Involvement of gap junction channels in the pathophysiology of migraine with aura
Frontiers in Physiology, 2014 Migraine is a common, recurrent and disabling primary headache disorder with a genetic component which affects up to 20 % of the population. One third of all patients with migraine experiences aura, a focal neurological disturbance that manifests itself ...
Denis eSarrouilhe +2 more
doaj +1 more source
Potential of activated microglia as a source of dysregulated extracellular microRNAs contributing to neurodegeneration in amyotrophic lateral sclerosis [PDF]
, 2020 Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron degeneration in adults, and several mechanisms underlying the disease pathology have been proposed.
Christoforidou, Eleni +2 more
core +1 more source
PLoS ONE, 2013 Connexin36 (Cx36), a trans-membrane protein that forms gap junctions between insulin-secreting beta-cells in the Langerhans islets, contributes to the proper control of insulin secretion and beta-cell survival.
Jacques-Antoine Haefliger +8 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2018 Electrical synapses are ubiquitous in interneuron networks. They form intercellular pathways, allowing electrical currents to leak between coupled interneurons.
Pepe Alcami +3 more
doaj +1 more source
Interactions between neural progenitor cells and microglia in the subventricular zone: physiological implications in the neurogenic niche and after implantation in the injured brain [PDF]
, 2018 The adult subventricular zone (SVZ) of the mammalian brain contains neural progenitor cells (NPCs) that continuously produce neuroblasts throughout life.
Pastor Loro, Ángel Manuel +2 more
core +1 more source
Iranian Biomedical Journal, 2017 Gap junctions (GJs) provide direct intercellular communications that are formed by hexameric protein subunits, called connexin (Cx). The role of Cxs in epileptogenesis has not received sufficient attention. Hippocampus with critical function in epileptogenesis has a wide network of GJs. We examined the protein expression levels of hippocampal Cx36 (the
Motaghi, Sahel +3 more
openaire +2 more sources
Cx36 Is a Target of Beta2/NeuroD1, Which Associates with Prenatal Differentiation of Insulin-producing β Cells [PDF]
, 2018 The insulin-producing β cells of pancreatic islets are coupled by connexin36 (Cx36) channels. To investigate what controls the expression of this connexin, we have investigated its pattern during mouse pancreas development, and the influence of three ...
Allagnat, Florent +7 more
core
Climbing Fiber Burst Size and Olivary Sub-threshold Oscillations in a Network Setting [PDF]
, 2012 The inferior olivary nucleus provides one of the two main inputs to the cerebellum: the so-called climbing fibers. Activation of climbing fibers is generally believed to be related to timing of motor commands and/or motor learning.
A Badura +41 more
core +6 more sources
Connexins and pannexins: from biology towards clinical targets. [PDF]
, 2016 Efficient cell communication is a prerequisite for the coordinated function of tissues and organs. In vertebrates, this communication is mediated by a variety of mechanisms, including the exchange of molecules between cells, and between cells and the ...
Haefliger, J.A., Meda, P.
core +1 more source
Trafficking of Connexin36 (Cx36) in the early secretory pathway
Abstract Gap junctions formed by the major neuronal connexin Cx36 function as electrical synapses in the nervous system and provide unique functions such as synchronizing activities or network oscillations. Although the physiological significance of electrical synapses for neuronal networks is well established, little is known about the
Stephan Tetenborg +6 more
openaire +2 more sources