Dendrodendritic electrical signaling via gap junctions is now an accepted feature of neuronal communication in the mammalian brain, whereas axodendritic and axosomatic gap junctions have rarely been described.
Farid eHamzei-Sichani +11 more
doaj +1 more source
Gap junctional communication in the adult CNS plays an important role in the synchronization of neuronal activities. In vitro studies have shown evidence of electrotonic coupling through gap junctions between sympathetic preganglionic motoneurons and between somatic motoneurons in the neonatal and adult rat spinal cord.
Marina, Nephtali +2 more
openaire +2 more sources
The intercellular synchronization of Ca2+ oscillations evaluates Cx36-dependent coupling.
Connexin36 (Cx36) plays an important role in insulin secretion by controlling the intercellular synchronization of Ca(2+) transients induced during stimulation.
Sabine Bavamian +6 more
doaj +1 more source
Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets [PDF]
This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.AIMS/HYPOTHESIS: Ageing can lead to reduced insulin sensitivity and loss of pancreatic beta cell function ...
Allagnat, F +7 more
core +3 more sources
Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin [PDF]
Epithelial tight junctions participate in the regulation of gene expression by controlling the activity of transcription factors that can interact with junctional components.
Balda, MS +6 more
core +1 more source
Encoding of Tactile Stimuli by Mechanoreceptors and Interneurons of the Medicinal Leech [PDF]
For many animals processing of tactile information is a crucial task in behavioral contexts like exploration, foraging, and stimulus avoidance. The leech, having infrequent access to food, developed an energy efficient reaction to tactile stimuli ...
Fathiazar, Elham +3 more
core +8 more sources
Intracellular Magnesium-Dependent Modulation of Gap Junction Channels Formed by Neuronal Connexin36 [PDF]
Gap junction (GJ) channels composed of Connexin36 (Cx36) are widely expressed in the mammalian CNS and form electrical synapses between neurons. Here we describe a novel modulatory mechanism of Cx36 GJ channels dependent on intracellular free magnesium ([Mg2+]i). We examined junctional conductance (gj) and its dependence on transjunctional voltage (Vj)
Palacios-Prado, Nicolas +10 more
openaire +3 more sources
Investigations of the functional role of connexin36 in sensory and sympathetic systems in adult mice
Electrical synapses formed by gap junctions composed of connexin36 (Cx36) occur between neurons in widespread areas of the mammalian central nervous system and enable neuron‐to‐neuron electrical coupling. We previously reported that dorsal root ganglia (DRG) sensory neurons containing transient receptor potential (TRP) channels ...
Katinka Stecina +8 more
openaire +1 more source
Convergence and segregation of the multiple rod pathways in mammalian retina. [PDF]
Using a multidisciplinary approach, we demonstrate that three different pathways are responsible for the transmission of rod signals across the mouse retina.
Bloomfield, S. A. +3 more
core +1 more source
Visual Transmission Deficits in Mice with Targeted Disruption of the Gap Junction Gene Connexin36 [PDF]
In the mammalian retina, rods feed into the cone pathway through electrotonic coupling, and recent histological data suggest the involvement of connexin36 (Cx36) in this pathway. We therefore generated Cx36 null mice and monitored the functional consequences of this deficiency on early visual transmission.
M, Güldenagel +7 more
openaire +2 more sources

