Results 31 to 40 of about 1,550 (182)

Connexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviors [PDF]

, 2010
Large-scale synchronous firing of neurons during seizures is modulated by electrotonic coupling between neurons via gap junctions. To explore roles for connexin36 (Cx36) gap junctions in seizures, we examined the seizure threshold of connexin36 knockout (
Cursons, Raymond T., Jacobson, Gregory M., Mason, Jonathan P., Melin, Sofia M., Sleigh, James W., Steyn-Ross, D. Alistair, Steyn-Ross, Moira L., Voss, Logan J.   +7 more
core   +2 more sources

GABAergic compensation in connexin36 knock-out mice evident during low-magnesium seizure-like event activity [PDF]

, 2010
Gap junctions within the cerebral cortex may facilitate cortical seizure formation by their ability to synchronize electrical activity. To investigate this, one option is to compare wild-type (WT) animals with those lacking the gene for connexin36 (Cx36 ...
Jacobson, Gregory M., Melin, Sofia M., Sleigh, James W., Voss, Logan J.   +3 more
core   +2 more sources

Inner retinal preservation in the photoinducible I307N rhodopsin mutant mouse, a model of autosomal dominant retinitis pigmentosa

Journal of Comparative Neurology, Volume 528, Issue 9, Page 1502-1522, June 15, 2020., 2020
Tvrm4 rhodopsin mutant mice undergo rapid photoreceptor loss upon bright light exposure. Early consequences on the inner retina involve mainly second‐order neurons and include quick dendritic retraction and axonal shrinkage in rod bipolar cells (RBCs) and, later, in cone BCs and the presence of anomalous globular synaptic ribbons (GR). Yet, BC survival
Antonia Stefanov, Elena Novelli, Enrica Strettoi   +2 more
wiley   +1 more source

Connexin36 localization to pinealocytes in the pineal gland of mouse and rat [PDF]

European Journal of Neuroscience, 2017
AbstractSeveral cell types in the pineal gland are known to establish intercellular gap junctions, but the connexin constituents of those junctions have not been fully characterized. Specifically, the expression of connexin36 (Cx36) protein andmRNAhas been examined in the pineal, but the identity of cells that produce Cx36 and that form Cx36‐containing
S. G. Wang, D. D. Tsao, K. G. Vanderpool, T. Yasumura, J. E. Rash, J. I. Nagy   +5 more
openaire   +2 more sources

Contrasting roles of axonal (pyramidal cell) and dendritic (interneuron) electrical coupling in the generation of neuronal network oscillations [PDF]

, 2003
Electrical coupling between pyramidal cell axons, and between interneuron dendrites, have both been described in the hippocampus. What are the functional roles of the two types of coupling?
Bibbig, A., Buhl, E.H., Hormuzdi, S.G., LeBeau, F.E.N., Monyer, H., Pais, I., Traub, R.D., Whittington, M.A.   +7 more
core   +2 more sources

Expression of Neuronal Connexin36 in AII Amacrine Cells of the Mammalian Retina [PDF]

The Journal of Neuroscience, 2001
We have studied the expression pattern of neuronal connexin36 (Cx36) in the mouse and rat retina. In vertical sections of both retinas, a polyclonal antibody directed against Cx36 produced punctate labeling in the inner plexiform layer (IPL). Intense immunoreactivity was localized to the entire OFF sublamina of the IPL, and much weaker staining could ...
A, Feigenspan, B, Teubner, K, Willecke, R, Weiler   +3 more
openaire   +2 more sources

Testing for a gap junction-mediated bystander effect in retinitis pigmentosa: secondary cone death is not altered by deletion of connexin36 from cones.

PLoS ONE, 2013
Retinitis pigmentosa (RP) relates to a group of hereditary neurodegenerative diseases of the retina. On the cellular level, RP results in the primary death of rod photoreceptors, caused by rod-specific mutations, followed by a secondary degeneration of ...
Katharina Kranz, François Paquet-Durand, Reto Weiler, Ulrike Janssen-Bienhold, Karin Dedek   +4 more
doaj   +1 more source

Highly restricted pattern of connexin36 expression in chick somite development [PDF]

Anatomy and Embryology, 2004
The gap junction protein connexin36 (CX36) has been well studied in the mature central nervous system, but there has been little information regarding its possible roles in embryonic development. We report here the isolation of the full-length chick CX36 coding sequence (predicted M(r) 35.1 kDa) and its strikingly restricted pattern of gene expression ...
Viviana M, Berthoud, Rashmi, Singh, Peter J, Minogue, Clifton W, Ragsdale, Eric C, Beyer   +4 more
openaire   +2 more sources

Function and Plasticity of Electrical Synapses in the Mammalian Brain: Role of Non-Junctional Mechanisms

Biology, 2022
Electrical transmission between neurons is largely mediated by gap junctions. These junctions allow the direct flow of electric current between neurons, and in mammals, they are mostly composed of the protein connexin36.
Sebastian Curti, Federico Davoine, Antonella Dapino   +2 more
doaj   +1 more source

Connexin 36 expression is required for electrical coupling between mouse rods and cones. [PDF]

, 2017
Rod-cone gap junctions mediate the so-called "secondary rod pathway", one of three routes that convey rod photoreceptor signals across the retina. Connexin 36 (Cx36) is expressed at these gap junctions, but an unidentified connexin protein also seems to ...
Asteriti, Sabrina, Cangiano, Lorenzo, Gargini, Claudia   +2 more
core   +1 more source