused by the neurotropic RNA virus, Borna Disease virus, is an affliction ranging from asymptomatic to fatal meningoencephalitis across naturally and experimentally infected warmblooded (mammalian and bird) species. More than 100 years after the first clinical descriptions of Borna disease in horses and studies beginning in the ...
Marylou V. Solbrig, Guey Chuen Perng
wiley   +1 more source

Functional Properties of Channels Formed by the Neuronal Gap Junction Protein Connexin36 [PDF]

The Journal of Neuroscience, 1999
The expression and functional properties of connexin36 (Cx36) were examined in two communication-deficient cell lines (N2A-neuroblastoma and PC-12 cells) transfected with Cx36 and in hippocampal neurons that express the connexin endogenously.
M. SRINIVAS, R. ROZENTAL, T. KOJIMA, R. DERMIETZEL, M. MEHLER, CONDORELLI, Daniele Filippo, J. A. KESSLER, D. C. SPRAY   +7 more
openaire   +3 more sources

Structural and functional consequences of Connexin 36 (Cx36) interaction with Calmodulin

Frontiers in Molecular Neuroscience, 2016
Functional plasticity of neuronal gap junctions involves the interaction of the neuronal connexin36 with calcium/calmodulin-dependent kinase II. The important relationship between Cx36 and CaMKII must also be considered in the context of another protein ...
Ryan CF Siu, Ekaterina Smirnova, Cherie Alicia Brown, Christiane Zoidl, David C Spray, Logan William Donaldson, Georg Zoidl   +6 more
doaj   +1 more source

Molecular determinants of magnesium-dependent synaptic plasticity at electrical synapses formed by connexin36 [PDF]

Nature Communications, 2014
Neuronal gap junction (GJ) channels composed of connexin36 (Cx36) play an important role in neuronal synchronization and network dynamics. Here we show that Cx36-containing electrical synapses between inhibitory neurons of the thalamic reticular nucleus are bidirectionally modulated by changes in intracellular free magnesium concentration ([Mg(2+)]i ...
Palacios-Prado, Nicolás, Chapuis, Sandrine, Panjkovich, Alejandro, Fregeac, Julien, Nagy, James I., Bukauskas, Feliksas F.   +5 more
openaire   +3 more sources

Strategic Positioning of Connexin36 Gap Junctions Across Human Retinal Ganglion Cell Dendritic Arbors

Frontiers in Cellular Neuroscience, 2018
Connexin36 (Cx36) subunits form gap junctions (GJ) between neurons throughout the central nervous system. Such GJs of the mammalian retina serve the transmission, averaging and correlation of signals prior to conveying visual information to the brain ...
Orsolya Kántor, Orsolya Kántor, Orsolya Kántor, Gergely Szarka, Gergely Szarka, Gergely Szarka, Gergely Szarka, Zsigmond Benkő, Zoltán Somogyvári, Emese Pálfi, Gábor Baksa, Gergely Rácz, Roland Nitschke, Roland Nitschke, Gábor Debertin, Gábor Debertin, Gábor Debertin, Gábor Debertin, Béla Völgyi, Béla Völgyi, Béla Völgyi, Béla Völgyi   +21 more
doaj   +1 more source

Intensity Coding in Two-Dimensional Excitable Neural Networks

, 2004
In the light of recent experimental findings that gap junctions are essential for low level intensity detection in the sensory periphery, the Greenberg-Hastings cellular automaton is employed to model the response of a two-dimensional sensory network to ...
Bair, Bardou, Bokil, Chialvo, Cleland, Copelli, Deans, Firestein, Greenberg, Hidaka, Kaplan, Kosaka, Lewis, Mauro Copelli, Osame Kinouchi, Purves, Rospars, Simões-de-Souza, Stevens, Tomé, Traub, Wiener, Zhang, Zorzenon dos Santos   +23 more
core   +2 more sources