Results 121 to 130 of about 5,562,313 (185)

Gene therapy for hereditary deafness: Progress, challenges and translational implications from OTOF to GJB2

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Current Management & Limitations: Traditional auditory devices lack genetic curative potential and yield variable, non‐physiological hearing outcomes. OTOF gene therapy has shown promising clinical outcomes with dual‐AAV therapy. GJB2 gene therapy remains an emerging approach with significant translational challenges. Advances in vector design and cell‐
Jiahui Zhao, Mengzhao Xun, Yu Sun
wiley   +1 more source

Frozen in Place: Proximity Labeling Maps Glial Interactomes Across Cell States

Glia, Volume 74, Issue 10, October 2026.
Proximity labeling enables cell‐type‐specific and spatially resolved mapping of glial protein networks. Proximity labeling approaches provide insights into glial function under physiological and pathological conditions. ABSTRACT Glial cells, including radial glia, oligodendrocyte precursor cells (OPCs), oligodendrocytes, astrocytes, and microglia, are ...
João Baltar, Rebecca Abati, Luísa Florido, Matthew G. Holt   +3 more
wiley   +1 more source

Evaluation of electrocardiographic parameters in patients with hearing loss genotyped for the connexin 26 gene (GJB2) mutations

Brazilian Journal of Otorhinolaryngology
Introduction: Several studies have associated congenital sensorineural hearing loss in children with prolongation of the cardiac parameter QTc. The cause of this association is unknown.
Agnieszka Sanecka, Elzbieta Katarzyna Biernacka, Magdalena Sosna, Malgorzata Mueller-Malesinska, Rafal Ploski, Henryk Skarzynski, Ryszard Piotrowicz   +6 more
doaj   +1 more source

Effect of Zinc Oxide Nanoparticles From Infant Formula Milk Powder on Colon Cells In Vitro

Journal of Applied Toxicology, Volume 46, Issue 10, Page 3437-3445, October 2026.
ABSTRACT Zinc is an essential trace element that participates in numerous metabolic processes; however, excessive exposure may interfere with the absorption of other metals, such as copper. In recent years, nanotechnology has experienced rapid growth, and zinc oxide nanoparticles (ZnO NPs) have garnered significant attention due to their versatile ...
Gloria Salinas‐Lucero, Karla Juarez‐Moreno, Rafael Vazquez‐Duhalt   +2 more
wiley   +1 more source

Do Stimulants Promote Arrhythmic Risk: Insights From a Human‐Induced Pluripotent Stem Cell‐Derived Cardiomyocyte Model

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
At clinically relevant plasma concentrations, stimulant medications produced minimal effects on conduction velocity but modulated automaticity and repolarization in a hiPSC‐derived cardiomyocyte (hiPSC‐CM) model. These findings provide a foundation for future investigations of stimulant‐associated cardiac safety and support the utility of hiPSC‐CM ...
Alia Arslanova, Samantha Wong, Sonia Franciosi, Glen F. Tibbits, Maksymilian Prondzynski, Shubhayan Sanatani   +5 more
wiley   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

A Novel Striated Membrane Contact Site in Vestibular Hair Cells

Biology of the Cell, Volume 118, Issue 10, October 2026.
The mammalian vestibular system features type I and II hair cells (HCs) with distinct neurotransmission: type I uses both ribbon synapses and rapid non‐quantal transmission (NQT). We reveal a novel striated membrane contact between type I HCs and calyceal afferents, linked to atypical mitochondria.
Nicolas Brouilly, Nathalie Pujol, Fabrice Richard, Chantal Cazevieille, Jennifer Stone, Ruth Anne Eatock, Rémy Pujol   +6 more
wiley   +1 more source

Cerebellar astrocytic alterations in depression

Translational Psychiatry
Accumulating evidence suggests dysfunction of cerebellar-cerebral circuits in depression. However, the potential cellular and molecular alterations associated with depression in the cerebellum remain largely uncharacterized.
Christa Hercher, Gina Abajian, Maria Antonietta Davoli, Gustavo Turecki, Naguib Mechawar   +4 more
doaj   +1 more source

Experimental Study on Connexin43 Expression in "Zusnali"(ST 43) with Fluorescence Dual-label Technique in Rats

针刺研究, 2005
Objective: To probe into the expression of connexin(Cx)43 in rat's "Zusanli"(ST 36) and its possible relationship with acupoint and meridian Methods: Twenty SD rats were evenly randomized into control(non-acupoint) group and electroacupuncture(EA) group ...
ZHENG Cui-hong, HUANG Guang-ying, ZHANG Ming-min   +2 more
doaj   +2 more sources

Permeant-specific gating of connexin 30 hemichannels. [PDF]

J Biol Chem, 2017
Nielsen BS, Alstrom JS, Nicholson BJ, Nielsen MS, MacAulay N.   +4 more
europepmc   +1 more source