Results 21 to 30 of about 18,612 (160)
Biology, 2022 Predatory cone snails (Conus) developed a sophisticated neuropharmacological mechanism to capture prey, escape against other predators, and deter competitors.
Akira Kio V. Kikuchi, Lemmuel L. Tayo
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Chemical Synthesis and NMR Solution Structure of Conotoxin GXIA from Conus geographus
Marine Drugs, 2021 Conotoxins are disulfide-rich peptides found in the venom of cone snails. Due to their exquisite potency and high selectivity for a wide range of voltage and ligand gated ion channels they are attractive drug leads in neuropharmacology.
David A. Armstrong +5 more
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Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. [PDF]
PLoS Computational Biology, 2011 α-Conotoxins potently inhibit isoforms of nicotinic acetylcholine receptors (nAChRs), which are essential for neuronal and neuromuscular transmission.
Rilei Yu, David J Craik, Quentin Kaas
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ω-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Cav2.2 Ion Channels
Marine Drugs, 2012 The neuronal voltage-gated N-type calcium channel (Cav2.2) is a validated target for the treatment of neuropathic pain. A small library of anthranilamide-derived ω-Conotoxin GVIA mimetics bearing the diphenylmethylpiperazine moiety were prepared and ...
Peter J. Duggan +7 more
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Marine Drugs, 2013 Conotoxins are small peptides present in the venom of cone snails. The snail uses this venom to paralyze and capture prey. The constituent conopeptides display a high level of chemical diversity and are of particular interest for scientists as tools employed in neurological studies and for drug development, because they target with exquisite ...
Gerwig, G.J. +4 more
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Conotoxin protein classification using free scores of words and support vector machines
BMC Bioinformatics, 2011 Background Conotoxin has been proven to be effective in drug design and could be used to treat various disorders such as schizophrenia, neuromuscular disorders and chronic pain.
Nuel Gregory +3 more
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Marine Drugs, 2023 Chronic pain is one of the most prevalent health problems worldwide. An alternative to suppress or alleviate chronic pain is the use of peptide drugs that block N-type Ca2+ channels (Cav2.2), such as ω-conotoxin MVIIA.
Xiufang Ding +9 more
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Synthesis and Biological Activity of Novel α-Conotoxins Derived from Endemic Polynesian Cone Snails
Marine Drugs, 2023 α-Conotoxins are well-known probes for the characterization of the various subtypes of nicotinic acetylcholine receptors (nAChRs). Identifying new α-conotoxins with different pharmacological profiles can provide further insights into the physiological or
Yazid Mohamed Souf +8 more
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The T-superfamily of Conotoxins [PDF]
Journal of Biological Chemistry, 1999 Nous rapportons la découverte et la caractérisation initiale de la super-famille T des conotoxines. Huit peptides différents de la superfamille T de cinq espèces de Conus ont été identifiés ; ils partagent une séquence de signal consensuelle et un arrangement conservé de résidus de cystéine (- -CC- -CC-).
Colin Walker +12 more
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Journal of Genetic Engineering and BiotechnologyBackground: Venomous marine cone snails produce unique neurotoxins called conopeptides or conotoxins, which are valuable for research and drug discovery.
Mousa O. Germoush +9 more
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