Tubulin-Dependent Transport of Connexin-36 Potentiates the Size and Strength of Electrical Synapses
Cells, 2019 Connexin-36 (Cx36) electrical synapses strengthen transmission in a calcium/calmodulin (CaM)/calmodulin-dependent kinase II (CaMKII)-dependent manner similar to a mechanism whereby the N-methyl-D-aspartate (NMDA) receptor subunit NR2B facilitates ...
Cherie A. Brown +5 more
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Functional asymmetry and plasticity of electrical synapses interconnecting neurons through a 36-state model of gap junction channel gating. [PDF]
PLoS Computational Biology, 2017 We combined the Hodgkin-Huxley equations and a 36-state model of gap junction channel gating to simulate electrical signal transfer through electrical synapses.
Mindaugas Snipas +4 more
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Modulation of Connexin-36 Gap Junction Channels by Intracellular pH and Magnesium Ions
Frontiers in Physiology, 2018 Connexin-36 (Cx36) protein forms gap junction (GJ) channels in pancreatic beta cells and is also the main Cx isoform forming electrical synapses in the adult mammalian brain. Cx36 GJs can be regulated by intracellular pH (pHi) and cytosolic magnesium ion
Lina Rimkute +9 more
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Journal of Comparative Neurology, Volume 532, Issue 7, July 2024.Spinal neuronal pool innervating external urethral sphincter (EUS) in female mice has less motoneurons and interneurons compared to males. Spinal cord injury caused the reduction of EUS‐related neuronal pool in males but not in females. ABSTRACT Spinal cord injury (SCI) disrupts coordination between the bladder and the external urinary sphincter (EUS),
Sergei Karnup +5 more
wiley +1 more source
Connexin36 is a Negative Regulator of Differentiation in Human Neuroblastoma [PDF]
, 2013 Gap junctional intercellular communication (GJIC) and connexins (Cx) have been implicated in carcinogenesis and differentiation. GJIC is often perturbed and connexins are typically downregulated or aberrantly localized in cancer cells, including IMR-32 neuroblastoma cells [6, 7].
Mandeep Sidhu, Daniel J.
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Factors Influencing the Expression of Gap Junction Forming Connexin Proteins in the Retina of Vertebrate Animals [PDF]
, 2016 7
Kovács-Öller Tamás
core
Physiologic regulation of heart rate and blood pressure involves connexin 36-containing gap junctions [PDF]
, 2017 Chronically elevated sympathetic nervous activity underlies many cardiovascular diseases. Elucidating the mechanisms contributing to sympathetic nervous system output may reveal new avenues of treatment.
Ferrari A. U. +12 more
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Expression of Connexin36 in Cone Pedicles and OFF-Cone Bipolar Cells of the Mouse Retina [PDF]
The Journal of Neuroscience, 2004 Transgenic technology, immunocytochemistry, electrophysiology, intracellular injection techniques, and reverse transcription PCR were combined to study the expression of neuronal connexin36 (Cx36) in the outer plexiform layer of the mouse retina. Transgenic animals expressed either a fusion protein of full-length Cx36 with enhanced green fluorescent ...
Feigenspan, Andreas +8 more
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A new measure for the strength of electrical synapses
Frontiers in Cellular Neuroscience, 2015 Electrical synapses, like chemical synapses, mediate intraneuronal communication. Electrical synapses are typically quantified by subthreshold measurements of coupling, which fall short in describing their impact on spiking activity in coupled neighbors.
Julie S Haas
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Gap Junctions Link Regular-Spiking and Fast-Spiking Interneurons in Layer 5 Somatosensory Cortex [PDF]
, 2017 Gap junctions form electrical synapses that modulate neuronal activity by synchronizing action potential (AP) firing of cortical interneurons (INs). Gap junctions are thought to form predominantly within cortical INs of the same functional class and are ...
Hatch, Robert J. +4 more
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