Results 101 to 110 of about 1,281 (179)

Biodiversity, traditional medicine and public health: where do they meet? [PDF]

, 2007
Given the increased use of traditional medicines, possibilities that would ensure its successful integration into a public health framework should be explored.
Rômulo RN Alves, Ierecê ML Rosa, WHO World Health Organization, C Good, WM Gesler, Millennium Ecosystem Assessment, C Anyinam, RRN Alves, AJ McMichael, J Lebel, P Pushpangadan, E Chivian, CJ Cowden, KC Nicolaou, WP McGuire, BM Olivera, AB Malmberg, K Valentino, GP Miljanich, SS Bowersox, GP Jones, PK Anderson, PR Epstein, P Daszak, RS Ostfeld, JF Walsh, RS Ostfeld, SS Morse, RP Wenzel, AJ McMichael, P Reiter, D Bell, P Shanley, GC Daily, JB Calixto, J Kerharo, CA Anyinam, L Castello, S Gillingham, B Child, RS Pomeroy, K Michael, E Lev, E Yesilada, RRN Alves, MO Adeola, NR Farnsworth, NR Farnsworth, DD Soejarto, F Grifo, F Grifo, E Chivian, Center for Biodiversity and Conservation (CBC), E Chivian, NR Farnsworth, NR Farnsworth, MJ Balick, PA Cox, NR Farnsworth, PA Cox, WE Kunin, JGW Marques, World Resources Institute, NG Bisset, BK Carté, DJ Faulkner, S Kang, CM Correa, R Lettington, K Ten Kate, A Hamilton, GT Prance, W Balée, W Balée, LC Branch, MCM Amorozo, RA Voeks, JR Stepp, C Fowler, W Beinart, RA Voeks, OA Sodeinde, SR Silva, SBB – Sociedade brasileira de Botânica, SR Silva, PAGM De Smet, DS Fabricant, E Ernst, WHO (World Health Organization), J Still, PR Schnurrenberger, V Brown, SKH Lee, RP Labadie, G Bodeker, J Giordano   +95 more
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Influence of Disulfide Connectivity on Structure and Bioactivity of α-Conotoxin TxIA

Molecules, 2014
Cone snails express a sophisticated arsenal of small bioactive peptides known as conopeptides or conotoxins (CTxs). Through evolutionary selection, these peptides have gained the ability to interact with a range of ion channels and receptors, such as ...
Yong Wu, Xiaosa Wu, Jinpeng Yu, Xiaopeng Zhu, Dongting Zhangsun, Sulan Luo   +5 more
doaj   +1 more source

Venomics as a Drug Discovery Platform: Identifying Conopeptides with Pharmacological Activity [PDF]

, 2020
Cone snail venom is a mixture of disulfide-constrained peptides (conotoxins), hormone-like peptides, and proteins that have been ‘weaponized’ for predation and defense.
Grandal, Meghan Kathleen
core   +1 more source

A novel α-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity. [PDF]

, 2018
We here describe a novel α-conopeptide, Eu1.6 from Conus eburneus, which exhibits strong anti-nociceptive activity by an unexpected mechanism of action.
Adams, David, Bartels, Peter, Dai, Qing, Dai, Qiuyun, Dong, Mingxin, Du, Tianpeng, Guo, Jiabin, Jiang, Ling, Liu, Zhuguo, Peng, Shuangqing, Sadeghi, Mahsa, Sun, Ting, Wang, Shuo, Yu, Shuo, Zhu, Cui   +14 more
core   +3 more sources

Novel γ-carboxyglutamic acid-containing peptides from the venom of Conus textile [PDF]

, 2006
Author Posting. © The Author(s), 2006. This is the author's version of the work. It is posted here by permission of Blackwell for personal use, not for redistribution.
Czerwiec, Eva, Furie, Barbara C., Furie, Bruce, Hambe, Bjorn, Kalume, Dario E., Roepstorff, Peter, Stenflo, Johan   +6 more
core   +1 more source

Recruitment of Glycosyl Hydrolase Proteins in a Cone Snail Venomous Arsenal: Further Insights into Biomolecular Features of Conus Venoms

Marine Drugs, 2012
Cone snail venoms are considered an untapped reservoir of extremely diverse peptides, named conopeptides, displaying a wide array of pharmacological activities.
Philippe Favreau, Igor Križaj, Frédéric Ducancel, Reto Stöcklin, Florian Noguier, Sébastien Dutertre, Daniel Biass, David Piquemal, Yves Terrat, Adrijana Leonardi, Aude Violette   +10 more
doaj   +1 more source

P-superfamily conopeptides [PDF]

, 2006
ReportThe present invention is directed to P-superfamily conopeptides, to DNA encoding precursors of the P-superfamily conopeptides and to the precursor ...
Hooper, David, Olivera, Baldomero M.
core  

Analgesic effect of highly reversible ω-conotoxin FVIA on N type Ca²⁺ channels

Molecular Pain, 2010
Background N-type Ca2+ channels (Cav2.2) play an important role in the transmission of pain signals to the central nervous system. ω-Conotoxin (CTx)-MVIIA, also called ziconotide (Prialt®), effectively alleviates pain, without causing addiction, by ...
Kim Hyun Jeong, Na Heung Sik, Suh Hong-Won, Ryu Jae Ha, Jung Hyun Ho, Lee Ju Yeon, Choi Hee-Woo, Back Seung Keun, Kim Yoonji, Lee Seungkyu, Rhim Hyewhon, Kim Jae Il   +11 more
doaj   +1 more source

Conus peptides: phylogenetic range of biological activity [PDF]

, 1992
Journal ArticleThe major function of the venoms of the predatory marine snails belonging to the genus Conus is to paralyze prey. Thus, the venom of each Conus species acts on receptors and ion channels of the prey; previous studies suggested much less ...
Cruz, Lourdes J., Olivera, Baldomero M.
core  

Cone Snail Broad-Transcriptomics Elucidate the Evolutionary Diversification and Anti-Microbial Potential of Conopeptides

Journal of Marine Science and Engineering
Conus venoms are both highly powerful and complex, exhibiting a remarkably intriguing molecular variability. The biologic reasons behind such astonishing molecular diversity are yet to be fully understood.
José Morim, Yihe Zhao, Lei Huang, Agostinho Antunes   +3 more
doaj   +1 more source